Understanding how noroviruses cause diarrhea
Elucidation of Pathogenic Mechanisms underlying Norovirus Diarrhea
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11088760
This study is looking at how noroviruses cause diarrhea by seeing how they impact immune cells in the intestines, especially comparing young and adult mice, to help find better treatments for people who get sick from these viruses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11088760 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which noroviruses lead to diarrhea, particularly focusing on how these viruses affect the immune cells in the intestines. Using a novel animal model, the study aims to explore the differences in disease severity between young and adult mice infected with murine norovirus. By examining the pathological changes in the intestinal epithelium and the immune response, the research seeks to uncover critical insights into norovirus infections. This could ultimately help in developing better treatments for those affected by norovirus-related illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing severe diarrhea caused by norovirus, particularly children and young adults.
Not a fit: Patients with chronic gastrointestinal conditions unrelated to norovirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from norovirus infections.
How similar studies have performed: Previous research has shown success in using animal models to study viral infections, making this approach promising for understanding norovirus pathology.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARST, STEPHANIE M — UNIVERSITY OF FLORIDA
- Study coordinator: KARST, STEPHANIE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection