Condition

Irritable Bowel Syndrome clinical trials and research

• 50Clinical trials
• 25NIH research projects
• 21Countries

Newest Irritable Bowel Syndrome clinical trials

All recruiting trials (50)

• Liver Fat and Scarring in People Suspected of Non-Celiac Wheat Sensitivity

  This study looks to see if people with non-celiac wheat sensitivity have liver fat or fibrosis and how this relates to IBS/FD and celiac disease.

  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT07750535

• Repeated transcranial magnetic stimulation to treat diarrhea-predominant irritable bowel syndrome

  This study will test whether repeated transcranial magnetic stimulation (rTMS) can reduce diarrhea, abdominal pain, and improve quality of life in adults with IBS-D.

  Recruiting The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07581756

• Brenipatide (LY3537031) for IBS with constipation

  This trial will test whether brenipatide (LY3537031), given by a small under-the-skin injection, helps adults with IBS-C have less belly pain and more normal bowel movements compared with a placebo.

  Recruiting at 64 sites Phase 2 Eli Lilly and Company · Mesa, Arizona and 69 other locations · NCT07545772

• Brenipatide (LY3537031) treatment for adults with IBS‑D

  This will test whether brenipatide (LY3537031) given under the skin helps adults with IBS‑D reduce belly pain and improve stool consistency compared with placebo.

  Recruiting at 80 sites Phase 2 Eli Lilly and Company · Mesa, Arizona and 88 other locations · NCT07545759

• Camlipixant for IBS-D and IBS-M: a test in adults

  This study tests camlipixant versus placebo in adults with IBS with diarrhea or mixed IBS to see if it helps reduce symptoms and is safe.

  Recruiting at 114 sites Phase 2 GlaxoSmithKline · Anniston, Alabama and 113 other locations · NCT07519395

• Defining Objective Markers of Dietary Compliance in IBS

  This study tests whether a biomarker in stool or urine can reflect how much certain carbohydrates you eat, helping manage IBS.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07494968

• Comparing Trimedat 76.95 mg orally disintegrating tablets with Trimedat 100 mg tablets in healthy adults

  This will test if Trimedat 76.95 mg dissolving tablets work the same and are as safe as Trimedat 100 mg tablets when taken fasting by healthy adults.

  Recruiting Phase 1 Valenta Pharm JSC · Saint Petersburg · NCT07421011

• How inflammatory diseases change the way your body handles medicines.

  This study will see if inflammatory conditions like type 2 diabetes, IBD, or end-stage kidney disease change how common medicines are processed and increase the chance of side effects.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07360938

• Vivatlac synbiotic for gut bacteria in IBS

  We will test whether taking one Vivatlac synbiotic capsule daily for 12 weeks changes gut bacteria and helps adults with moderate to severe IBS.

  Recruiting at 2 sites The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz · Jarocin and 1 other locations · NCT07235228

• Daily Vivatlac synbiotic capsules for people with moderate-to-severe irritable bowel syndrome

  This trial will test whether taking one daily Vivatlac synbiotic capsule helps adults with moderate-to-severe irritable bowel syndrome feel better over 36 weeks.

  Recruiting at 3 sites The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz · Jarocin and 2 other locations · NCT07235215

• Glutamine supplement (DIELEN® Protect) to reduce IBS symptoms

  This will test whether a glutamine-containing supplement (DIELEN® Protect) can reduce symptoms in adults aged 18–75 with Rome IV‑defined IBS and an IBS‑SSS score above 175.

  Recruiting Phase 2 University Hospital, Rouen · Rouen, France · NCT07039747

• Using Transcranial Magnetic Stimulation and Probiotics to Treat IBS-D

  This study is testing if a combination of brain stimulation and probiotics can help people with diarrhea-predominant IBS feel better.

  Recruiting Phase 1 The First Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06960369

• Exercise and IBS-friendly diet program for people with fibromyalgia and IBS

  This trial tests whether a combined exercise program and an IBS-friendly diet can reduce pain and gut symptoms in adults aged 30–65 who have both fibromyalgia and moderate-to-severe IBS.

