Targeting a gut transporter to help relieve constipation in CF and older adults

Who could benefit from this research

What this research studies

This project explores how blocking a specific gut transporter might restore fluid balance in the intestines of people with CF-related constipation and in the general aging population. Researchers will use stem-cell–derived intestinal cells from CF patients with constipation to study how CFTR and MRP4 interact and influence fluid secretion. The goal is to identify a way to target this transporter complex to ease constipation symptoms and improve gut function. The work builds on previous findings to understand signaling pathways and how secretory mechanisms might be restored in these groups.

Why it matters

Where this research is happening

• Cedars-Sinai Medical Center
  Los Angeles, United States Active

Researchers

• Principal investigator: Naren, Anjaparavanda P — Cedars-Sinai Medical Center
• Study coordinator: Naren, Anjaparavanda P

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.