Understanding the effects of non-dysentery Shigella diarrhea in children
Official title: The impact of non-dysentery Shigella-associated diarrhea in children
Funded at Johns Hopkins University · NIH-11037892 · Data updated 2026-11-12
This study is looking at how a type of bacteria that causes watery diarrhea in kids affects their health, especially in poorer areas, and it aims to find a quick test to help doctors treat these infections faster, so children can get better sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 9, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $722,477 |
| NIH project number | 5R01AI153399-05 |
| Project ID | NIH-11037892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 12 years old who are experiencing diarrhea and are seeking care in a hospital setting.
✕Less likely to help
Patients who do not have diarrhea or are older than 12 years may not benefit from this research.
What this research studies
This research investigates the impact of non-dysentery Shigella infections, which cause watery diarrhea in children, particularly in impoverished areas. The study aims to identify these infections quickly using a rapid diagnostic test, allowing for timely antibiotic treatment that could improve survival and long-term health outcomes. By comparing children with non-dysentery Shigella to those with dysentery, the research seeks to better understand the severity and implications of these infections. The study will be conducted in a hospital setting in Bangladesh, focusing on children under 12 years old.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for children suffering from non-dysentery Shigella infections, potentially saving lives and enhancing developmental outcomes.
How similar studies have gone: Previous research has shown that timely identification and treatment of bacterial infections can significantly improve patient outcomes, suggesting a promising avenue for this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Chakraborty, Subhra — Johns Hopkins University
- Study coordinator: Chakraborty, Subhra
Related research
Other NIH-funded projects on the same topics.
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PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
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PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
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This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.