Investigating how maternal health during pregnancy affects the heart health of their children.
Official title: Hyperglycemia and Adverse Pregnancy Outcome Study-Cardiovascular Health of HAPO Offspring (HAPO CVH)
Funded at Lurie Children's Hospital of Chicago · NIH-11047566 · Data updated 2026-11-12
This study is looking at how a mother's high blood sugar during pregnancy might affect her child's heart health as they grow up, and it's for young adults who want to understand their own health better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,686,303 |
| NIH project number | 5R01HL160921-03 |
| Project ID | NIH-11047566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young adults aged 18-25 who were born to mothers with gestational diabetes or other related conditions.
✕Less likely to help
Patients who are older than 25 or those who do not have a history of maternal gestational health issues may not benefit from this research.
What this research studies
This research focuses on understanding how maternal conditions, such as high blood sugar during pregnancy, impact the cardiovascular health of their children as they grow into young adults. By studying a large group of offspring from a previous study, researchers will assess various health indicators like blood pressure, body fat, and blood sugar levels. The goal is to identify the connections between maternal health factors and the cardiovascular risks faced by their children, potentially leading to better prevention strategies. Participants will undergo comprehensive health assessments to gather data on their cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in children whose mothers experienced gestational health issues.
How similar studies have gone: Previous studies have shown promising results in understanding the links between maternal health and offspring cardiovascular outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Brickman, Wendy J — Lurie Children's Hospital of Chicago
- Study coordinator: Brickman, Wendy J
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular health in the offspring of pregnancies affected by gestational glucose and weight
This study follows young adults whose mothers had gestational diabetes or related conditions to understand how pregnancy health affects their heart and blood vessel health over time.
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Intergenerational heart health: studying how a mother's gestational health affects offspring cardiovascular risk
This grant studies how a mother’s health during pregnancy may influence her child’s heart health in young adulthood.
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Glycemic and metabolic profiling during pregnancy to predict future heart disease risk
A pregnancy-focused study uses blood tests and metabolic data to predict a mom’s risk of cardiovascular disease years after delivery.
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Maternal heart health starts at home: Targeting social needs to improve pregnancy and postpartum heart health
Aimed at improving heart health for pregnant and postpartum people by addressing social needs like housing and access to care.
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Pregnancy, lupus, and heart health in women with lupus
This study looks at how managing lupus during pregnancy can affect blood pressure and heart health for women with the disease.
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Impact of pregnancy microbiomes on mom and baby heart health in a diverse group
Aimed at understanding how the microbiomes in the mother’s body relate to heart health risks for both mother and child during and after pregnancy, with a focus on diverse populations.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.