Condition

Advanced Melanoma clinical trials and research

• 24Clinical trials
• 1NIH research projects
• 33Countries

Newest Advanced Melanoma clinical trials

All recruiting trials (24)

• Sitagliptin Plus Pembrolizumab in Advanced Renal Cell Carcinoma and Melanoma

  This study tests whether adding sitagliptin to pembrolizumab is safe and might help people whose advanced kidney cancer or melanoma stopped responding to prior PD-1/PD-L1 therapy.

  Recruiting Phase 1 University of Iowa · Iowa City, Iowa · NCT07634380

• MELCHRONO: Chrono-immunotherapy timing for advanced melanoma

  This study tests whether giving immune checkpoint inhibitors at specific times of day improves outcomes for adults with advanced melanoma.

  Recruiting at 9 sites Phase 2 Swiss Cancer Institute · Fribourg, Canton of Fribourg and 8 other locations · NCT07574047

• Intratumoral Au-TMP with Radiotherapy and Anti-PD-1 (Toripalimab) for Advanced Melanoma

  This trial will test whether a melanoma-targeted gold nanoparticle injected into tumors, combined with focused radiotherapy and the anti-PD-1 drug toripalimab, is safe for adults with unresectable advanced melanoma.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan and 1 other locations · NCT07562841

• Using ctDNA to decide whether to add ipilimumab for people on nivolumab and relatlimab

  This tests whether using a ctDNA blood test to guide adding ipilimumab for adults with advanced or metastatic melanoma on nivolumab and relatlimab leads to longer progression-free survival.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT07504796

• Morning versus afternoon immunotherapy for advanced or metastatic solid tumors

  This trial tests whether giving standard immune checkpoint inhibitor therapy in the morning versus the afternoon changes outcomes for adults with advanced or metastatic solid tumors.

  Recruiting Phase 4 OHSU Knight Cancer Institute · Portland, Oregon · NCT07405086

• LM103 treatment for advanced melanoma (Phase II)

  This study will test whether LM103 tumor‑infiltrating lymphocytes (TIL) given with chemotherapy can help adults with advanced melanoma who have not responded to at least two prior treatments.

  Recruiting at 16 sites Phase 2 Suzhou BlueHorse Therapeutics Co., Ltd. · Beijing, Beijing Municipality and 15 other locations · NCT07310784

• LBL-024 alone or combined with LBL-007 or toripalimab for advanced melanoma

  This research will test whether LBL-024, given alone or with LBL-007 or with the PD-1 drug toripalimab, helps people with advanced melanoma.

  Recruiting at 10 sites Phase 1/2 Nanjing Leads Biolabs Co.,Ltd · Beijing, Beijing Municipality and 15 other locations · NCT07099430

• AB821 for adults with advanced melanoma and other immune-responsive solid tumors

  This will test whether AB821 given every two weeks is safe and shows early anti-tumor activity in adults with recurrent locally advanced or metastatic melanoma or other immune-responsive solid tumors.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07027488

• Using modified T cells to treat advanced melanoma and sarcoma

  This study is testing a new treatment that uses modified T-cells to see if it can help people with advanced melanoma and sarcoma fight their cancer better.

  Recruiting Phase 1 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud and 1 other locations · NCT06889766

• Evaluating EIK1001 with Pembrolizumab for Advanced Melanoma

  This study is testing if a new drug called EIK1001, when combined with Pembrolizumab, can help people with advanced melanoma feel better compared to just using Pembrolizumab alone.

  Recruiting at 125 sites Phase 2/3 Eikon Therapeutics · Chandler, Arizona and 126 other locations · NCT06697301

• Testing a new combination treatment for advanced melanoma

  This study is testing a new combination of three treatments for people with advanced melanoma that hasn't improved with other therapies to see if it can help them feel better.

  Recruiting at 12 sites Phase 2 Memorial Sloan Kettering Cancer Center · Los Angeles, California and 11 other locations · NCT06594991

• Using focused ultrasound and an immune-activating drug for advanced melanoma treatment

  This study is testing a new treatment that combines focused ultrasound and an immune-boosting drug to see if it can help adults with advanced melanoma before their surgery.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06472661

• High-intensity exercise and high-fiber diet for melanoma patients

  This study is testing whether high-intensity exercise and a high-fiber diet can help improve health for melanoma patients receiving immunotherapy.