  Recruiting Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis · Castellana Grotte, Bari · NCT06923800

• Regional cohort for patients with irritable bowel syndrome

  This study is trying to learn more about irritable bowel syndrome by following around 600 patients for 2.5 years to see how the condition affects them and how it can be treated better.

  Recruiting University Hospital, Rouen · Amiens and 3 other locations · NCT06900491

• WISH 2.0: Strengths and Happiness program for people with IBS

  This trial will test a positive psychology program to see if it improves well-being and gut symptoms in adults with IBS compared with an educational program.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06866106

• Home-based ear (taVNS) stimulation for IBS pain

  This trial will test whether a home-based ear vagus nerve stimulation device, used twice daily for six weeks, helps reduce pain and symptoms in 18–29-year-olds with IBS compared with a look‑alike sham device.

  Recruiting Yale University · New Haven, Connecticut · NCT06847360

• Exploring gut microbes in adults with IBS and constipation who produce excess methane

  This study tests whether stool and blood samples show distinct gut microbes in adults with IBS and predominant constipation who have high methane on a breath test.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06801184

• Single low-dose esketamine for irritable bowel syndrome

  This will see if a single low dose of esketamine can quickly reduce IBS symptoms in adults with IBS who also have anxiety or depression and are scheduled for a colonoscopy.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06788444

• Exercise and its effects on sexual dysfunction in men with irritable bowel syndrome

  This study tests if regular elliptical exercise can help men with irritable bowel syndrome improve their sexual function and overall symptoms.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT06783894

• Digestive enzyme treatment for IBS patients who responded to a low FODMAP diet

  This study is testing if a digestive enzyme can help people with IBS who felt better on a low FODMAP diet but have had their symptoms come back after a year.

  Recruiting at 2 sites Attikon Hospital · Chaïdári, Athens and 1 other locations · NCT06749613

• Laughter yoga's effects on IBS symptoms and mental health

  This study is testing if laughter yoga can help people with Irritable Bowel Syndrome feel better and improve their mental health.

  Recruiting Ataturk University · Erzurum, Yakutiye · NCT06705153

• Using psyllium to treat irritable bowel syndrome in children

  This study is testing if taking psyllium fiber can help children with irritable bowel syndrome feel better after eating foods that contain fructans.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06639984

• Evaluating SMT04 for treating Irritable Bowel Syndrome

  This study is testing a new probiotic called SMT04 to see if it can help people with Irritable Bowel Syndrome feel better by improving their gut health.

  Recruiting Changi General Hospital · Singapore, Singapore · NCT06636513

• Effects of inulin and methylcellulose on gas production in the colon

  This study is testing whether eating meals with a mix of two types of fiber can help people with Irritable Bowel Syndrome feel less bloated and gassy.

  Recruiting at 2 sites University of Nottingham · Nottingham, Nottinghamshire and 1 other locations · NCT06551961

• Investigating Immune Reactions to Food in IBS Patients

  This study is trying to see how certain foods affect the immune system in people with Irritable Bowel Syndrome (IBS), especially those with a specific infection, to find out which foods might be causing their symptoms.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT06413004

• Video-guided training to reduce visible abdominal bloating

  This project tries a simple video-guided biofeedback program versus a sham program to see if it reduces visible belly swelling after meals in people with IBS, dyspepsia, or functional bloating.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Los Angeles, California and 6 other locations · NCT06369753

• Glutamine to improve the gut lining in people with diarrhea-predominant IBS and increased intestinal permeability

  This trial will test whether taking oral glutamine helps adults with diarrhea-predominant IBS who have increased intestinal permeability.

  Recruiting at 3 sites University Hospital, Rouen · Amiens and 3 other locations · NCT06291038

• Skin patch testing for food allergies in IBS patients

  This study is testing if skin patch tests for food allergies can help people with Irritable Bowel Syndrome better manage their symptoms by identifying foods they should avoid.

  Recruiting at 2 sites Ibs-80, LLC · North Wales, Pennsylvania and 1 other locations · NCT06288672

• Program for stress reduction and lifestyle changes in IBS patients

  This study is testing whether a 10-week program that combines stress reduction and lifestyle changes can help people with irritable bowel syndrome feel better and improve their quality of life.

