Condition

Hyperlipidemia clinical trials and research

• 25Clinical trials
• 7NIH research projects
• 13Countries

Newest Hyperlipidemia clinical trials

All recruiting trials (25)

• Enlicitide (MK-0616) for adults with high cholesterol in India

  This study tests whether enlicitide helps lower bad cholesterol (LDL-C) compared with placebo in adults with hyperlipidemia/hypercholesterolemia.

  Recruiting at 2 sites Phase 3 Merck Sharp & Dohme LLC · Belagavi, Karnataka and 1 other locations · NCT07821944

• HRS-7249 extension study for people with high triglycerides

  This extension study tests whether repeat injections of HRS-7249 are safe and keep triglyceride levels low in adults who previously completed the parent study or have high fasting triglycerides.

  Recruiting at 2 sites Phase 2 Fujian Shengdi Pharmaceutical Co., Ltd. · Jinan, Shandong and 1 other locations · NCT07799688

• Bacillus subtilis and Enterococcus faecium Probiotic Plus Lipid-Lowering Therapy for HTG-AP

  This trial tests whether adding a probiotic capsule to standard lipid-lowering therapy helps people with mild HTG-AP see lower triglycerides and better recovery.

  Recruiting Phase 4 Zhongshan Hospital Xiamen University · Xiamen, Fujian · NCT07720232

• EHR-guided LDL cholesterol optimization after a heart event

  A pharmacist-guided program using electronic health records to help adults in Alberta reach LDL goals after a heart event by adjusting medications and ordering tests.

  Recruiting at 2 sites University of Alberta · Edmonton, Alberta and 1 other locations · NCT07685639

• Spermidine supplement for lipid and weight changes in adults with obesity and high cholesterol

  This study tests whether taking spermidine daily for 1 month can improve blood lipids and body weight in adults who are overweight or obese with high cholesterol, while monitoring safety.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT07662330

• Digital health platform to help prevent and manage high blood pressure, lipids, and kidney and heart disease

  This trial tests a mobile digital health platform to help people with hypertension, dyslipidemia, and related conditions in New Taipei City see if the platform improves blood pressure, cholesterol, and kidney health.

  Recruiting New Taipei City Medical Association · New Taipei City · NCT07588256

• Community-based exercise and lifestyle program for people at risk of metabolic syndrome

  A community program tests whether a structured exercise and lifestyle plan can improve heart and blood health in people with hypertension, high cholesterol, or high blood sugar.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT07578090

• Exercise-prescription mini-program for people with high blood pressure, high blood sugar, high cholesterol, or high uric acid.

  This study will try a digital exercise-prescription mini-program to help adults with one or more of the 'Four Highs' increase physical activity and improve related health measures over six months in primary care.

  Recruiting China National Center for Cardiovascular Diseases · Beijing · NCT07400549

• Using an algorithm and team-based care to improve cholesterol in people with atherosclerotic cardiovascular disease

  This project will see if using an algorithm plus a physician-and-pharmacist team to guide lipid treatment lowers LDL cholesterol in people with atherosclerotic cardiovascular disease compared with usual care.

  Recruiting Colorado Prevention Center · Aurora, Colorado · NCT07334834

• Rapid escalation of cholesterol-lowering treatment to prevent repeat heart events

  This project will try frequent LDL-C checks and quicker increases in lipid-lowering medicines for adults with recent or chronic coronary artery disease to help them reach LDL goals and reduce repeat heart problems.

  Recruiting Chinese University of Hong Kong · Shatin, New Terrritories · NCT07311941

• SHR-1918 to lower LDL cholesterol and triglycerides in adults with hyperlipidemia

  This trial tests whether SHR-1918 can further lower LDL cholesterol and triglycerides in adults with hyperlipidemia who are already on a stable statin dose.

  Recruiting Phase 3 Beijing Suncadia Pharmaceuticals Co., Ltd · Hangzhou, Zhejiang · NCT07230730

• HRS-1301 for lowering high cholesterol (dyslipidemia)

  This will test whether HRS-1301 can lower LDL cholesterol over 12 weeks in adults with high cholesterol or increased risk of heart disease.

  Recruiting Phase 2 Shandong Suncadia Medicine Co., Ltd. · Harbin, Heilongjiang · NCT07229937

• COR-1004 for adults with high LDL cholesterol

  This trial will test a single injectable dose of COR-1004 to see if it's safe and how it changes LDL cholesterol in otherwise healthy adults with LDL ≥100 mg/dL who are not taking cholesterol medicines.

  Recruiting at 2 sites Phase 1 Corsera Health · Christchurch and 1 other locations · NCT07229118

• ARO-DIMERPA for adults with mixed high cholesterol and triglycerides

  This trial tests whether ARO-DIMERPA, given as a single dose or repeated doses, can lower LDL cholesterol and triglycerides in adults with mixed hyperlipidemia.

