Condition

Diarrhea clinical trials and research

• 19Clinical trials
• 25NIH research projects
• 1New in 30 days
• 16Countries

Newest Diarrhea clinical trials

All recruiting trials (19)

• Gut health follow-along with Peachbiotic in adults

  This single-arm study tests whether Peachbiotic taken daily for 12 weeks helps adults with gut symptoms feel better.

  Recruiting Peach Perfect · Las Vegas, Nevada · NCT07927907

• Impact of a climate-resilient WASH package in Karamoja schools

  This study tests a climate-resilient water, sanitation and hygiene package in severely water-insecure primary schools in Karamoja to see if it reduces diarrhea and respiratory infections and improves attendance, especially among girls.

  Recruiting Unicef · Moroto · NCT07823231

• Do home water filters improve health for people with private wells in rural Central Appalachia

  This study tests whether providing point-of-use water filters to households using well or spring water in rural Central Appalachia can reduce acute gastrointestinal illness.

  Recruiting Virginia Polytechnic Institute and State University · Johnson City, Tennessee and 1 other locations · NCT07818902

• Balanced IV Fluids for Kids with Acute Gastroenteritis

  This study compares balanced crystalloids versus normal saline for IV hydration in young children with acute gastroenteritis to see if it improves acid–base status and clinical outcomes.

  Recruiting Aydin Adnan Menderes University · Aydin · NCT07610382

• Brenipatide (LY3537031) treatment for adults with IBS‑D

  This will test whether brenipatide (LY3537031) given under the skin helps adults with IBS‑D reduce belly pain and improve stool consistency compared with placebo.

  Recruiting at 80 sites Phase 2 Eli Lilly and Company · Mesa, Arizona and 88 other locations · NCT07545759

• Understanding ileorectal syndrome after total colectomy

  This project will follow adults who had a total colectomy with ileorectal anastomosis to see how common and how severe ileorectal syndrome is and how it affects quality of life.

  Recruiting Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · Diyarbakır · NCT07385196

• Rifaximin plus oral rehydration for children 6–11 with acute diarrhea

  This test looks at whether adding rifaximin 200 mg (three times daily for 3 days) to oral rehydration helps children 6–11 with likely bacterial acute diarrhea recover faster and checks how the drug is processed and tolerated.

  Recruiting at 10 sites Phase 4 Bausch Health Americas, Inc. · Lynwood, California and 9 other locations · NCT07285785

• Gut bacteria and diarrhea in breast cancer patients on pyrotinib

  This study will see if gut bacteria differ between breast cancer patients on pyrotinib who develop diarrhea and those who don’t, to understand why this side effect happens.

  Recruiting Hubei Cancer Hospital · Wuhan, Hubei · NCT07264985

• First-in-human dose escalation of the Shigella-04 vaccine in healthy young adults

  This test checks whether two intramuscular doses of the Shigella-04 vaccine are safe and produce an immune response in healthy adults ages 18 to 49.

  Recruiting Phase 1 Inventprise Inc. · Cincinnati, Ohio · NCT07205926

• Using SER-155 to treat diarrhea in patients receiving immunotherapy

  This study is testing if a new medication called SER-155 can help adults with severe diarrhea caused by immunotherapy feel better with fewer side effects.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06801067

• Combining a low-FODMAP diet with mirtazapine to treat IBS with diarrhea

  This study is testing if combining a low-FODMAP diet with the medication mirtazapine can help adults with diarrhea-predominant irritable bowel syndrome feel better and improve their quality of life.

  Recruiting Early Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06684470

• Vedolizumab to prevent ICI-related diarrhea or colitis in cancer patients

  This study tests whether vedolizumab can prevent immune checkpoint inhibitor–related diarrhea or colitis in adults with unresectable or metastatic melanoma, lung, or kidney cancer starting immunotherapy.

  Recruiting Phase 2/3 AHS Cancer Control Alberta · Calgary, Alberta and 1 other locations · NCT06337695

• Using fecal microbiota transplantation to treat diarrhea and colitis from cancer immunotherapy

  This study tests if a stool transplant can help people with melanoma or kidney cancer who are having severe diarrhea and colitis from their immunotherapy treatment.

