How families and communities shape kids’ chest infections and diarrhea
Official title: Intergenerational disadvantage and pediatric health disparities in acute respiratory illness and diarrhea
Funded at University of Michigan at Ann Arbor · NIH-11319893 · Data updated 2026-11-12
This grant studies how a child’s home and neighborhood—like family education, housing, water, and access to care—affects rates of acute respiratory infections and diarrhea in young children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $667,725 |
| NIH project number | 5R01HD111446-03 |
| Project ID | NIH-11319893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children under five living in high-burden settings, and their families, whose households are willing to share information about living conditions and healthcare use.
✕Less likely to help
Families in settings with very limited data collection or where health services are not accessible may not experience direct benefits.
What this research studies
We’re looking at how things outside the clinic, such as parents’ education, housing quality, water and food safety, and local services, influence how often kids under five get respiratory infections or diarrhea and how they use health care. The project will collect community and household data in settings with high illness burdens and link those factors to disease outcomes and care-seeking patterns. By mapping where risk factors cluster and how care is accessed, the study aims to identify targets for interventions that could reduce illness and improve health for children. This work is designed to inform policies and programs that support families in preventing and managing early-life illnesses.
Why it matters
Potential benefit: If successful, the research could guide community and policy efforts to reduce childhood illness and improve access to timely care.
How similar studies have gone: Previous work has linked social and economic factors to child health, but this project aims to detail how neighborhood and household characteristics specifically influence respiratory and diarrheal diseases in high-burden areas.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Treleaven, Emily — University of Michigan at Ann Arbor
- Study coordinator: Treleaven, Emily
Related research
Other NIH-funded projects on the same topics.
-
PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
-
PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.
-
Mobile health tool to guide dehydration care for acute diarrhea across all ages
A mobile app uses AI to help people of all ages determine dehydration risk during acute diarrhea and guide rehydration decisions.
-
Understanding how certain gut bacteria cause diarrhea in children and how it works in the gut lining
This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.
-
Targeting a gut transporter to help relieve constipation in CF and older adults
Aimed at helping people with cystic fibrosis and older adults who have chronic constipation by studying a gut transporter to improve intestinal fluid balance.
-
Targeting gut drug processing to prevent diarrhea from mycophenolate
This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.