  Recruiting Universität Duisburg-Essen · Bamberg, Bavaria · NCT06145022

• Exploring the gut microbiome in IBS patients

  This study is testing how a low FODMAP diet affects the gut bacteria and symptoms of people with Irritable Bowel Syndrome (IBS).

  Recruiting Weizmann Institute of Science · Rehovot · NCT05972317

• Exploring treatments for Gulf War Illness-related gastrointestinal symptoms

  This study is testing if taking glutamine can help veterans with Gulf War Illness feel better by easing their stomach problems like pain and diarrhea.

  Recruiting VA Office of Research and Development · Memphis, Tennessee · NCT05972291

• Evaluating the DOMINO Diet App for Irritable Bowel Syndrome

  This study is testing if using the DOMINO diet app can help people with Irritable Bowel Syndrome manage their symptoms by following a low FODMAP diet.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT05808036

• Using fecal microbiota transplantation to treat constipation in IBS patients

  This study is testing whether a treatment using healthy gut bacteria can help people with irritable bowel syndrome who have constipation feel better.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT05803993

• Fecal microbiota transplantation for irritable bowel syndrome without constipation

  This study is testing whether a treatment called fecal microbiota transplantation can help people with irritable bowel syndrome who don’t have constipation feel better.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT05803980

• Fecal microbiota transplantation for treating irritable bowel syndrome

  This study is testing if using stool from a healthy donor can help people with irritable bowel syndrome feel better by restoring a healthy balance of gut bacteria.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT05776914

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Fecal microbiota transplant for adults with refractory irritable bowel syndrome

  This project will try monthly fecal microbiota transplants—given as oral capsules or through a tube to the small intestine—to see if symptoms improve in adults (18–70) with IBS who haven't responded to at least three treatments.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT05740319

• Online program to help parents with IBS support their children

  This study is testing an online program to see if it can help parents with IBS support their young children and reduce their tummy pain.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT05730491

• Yoga and meditation program for stress reduction in adolescents with IBS

  This study is testing if a 6-week yoga and meditation program can help reduce stress and improve life for teens with Irritable Bowel Syndrome (IBS).

  Recruiting Cooper Norcross Health · Camden, New Jersey · NCT05719246

• Cardiovascular exercise for improving symptoms in IBS patients with a sedentary lifestyle

  This study is testing if regular cardiovascular exercise can help people with irritable bowel syndrome who don't get much physical activity feel better and improve their symptoms.

  Recruiting Universitair Ziekenhuis Brussel · Jette · NCT05680766

• Using probiotics to treat ulcerative colitis and irritable bowel syndrome

  This study is testing if adding probiotics to standard treatment can help people with mild to moderate ulcerative colitis and irritable bowel syndrome feel better.

  Recruiting The First Affiliated Hospital of Xinxiang Medical College · Xinxiang, Henan · NCT05652621

• Internet-based treatment for severe functional somatic disorders

  This study is testing a new online therapy program to see if it helps people with severe functional somatic disorders feel better compared to a different online program.

  Recruiting University of Aarhus · Aarhus C, Denmark · NCT05525598

• Assessing dietary intake and IBS symptoms using a food frequency questionnaire

  This study is testing a new food questionnaire to see how well it helps people, including those with IBS, understand their diet and its impact on their symptoms.

  Recruiting Universitair Ziekenhuis Brussel · Jette, Brussels Capital · NCT05293769

• Evaluating Anorectal Function in Patients with Inflammatory Bowel Disease

  This study is testing how well the muscles and nerves in the rectum work in people with inflammatory bowel disease to see if they have ongoing gut issues, even if they feel fine.

  Recruiting Region Örebro County · Örebro · NCT05185609

• Low FODMAP diet for treating moderate to severe IBS

  This study is testing if a low FODMAP diet can help people with moderate to severe IBS feel better by reducing symptoms like abdominal pain and bloating.

  Recruiting Phase 3 Universitair Ziekenhuis Brussel · Jette, Brussels Capital · NCT05120752

• Testing the effects of a lactose-free diet on IBS symptoms using breath tests

  This study is testing if a lactose-free diet can help people with moderate to severe IBS feel better by using breath tests to see if they have lactose intolerance.

