PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11415441 on NIH RePORTER |
What this research studies
This project is building a network of pediatric centers to enroll children born with chronic diarrhea or intestinal disorders and gather detailed medical records and genetic data. Families may be asked to provide blood, biopsy tissue, and other samples that will be stored in a central biorepository. Researchers will make patient-derived intestinal organoids, run single-cell and protein interaction analyses, and use computational imaging tools to link lab findings with clinical features. The shared database and samples aim to speed gene discovery and support future studies into causes and treatments.
Who could benefit from this research
Good fit: Infants and children with lifelong or early-onset chronic diarrhea or enteropathy, especially when a single-gene cause is suspected and families can provide clinical information and biological samples.
Not a fit: People without congenital or early-onset enteropathy, those whose condition is clearly non-genetic, or those unwilling to provide samples are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to faster genetic diagnoses, better counseling, and new targets for treatments for children with congenital diarrhea and enteropathy.
How similar studies have performed: Rare-disease consortia and the use of patient-derived organoids and genomic sequencing have previously found new disease genes, so this approach builds on methods that have shown success though many CoDE causes remain undiscovered.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Martin, Martin G — University of California Los Angeles
- Study coordinator: Martin, Martin G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.