PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
Official title: COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
Funded at University of California Los Angeles · NIH-11620095 · Data updated 2026-11-12
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $341,950 |
| NIH project number | 3RC2DK118640-08S1 |
| Project ID | NIH-11620095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents diagnosed with Congenital Diarrhea and Enteropathy or suspected monogenic CoDE disorders, and their biological samples for biorepository contribution.
✕Less likely to help
Individuals without CoDE or without enrollment in a related center's biorepository contributions are unlikely to benefit directly from this grant.
What this research studies
This project creates a multi-center consortium and biorepository to identify monogenic causes of Congenital Diarrhea and Enteropathy (CoDE) by collecting detailed patient data, genes, tissues, and patient-derived cells. Researchers will develop protein-interactome and single-cell transcriptomic data from biopsies and build computational tools to analyze these data. The initiative will enroll CoDE patients, expand the clinical database, and enable mechanistic studies of both known and novel CoDE genes. The resulting resource is intended to accelerate understanding and future therapeutic experiments for CoDE disorders.
Why it matters
Potential benefit: If successful, patients with CoDE could receive faster genetic diagnosis, a deeper understanding of disease mechanisms, and access to future targeted therapies or clinical studies.
How similar studies have gone: Previous efforts to establish disease-focused biorepositories and multi-center cohorts have accelerated discovery in rare genetic disorders, though CoDE-specific work is emerging.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Martin, Martin G — University of California Los Angeles
- Study coordinator: Martin, Martin G
Related research
Other NIH-funded projects on the same topics.
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PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.
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-
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This grant studies how a child’s home and neighborhood—like family education, housing, water, and access to care—affects rates of acute respiratory infections and diarrhea in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.