  Recruiting Phase 3 Universitair Ziekenhuis Brussel · Jette, Brussels Capital · NCT04974593

• Observing functional digestive disorders

  This study is collecting health information and samples from people with digestive issues like irritable bowel syndrome to see if it can help find better treatments for them.

  Recruiting University Hospital, Rouen · Rouen · NCT04918329

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Using fecal microbiota transplantation to treat irritable bowel syndrome

  This study is testing whether using healthy gut bacteria from donors can help people with irritable bowel syndrome feel better.

  Recruiting Phase 2/3 Guangzhou First People's Hospital · Guangzhou, Guangdong · NCT03613545

• Understanding gut changes during Campylobacter infection

  This study looks at how a Campylobacter infection changes the gut and whether those changes can lead to long-term bowel problems like Irritable Bowel Syndrome in people who have had the infection.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03223077

NIH-funded research (25)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Proteolytic Activity-Guided Fecal Microbiota Transplant for PI-IBS

  A pilot study will test a targeted fecal microbiota transplant to help adults with post-infection irritable bowel syndrome feel better and have fewer GI symptoms.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11377587

• IBS after COVID-19: how SARS-CoV-2 infection may lead to irritable bowel syndrome

  This project explores whether people who had SARS-CoV-2 infection may develop IBS and what factors raise that risk.

  NIH research University of Arizona · Tucson, United States · NIH-11375083

• Psyllium with meals for fructan-triggered pain in children with IBS

  A small study in children with IBS will test whether adding psyllium with meals helps reduce tummy pain caused by fructan in certain foods.

  NIH research Duke University · Durham, United States · NIH-11374563

• VR-based CBT for IBS: at-home treatment idea with guided virtual reality therapy

  A pilot study will test whether a home-based VR cognitive behavioral therapy program helps people with irritable bowel syndrome feel better and manage symptoms compared with a sham VR experience.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11357696

• Understanding how alcohol and the gut’s serotonin system affect IBS

  This project looks at how alcohol and the gut’s serotonin system may influence irritable bowel syndrome (IBS) symptoms in people who have IBS.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11314772

• Sex differences in how the brain, gut, and microbes interact in IBS

  A large NIH grant is studying how sex differences in brain–gut–microbiome interactions relate to IBS and its related symptoms, with a focus on women.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11303027

• Abdominal Myofascial Release for IBS-C in patients of all ages

  A study tests a hands-on therapy called abdominal myofascial release to help kids, teens, and adults with IBS with constipation feel better and have fewer tummy symptoms.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11287557

• New oral therapy for IBS-related abdominal pain using a TNF-α–neutralizing probiotic

  A new oral biotherapeutic pill made from a probiotic yeast targets gut inflammation to relieve chronic abdominal pain in people with irritable bowel syndrome.

  NIH research Fzata, INC. · Halethorpe, United States · NIH-11190585

• A new way to use gut bacteria transplants for Irritable Bowel Syndrome

  This research explores if a special type of fecal microbiota transplant, guided by specific gut enzyme activity, can safely and effectively improve symptoms for adults with Irritable Bowel Syndrome that developed after an infection.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11176806

• Psyllium with Meals for Children with IBS and Fructan Sensitivity

  This project explores if adding psyllium to meals can help children with Irritable Bowel Syndrome who are sensitive to fructans, a type of carbohydrate.

  NIH research Duke University · Durham, United States · NIH-11159484

• How missing gut bacteria may drive post-infection irritable bowel syndrome

  This project aims to restore missing gut bacteria in adults with post-infection IBS to reduce harmful protein‑breaking enzymes that may cause gut damage and symptoms.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11144404

• Using virtual reality to help manage irritable bowel syndrome symptoms

  This study is looking at whether a virtual reality program that offers therapy can help people with irritable bowel syndrome (IBS) manage their tummy pain and feel better overall, making it a convenient option for those who might not have easy access to traditional therapy.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11140550

• Improving symptoms of irritable bowel syndrome through positive psychology techniques

  This study is looking at how positive thinking exercises can help people with irritable bowel syndrome (IBS) feel better mentally and emotionally, using a friendly 9-week phone program called 'WISH' to see if it works better than just learning about IBS.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11136630

• Using a device at home to stimulate a nerve in the ear to help manage pain in young adults with IBS

  This study is looking at whether a gentle ear stimulation technique done at home can help young adults with irritable bowel syndrome (IBS) feel better by easing their pain and symptoms.

