Understanding how high blood sugar affects the aorta and its recovery
Official title: Mechanistic Analysis of Aortic Growth and Remodeling due to Hyperglycemia and Recovery
Funded at University of Minnesota · NIH-10900173 · Data updated 2026-11-12
This study is looking at how long-term high blood sugar affects a key artery in the body and whether getting blood sugar back to normal can help fix any damage, which could lead to better heart health for people with diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 1F31HL173986-01 |
| Project ID | NIH-10900173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who experience issues related to high blood sugar and cardiovascular health.
✕Less likely to help
Patients without diabetes or those who do not have cardiovascular complications may not benefit from this research.
What this research studies
This research investigates the impact of chronic high blood sugar on the aorta, a major artery in the body, and how it undergoes changes that can lead to cardiovascular issues. By using a diabetic mouse model, the study aims to explore the mechanical and biological alterations in the aorta caused by hyperglycemia. Additionally, it will assess whether restoring normal blood sugar levels can reverse these harmful changes. The findings could provide insights into potential interventions for improving arterial health in diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cardiovascular complications in patients with diabetes.
How similar studies have gone: Previous research has shown that interventions to restore glycemic control can lead to improvements in arterial stiffness, suggesting a potential for success in this area.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Flanary, Shannon M — University of Minnesota
- Study coordinator: Flanary, Shannon M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.