Investigating how certain dietary sugars affect diarrhea in IBS patients
Role of FODMAPs in the pathophysiology of diarrhea-predominant Irritable bowel syndrome
This study is looking at how certain carbohydrates called FODMAPs affect people with diarrhea-predominant Irritable Bowel Syndrome (IBS-D) and aims to find out how a low FODMAP diet can help ease their symptoms, so patients may be asked to try different diets and share their experiences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10894002 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of FODMAPs, a group of fermentable carbohydrates, in causing symptoms of diarrhea-predominant Irritable Bowel Syndrome (IBS-D). The study aims to identify the mechanisms by which high FODMAP diets exacerbate symptoms and how low FODMAP diets can provide relief for many patients. By examining changes in gut bacteria and the colonic barrier function, the research seeks to develop targeted therapies that could improve treatment outcomes for IBS-D patients. Patients may be involved in dietary interventions and assessments to help clarify these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diarrhea-predominant Irritable Bowel Syndrome (IBS-D).
Not a fit: Patients with other forms of Irritable Bowel Syndrome or those without IBS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective dietary recommendations and treatments for patients suffering from IBS-D.
How similar studies have performed: Previous research has shown that dietary interventions, particularly low FODMAP diets, can significantly improve symptoms in IBS patients, indicating a promising avenue for further exploration.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Singh, Prashant — University of Michigan at Ann Arbor
- Study coordinator: Singh, Prashant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.