  NIH research Yale University · New Haven, United States · NIH-11122461

• Understanding how diet and gut movement affect irritable bowel syndrome symptoms

  This study is looking at how what you eat affects your gut movement if you have irritable bowel syndrome (IBS), using a special patch to track your gut activity and symptoms for a week while you keep a food diary, with the hope of finding out which foods might be causing your issues to help improve treatment options.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11057116

• Identifying biomarkers for diarrhea-predominant irritable bowel syndrome using stool samples

  This study is looking to make it easier to diagnose diarrhea-predominant irritable bowel syndrome (IBS-D) by checking stool samples for certain markers, so if you have IBS-D, researchers want to find a simple and non-invasive way to help identify your condition better.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11013340

• A new oral treatment for chronic pain in irritable bowel syndrome

  This study is testing a new oral treatment made from a special probiotic yeast that aims to help people with irritable bowel syndrome (IBS) by reducing chronic pain and improving their overall gut health.

  NIH research Fzata, INC. · Halethorpe, United States · NIH-10976389

• Investigating how sex differences affect brain-gut interactions in irritable bowel syndrome.

  This study is looking at how hormones, gut bacteria, and brain activity work together to affect symptoms in women with irritable bowel syndrome (IBS) and chronic constipation, hoping to find better treatments that fit each person's unique situation.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10903897

• Investigating how gut bacteria affect irritable bowel syndrome after infections

  This study is looking at how certain gut bacteria might play a role in causing irritable bowel syndrome (IBS) after an intestinal infection, and it aims to find ways to improve gut health and ease IBS symptoms for people who have experienced this condition.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10896327

• Investigating how certain dietary sugars affect diarrhea in IBS patients

  This study is looking at how certain carbohydrates called FODMAPs affect people with diarrhea-predominant Irritable Bowel Syndrome (IBS-D) and aims to find out how a low FODMAP diet can help ease their symptoms, so patients may be asked to try different diets and share their experiences.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10894002

• Exploring gut bacteria and metabolites to find new types of Irritable Bowel Syndrome

  This study is looking at how the bacteria in your gut and their byproducts can help us understand the different types of Irritable Bowel Syndrome (IBS) and find better ways to treat it, so if you have IBS, your participation could help improve your care!

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10848525

• Creating a diary tool to track symptoms of diarrhea in irritable bowel syndrome.

  This study is creating a helpful diary tool for people with diarrhea-predominant irritable bowel syndrome (IBS-D) to track their symptoms and experiences, so that we can better understand their needs and improve treatment options.

  NIH research Critical Path Institute · Tucson, United States · NIH-10833930

• Mindfulness meditation training for managing Irritable Bowel Syndrome symptoms

  This study is looking at how mindfulness meditation can help people with Irritable Bowel Syndrome (IBS) feel better by teaching them to accept their symptoms, and it’s open to anyone who wants to try out mindfulness techniques through apps or group sessions.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-10833558

• Using targeted fecal microbiota transplantation to treat irritable bowel syndrome

  This study is looking at whether a special treatment called fecal microbiota transplantation (FMT) can help people with irritable bowel syndrome (IBS) who started having symptoms after an intestinal infection, by using healthy gut bacteria from carefully chosen donors to improve their gut health.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10773350

• Identifying new subtypes of irritable bowel syndrome using gut bacteria and metabolites.

  This study is looking at how the bacteria in your gut and their byproducts can help us understand the different types of irritable bowel syndrome (IBS) and figure out which treatments might work best for you.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10579289

Related topics

Quick answers

How many Irritable Bowel Syndrome clinical trials are recruiting right now?

50, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (16 trials), China (8 trials), Belgium (7 trials), France (6 trials), Italy (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 2, Phase 1: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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