  Recruiting Fred Hutchinson Cancer Center · Boston, Massachusetts and 1 other locations · NCT06298734

• Neoadjuvant and adjuvant immunotherapy for advanced melanoma

  This study is testing if a new type of immunotherapy can help people with advanced melanoma do better before and after surgery.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06295159

• Comparing VO and Nivolumab to Standard Treatment for Advanced Melanoma

  This study is testing if a new combination of treatments, Vusolimogene Oderparepvec and nivolumab, can help people with advanced melanoma who haven't responded to other therapies feel better compared to standard treatments.

  Recruiting at 75 sites Phase 3 Replimune, Inc. · Gilbert, Arizona and 80 other locations · NCT06264180

• Testing T3011 for advanced melanoma treatment

  This study is testing a new treatment called T3011 to see if it can help people with advanced melanoma feel better and manage their condition.

  Recruiting at 7 sites Phase 1/2 Shanghai Pharmaceuticals Holding Co., Ltd · Beijing and 6 other locations · NCT06214156

• Comparing two treatments for advanced melanoma

  This study is testing if a new combination treatment for advanced melanoma can work better than the standard treatment for patients who have not received treatment before.

  Recruiting at 201 sites Phase 3 Immunocore Ltd · Tucson, Arizona and 210 other locations · NCT06112314

• At-home cancer treatment versus clinic-based treatment for advanced cancer patients

  This study tests whether giving cancer treatment at home is better for comfort and satisfaction compared to getting it at a clinic for people with advanced cancer.

  Recruiting at 2 sites Phase 2 Mayo Clinic · Jacksonville, Florida and 1 other locations · NCT05969860

• Combining Naltrexone and Propranolol with Immunotherapy for Advanced Melanoma

  This study is testing if combining two medications, naltrexone and propranolol, with immune therapy can help people with advanced melanoma feel better and improve their treatment results.

  Recruiting Phase 1 Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT05968690

• Mesalamine to prevent colitis from ipilimumab plus nivolumab

  This trial will try giving mesalamine to adults with advanced melanoma who are starting ipilimumab plus nivolumab to see if it lowers the chance and severity of immune-related diarrhea and colitis.

  Recruiting Phase 2 AHS Cancer Control Alberta · Edmonton, Alberta · NCT05663775

• Using memory-like natural killer cells with nivolumab and relatlimab for advanced melanoma after previous treatments

  This study is testing if a new type of immune cell treatment combined with two existing drugs can help people with advanced melanoma who haven't improved with previous therapies.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT05629546

• Comparing tebentafusp treatment to standard care for advanced melanoma

  This study is testing a new treatment called tebentafusp for people with advanced melanoma to see if it works better than the usual care they’ve already received.

  Recruiting at 82 sites Phase 3 Immunocore Ltd · Phoenix, Arizona and 81 other locations · NCT05549297

• Using tumor infiltrating lymphocytes to treat advanced melanoma

  This study is testing if a new treatment using immune cells from patients' own tumors can help people with advanced melanoma who haven't had success with other therapies.

  Recruiting Early Phase 1 Shanghai Juncell Therapeutics · Shanghai · NCT05098184

• Treatment of advanced solid tumors with IACS-6274 and other medications

  This study is testing a new drug called IACS-6274, alone and with other medications, to see how well it can help people with advanced solid tumors and what the safest dose is.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT05039801

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating personalized cancer vaccines for advanced melanoma patients

  This study is testing a personalized cancer vaccine for people with advanced melanoma to help their immune system better fight the cancer, using unique pieces from their own tumors along with other treatments to see how well it works.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10689220

Related topics

Quick answers

How many Advanced Melanoma clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 33 countries. The most sites are in United States (16 trials), Switzerland (5 trials), China (5 trials), Canada (4 trials), France (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 7, Phase 2: 7, Phase 3: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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