  Recruiting at 19 sites Phase 1/2 Arrowhead Pharmaceuticals · Charlestown, New South Wales and 18 other locations · NCT07223658

• Managing multiple medications in older adults with chronic diseases

  This project will see if taking many different medicines changes the health outlook of people aged 65 and older who have chronic conditions.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07180368

• Inspire HER: a heart-health and stress-support program for Black women

  This project will test whether the Inspire HER lifestyle program helps Black women with higher heart disease risk improve heart health and manage stress.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06966258

• Preventive screening and health coaching for people facing food insecurity

  A health coaching program delivered virtually is being tested to see if it lowers heart-disease risk and improves blood pressure, cholesterol, and diabetes markers in low-income adults who have limited access to food and healthcare.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT06907524

• Examining the link between gut bacteria, isoflavones, and cholesterol levels

  This study is testing how certain plant compounds in food might change gut bacteria and cholesterol levels in people with high cholesterol and healthy individuals to see if it can help improve heart health.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06890780

• Digital health coaching using wearable technology for chronic disease prevention

  This study is testing whether digital health coaching with wearable technology can help people at risk of chronic diseases like high blood pressure and diabetes make healthier lifestyle choices to prevent these conditions.

  Recruiting Alexandra Hospital · Singapore · NCT06752772

• Understanding self-care abilities of farmers and fishermen with chronic diseases

  This study is trying to see how farmers and fishermen with heart and diabetes issues can better take care of themselves and improve their health through tailored education and tools.

  Recruiting Chang Gung Memorial Hospital · Mailiao, Yun Lin Hsien · NCT06703151

• Investigating body fat distribution and its impact on metabolic diseases in Japanese adults

  This study looks at how the way body fat is distributed affects the risk of metabolic and heart diseases in Japanese adults.

  Recruiting Osaka Metropolitan University · Sakai, Osaka · NCT06694012

• Ursodeoxycholic acid helps prevent glucose intolerance in statin users

  This study is testing if taking Ursodeoxycholic acid along with a common cholesterol medication can help people with high cholesterol avoid problems with blood sugar levels.

  Recruiting at 2 sites First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi and 1 other locations · NCT06684106

• AI 'Smart Family Doctor' support for people after CABG or PCI

  We will test whether an AI-assisted smartphone 'Smart Family Doctor' program helps adults after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) better control blood pressure, blood sugar, and cholesterol.

  Recruiting China National Center for Cardiovascular Diseases · Ürümqi, Xinjiang · NCT06615609

• Short-term high-dose rosuvastatin effects on coronary plaque using photon-counting CT

  This trial tests whether a short course of intensified rosuvastatin (40 mg) changes coronary plaque composition and flow on photon‑counting coronary CT in statin‑naive adults with stable chest pain and mild atherosclerosis.

  Recruiting Semmelweis University · Budapest, Budapest · NCT06603363

• Evaluating HST101 for lowering cholesterol in Chinese patients

  This study is testing if a new drug called HST101 can lower cholesterol levels in Chinese patients who have high cholesterol and are at risk for heart disease.

  Recruiting at 17 sites Phase 3 Hasten Biopharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 17 other locations · NCT06568471

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Fibroblast Growth Factor 1 to Reduce High Lipids and Plaque in Adults with Diabetes

  A new approach uses a modified FGF1 protein to lower bad cholesterol and prevent artery plaque buildup in adults with Type 2 diabetes, aiming for safer and more effective treatment.

  NIH research University of Arizona · Tucson, United States · NIH-11535001

• PFAS exposure pathways and their link to high cholesterol in rural farmers

  This grant studies how certain durable chemicals in the environment affect cholesterol and health in rural communities that farm with waste-derived materials.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11425389

• Modified FGF1 protein to lower blood fats and protect arteries

  This project develops a modified natural protein (FGF1) to lower blood fats and help people with diabetes or metabolic syndrome avoid artery-clogging plaque.

  NIH research University of Louisville · Louisville, United States · NIH-11235157

• Improving cholesterol management for patients in the emergency department

  This study is looking at a new way to help people with high cholesterol who come to the emergency room for chest pain, by giving them special treatment during their visit to see if it helps lower their cholesterol better than the usual care.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11056835

• Fibroblast growth factor 1 helps prevent high cholesterol and artery disease

  This study is looking at a special version of a protein called FGF1 to see if it can help lower cholesterol and prevent plaque buildup in arteries, which could lead to a safer treatment option for people dealing with heart issues, diabetes, or fatty liver disease.

  NIH research University of Louisville · Louisville, United States · NIH-10984962

• IL-19's role in improving lymphatic function during high cholesterol levels

  This study is looking at how a protein called IL-19 influences the lymphatic system and inflammation related to heart disease, with the hope that improving lymphatic function could help reduce harmful plaque in arteries, which might lead to new treatments for better heart health.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-10825817

• How diet affects liver cell changes and cholesterol levels

  This study is looking at how what we eat affects liver cells as we get older, especially for people who struggle with lowering their cholesterol even with medications, and it hopes to find ways to help them manage their cholesterol better through diet changes.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10674261

Related topics

Quick answers

How many Hyperlipidemia clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (11 trials), United States (3 trials), Taiwan (3 trials), Canada (2 trials), New Zealand (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 2, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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