Improving gut health to reduce diarrhea caused by a common transplant medication
Selectively Manipulating Intestinal Glucuronidation to Alleviate Mycophenolate mofetil-induced Diarrhea
This study is looking at ways to help organ transplant patients who experience diarrhea from their medication, mycophenolate mofetil, by testing natural compounds that might make the side effects better while keeping the medicine effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Southern University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11115565 on NIH RePORTER |
What this research studies
This research focuses on enhancing the detoxification process in the intestines to alleviate diarrhea caused by mycophenolate mofetil (MMF), a medication used by organ transplant patients. The researchers aim to selectively manipulate glucuronidation, a process that helps break down drugs, to reduce the side effects of MMF without affecting its effectiveness. By using animal models, they will test compounds like wogonin and chrysin that have shown promise in reducing MMF-induced diarrhea. The goal is to improve the quality of life for patients experiencing chronic diarrhea due to their medication.
Who could benefit from this research
Good fit: Ideal candidates for this research are organ transplant patients who are currently taking mycophenolate mofetil and experiencing chronic diarrhea.
Not a fit: Patients who are not on mycophenolate mofetil or do not suffer from diarrhea related to their medication may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for organ transplant patients by reducing medication-induced diarrhea.
How similar studies have performed: Previous studies have shown that manipulating glucuronidation can effectively reduce drug-related side effects, indicating potential success for this approach.
Where this research is happening
Houston, United States
- Texas Southern University — Houston, United States (Active)
Researchers
- Principal investigator: Gao, Song — Texas Southern University
- Study coordinator: Gao, Song
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.