Understanding how noroviruses cause diarrhea
Official title: Elucidation of Pathogenic Mechanisms underlying Norovirus Diarrhea
Funded at University of Florida · NIH-11088760 · Data updated 2026-11-12
This study is looking at how noroviruses cause diarrhea by seeing how they impact immune cells in the intestines, especially comparing young and adult mice, to help find better treatments for people who get sick from these viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | June 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $603,957 |
| NIH project number | 5R01AI162970-05 |
| Project ID | NIH-11088760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are experiencing severe diarrhea caused by norovirus, particularly children and young adults.
✕Less likely to help
Patients with chronic gastrointestinal conditions unrelated to norovirus may not benefit from this research.
What this research studies
This research investigates the mechanisms by which noroviruses lead to diarrhea, particularly focusing on how these viruses affect the immune cells in the intestines. Using a novel animal model, the study aims to explore the differences in disease severity between young and adult mice infected with murine norovirus. By examining the pathological changes in the intestinal epithelium and the immune response, the research seeks to uncover critical insights into norovirus infections. This could ultimately help in developing better treatments for those affected by norovirus-related illnesses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from norovirus infections.
How similar studies have gone: Previous research has shown success in using animal models to study viral infections, making this approach promising for understanding norovirus pathology.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Karst, Stephanie M — University of Florida
- Study coordinator: Karst, Stephanie M
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.