Understanding and Treating Constipation in Cystic Fibrosis and Older Adults
Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea
This research explores new ways to help patients with cystic fibrosis and older adults who experience chronic constipation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11092905 on NIH RePORTER |
What this research studies
Many patients with cystic fibrosis face ongoing digestive problems, including severe constipation, due to issues with a protein called CFTR. Additionally, chronic constipation is a common concern for a significant portion of the general population, especially older adults. This project aims to understand how certain protein complexes in the gut, called CFTR-MRP4, contribute to these constipation issues. By studying cells from patients, we hope to find new ways to restore normal fluid balance in the intestines and relieve constipation.
Who could benefit from this research
Good fit: Ideal candidates for future related studies might include patients with cystic fibrosis experiencing gastrointestinal complications and older adults with chronic constipation.
Not a fit: Patients without cystic fibrosis-related gastrointestinal issues or chronic constipation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that alleviate or even cure chronic constipation for individuals with cystic fibrosis and the elderly.
How similar studies have performed: This research builds upon previous findings and preliminary data, suggesting a foundation of prior work in this area.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Naren, Anjaparavanda P — Cedars-Sinai Medical Center
- Study coordinator: Naren, Anjaparavanda P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.