Identifying biomarkers for diarrhea-predominant irritable bowel syndrome using stool samples
Profiling diarrhea-predominant irritable bowel syndrome (IBS-D) using stool-based RNAs
This study is looking to make it easier to diagnose diarrhea-predominant irritable bowel syndrome (IBS-D) by checking stool samples for certain markers, so if you have IBS-D, researchers want to find a simple and non-invasive way to help identify your condition better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11013340 on NIH RePORTER |
What this research studies
This research aims to improve the diagnosis of diarrhea-predominant irritable bowel syndrome (IBS-D) by analyzing stool samples for specific RNA biomarkers. The approach involves sequencing RNA from exfoliated gut cells and studying the gut microbiome to identify changes associated with IBS-D. By comparing these findings in patient cohorts against healthy individuals, the researchers hope to develop a non-invasive method for diagnosing and classifying IBS-D, which currently lacks reliable diagnostic tests.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience symptoms of diarrhea-predominant irritable bowel syndrome.
Not a fit: Patients with other gastrointestinal disorders or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and non-invasive diagnostic methods for patients suffering from IBS-D.
How similar studies have performed: Previous research has shown promise in using stool-based biomarkers for gastrointestinal conditions, suggesting potential success for this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wang, Harris H — Columbia University Health Sciences
- Study coordinator: Wang, Harris H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.