  Recruiting University of Aarhus · Aarhus N · NCT06206707

• Understanding gastrointestinal disorders in at-risk infants

  This study looks at how common gut problems are in at-risk infants, like those born early or who had trouble at birth, to see how these issues affect their growth and health in the first two years of life.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06031025

• Targeted water, sanitation, and hygiene intervention for cholera prevention

  This study is testing a new water, sanitation, and hygiene program to see if it can help people living near cholera patients stay healthy and reduce infections.

  Recruiting at 2 sites Johns Hopkins Bloomberg School of Public Health · Dhaka and 1 other locations · NCT06003816

• Fecal microbiota transplantation for treating irritable bowel syndrome

  This study is testing if using stool from a healthy donor can help people with irritable bowel syndrome feel better by restoring a healthy balance of gut bacteria.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT05776914

• Mesalamine to prevent colitis from ipilimumab plus nivolumab

  This trial will try giving mesalamine to adults with advanced melanoma who are starting ipilimumab plus nivolumab to see if it lowers the chance and severity of immune-related diarrhea and colitis.

  Recruiting Phase 2 AHS Cancer Control Alberta · Edmonton, Alberta · NCT05663775

• Nutritional supplements to prevent diarrhea in malnourished children

  This study is testing if milk-based nutritional supplements can help prevent diarrhea and improve recovery in malnourished children aged 6-24 months who have been hospitalized.

  Recruiting at 4 sites Phase 3 University of Washington · Homa Bay and 3 other locations · NCT05519254

• Using fecal microbiota transplantation to treat diarrhea or colitis in cancer patients

  This study is testing whether a treatment using healthy gut bacteria can help cancer patients with diarrhea or colitis caused by their cancer treatment feel better.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT04038619

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy

  A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11620095

• PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy

  Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11415441

• Mobile health tool to guide dehydration care for acute diarrhea across all ages

  A mobile app uses AI to help people of all ages determine dehydration risk during acute diarrhea and guide rehydration decisions.

  NIH research Brown University · Providence, United States · NIH-11402034

• Understanding how certain gut bacteria cause diarrhea in children and how it works in the gut lining

  This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.

  NIH research Indian Institute of Science · Bengaluru, India · NIH-11389289

• Targeting a gut transporter to help relieve constipation in CF and older adults

  Aimed at helping people with cystic fibrosis and older adults who have chronic constipation by studying a gut transporter to improve intestinal fluid balance.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11337500

• Targeting gut drug processing to prevent diarrhea from mycophenolate

  This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.

  NIH research Texas Southern University · Houston, United States · NIH-11325433

• How families and communities shape kids’ chest infections and diarrhea

  This grant studies how a child’s home and neighborhood—like family education, housing, water, and access to care—affects rates of acute respiratory infections and diarrhea in young children.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11319893

• PediCODE: consortium and biorepository for congenital diarrhea and enteropathy

  This project builds a patient network and sample bank to find genetic causes of congenital diarrhea in children.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11196739

• How family disadvantages affect young children's health during illnesses

  This study looks at how ongoing challenges like poverty and discrimination affect the health of young children, especially when it comes to illnesses like colds and diarrhea, and it aims to understand how these issues impact their access to healthcare.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11170626

• How certain E. coli cause severe diarrhea and gut inflammation

  This research looks at how toxins from some E. coli make the intestines inflamed and cause long diarrhea, especially in young children.

  NIH research Indian Institute of Science · Bengaluru, India · NIH-11136275

• Improving gut health to reduce diarrhea caused by a common transplant medication

  This study is looking at ways to help organ transplant patients who experience diarrhea from their medication, mycophenolate mofetil, by testing natural compounds that might make the side effects better while keeping the medicine effective.

  NIH research Texas Southern University · Houston, United States · NIH-11115565

• Understanding and Treating Constipation in Cystic Fibrosis and Older Adults

  This research explores new ways to help patients with cystic fibrosis and older adults who experience chronic constipation.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11092905

• Understanding how noroviruses cause diarrhea

  This study is looking at how noroviruses cause diarrhea by seeing how they impact immune cells in the intestines, especially comparing young and adult mice, to help find better treatments for people who get sick from these viruses.

