PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
Official title: COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
Funded at University of California Los Angeles · NIH-11415441 · Data updated 2026-11-12
Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $341,950 |
| NIH project number | 3RC2DK118640-07S1 |
| Project ID | NIH-11415441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants and children with lifelong or early-onset chronic diarrhea or enteropathy, especially when a single-gene cause is suspected and families can provide clinical information and biological samples.
✕Less likely to help
People without congenital or early-onset enteropathy, those whose condition is clearly non-genetic, or those unwilling to provide samples are unlikely to benefit directly from this project.
What this research studies
This project is building a network of pediatric centers to enroll children born with chronic diarrhea or intestinal disorders and gather detailed medical records and genetic data. Families may be asked to provide blood, biopsy tissue, and other samples that will be stored in a central biorepository. Researchers will make patient-derived intestinal organoids, run single-cell and protein interaction analyses, and use computational imaging tools to link lab findings with clinical features. The shared database and samples aim to speed gene discovery and support future studies into causes and treatments.
Why it matters
Potential benefit: If successful, this work could lead to faster genetic diagnoses, better counseling, and new targets for treatments for children with congenital diarrhea and enteropathy.
How similar studies have gone: Rare-disease consortia and the use of patient-derived organoids and genomic sequencing have previously found new disease genes, so this approach builds on methods that have shown success though many CoDE causes remain undiscovered.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Martin, Martin G — University of California Los Angeles
- Study coordinator: Martin, Martin G
Related research
Other NIH-funded projects on the same topics.
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PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
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This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.
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Aimed at helping people with cystic fibrosis and older adults who have chronic constipation by studying a gut transporter to improve intestinal fluid balance.
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Targeting gut drug processing to prevent diarrhea from mycophenolate
This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.
-
How families and communities shape kids’ chest infections and diarrhea
This grant studies how a child’s home and neighborhood—like family education, housing, water, and access to care—affects rates of acute respiratory infections and diarrhea in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.