Understanding how high blood sugar affects brain function and behavior
An investigation of hyperglycemia-induced region-specific changes in brain metabolism and behavior
['FUNDING_R15'] · BAYLOR UNIVERSITY · NIH-11042379
This study is looking at how high blood sugar affects the brain and behavior in people with depression, especially those with diabetes, to help create better, personalized treatments for them.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR UNIVERSITY (nih funded) |
| Locations | 1 site (WACO, UNITED STATES) |
| Trial ID | NIH-11042379 on ClinicalTrials.gov |
What this research studies
This research investigates how hyperglycemia, or high blood sugar, leads to specific changes in brain metabolism and behavior. By focusing on different regions of the brain, the study aims to uncover the relationship between metabolic dysfunction and behavioral symptoms in individuals with depression, particularly those with chronic conditions like diabetes. The research will utilize advanced techniques to analyze brain tissue at multiple levels, including mitochondrial structure and gene expression, to better understand these changes. The goal is to personalize treatment approaches for patients suffering from depression linked to metabolic issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with depression who also have chronic conditions such as diabetes or cardiovascular disease.
Not a fit: Patients without depression or those not experiencing chronic metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for patients with depression, particularly those who are treatment-resistant.
How similar studies have performed: While there have been descriptive studies on immuno-metabolic depression, this research aims to provide empirical evidence and is exploring a relatively novel approach.
Where this research is happening
WACO, UNITED STATES
- BAYLOR UNIVERSITY — WACO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VICHAYA, ELISABETH GOOD — BAYLOR UNIVERSITY
- Study coordinator: VICHAYA, ELISABETH GOOD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.