  NIH research University of Florida · Gainesville, United States · NIH-11088760

• Better tools for managing diarrhea in children

  This project creates new digital tools to help doctors make better decisions about treating diarrhea in children, both in places with many resources and those with few.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11084404

• Improving treatment for pediatric diarrhea

  This study is working to improve how we treat diarrhea in kids under 11, helping doctors know when antibiotics are really needed and finding ways to use them wisely, all while training new researchers to better understand and tackle this serious health issue.

  NIH research University of Utah · Salt Lake City, United States · NIH-11078777

• Understanding the effects of non-dysentery Shigella diarrhea in children

  This study is looking at how a type of bacteria that causes watery diarrhea in kids affects their health, especially in poorer areas, and it aims to find a quick test to help doctors treat these infections faster, so children can get better sooner.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11037892

• Identifying biomarkers for diarrhea-predominant irritable bowel syndrome using stool samples

  This study is looking to make it easier to diagnose diarrhea-predominant irritable bowel syndrome (IBS-D) by checking stool samples for certain markers, so if you have IBS-D, researchers want to find a simple and non-invasive way to help identify your condition better.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11013340

• Using milk-derived supplements to help children recover from diarrhea and malnutrition

  This study is looking at whether two milk-based supplements, lactoferrin and lysozyme, can help young children aged 6 to 24 months recover faster from diarrhea and malnutrition after being in the hospital.

  NIH research University of Washington · Seattle, United States · NIH-10991382

• Understanding rare genetic causes of congenital diarrhea in children

  This study is looking for the genetic reasons behind congenital diarrhea and enteropathy in kids under 11, so if your child has this condition, researchers want to gather information and samples to help find better ways to understand and diagnose these rare disorders.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10978459

• Understanding how certain bacteria cause diarrhea and gut inflammation in children

  This study is looking at how a type of bacteria called ETEC causes diarrhea and gut problems in young children, with the hope of finding new treatments to help them feel better.

  NIH research Indian Institute of Science · Bangalore, India · NIH-10909970

• Investigating antibiotic use in children with diarrhea in China and its link to antibiotic resistance

  This study looks at how and why doctors and parents in China give antibiotics to kids under 11 with diarrhea, even when they might not need them, to help find better ways to use these medicines wisely and keep them effective for everyone.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10897223

• Investigating how certain dietary sugars affect diarrhea in IBS patients

  This study is looking at how certain carbohydrates called FODMAPs affect people with diarrhea-predominant Irritable Bowel Syndrome (IBS-D) and aims to find out how a low FODMAP diet can help ease their symptoms, so patients may be asked to try different diets and share their experiences.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10894002

• Creating a diary tool to track symptoms of diarrhea in irritable bowel syndrome.

  This study is creating a helpful diary tool for people with diarrhea-predominant irritable bowel syndrome (IBS-D) to track their symptoms and experiences, so that we can better understand their needs and improve treatment options.

  NIH research Critical Path Institute · Tucson, United States · NIH-10833930

• Comparing two types of oral rehydration solutions for treating severe diarrhea in adults

  This study is looking at whether a new drink with added calcium can help adults with acute watery diarrhea recover faster than the usual rehydration drink, and we're inviting people with this condition to see how well it works!

  NIH research University of Florida · Gainesville, United States · NIH-10761797

• Understanding why children with diarrhea often don't receive the right treatment.

  This study looks at why doctors in low- and middle-income countries sometimes don’t give children with diarrhea the lifesaving treatment of oral rehydration salts, even though it works well, and it aims to find out what influences their choices so we can help improve care for these kids.

  NIH research Rand Corporation · Santa Monica, United States · NIH-10649723

Related topics

Quick answers

How many Diarrhea clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (9 trials), Canada (3 trials), Turkey (Türkiye) (2 trials), China (2 trials), Uganda (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 3, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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