Investigating how certain dietary sugars affect diarrhea in IBS patients

Who could benefit from this research

What this research studies

This research focuses on understanding the role of FODMAPs, a group of fermentable carbohydrates, in causing symptoms of diarrhea-predominant Irritable Bowel Syndrome (IBS-D). The study aims to identify the mechanisms by which high FODMAP diets exacerbate symptoms and how low FODMAP diets can provide relief for many patients. By examining changes in gut bacteria and the colonic barrier function, the research seeks to develop targeted therapies that could improve treatment outcomes for IBS-D patients. Patients may be involved in dietary interventions and assessments to help clarify these mechanisms.

Why it matters

Where this research is happening

• University of Michigan at Ann Arbor
  Ann Arbor, United States Active

Researchers

• Principal investigator: Singh, Prashant — University of Michigan at Ann Arbor
• Study coordinator: Singh, Prashant

Related research

Other NIH-funded projects on the same topics.

• Identifying biomarkers for diarrhea-predominant irritable bowel syndrome using stool samples

  This study is looking to make it easier to diagnose diarrhea-predominant irritable bowel syndrome (IBS-D) by checking stool samples for certain markers, so if you have IBS-D, researchers want to find a simple and non-invasive way to help identify your condition better.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11013340

• Creating a diary tool to track symptoms of diarrhea in irritable bowel syndrome.

  This study is creating a helpful diary tool for people with diarrhea-predominant irritable bowel syndrome (IBS-D) to track their symptoms and experiences, so that we can better understand their needs and improve treatment options.

  NIH research Critical Path Institute · Tucson, United States · NIH-10833930

• PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy

  A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11620095

• PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy

  Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11415441

• Mobile health tool to guide dehydration care for acute diarrhea across all ages

  A mobile app uses AI to help people of all ages determine dehydration risk during acute diarrhea and guide rehydration decisions.

  NIH research Brown University · Providence, United States · NIH-11402034

• Understanding how certain gut bacteria cause diarrhea in children and how it works in the gut lining

  This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.

  NIH research Indian Institute of Science · Bengaluru, India · NIH-11389289

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.