PediCODE: consortium and biorepository for congenital diarrhea and enteropathy
Official title: COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
Funded at University of California Los Angeles · NIH-11196739 · Data updated 2026-11-12
This project builds a patient network and sample bank to find genetic causes of congenital diarrhea in children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2019 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,658,050 |
| NIH project number | 5RC2DK118640-07 |
| Project ID | NIH-11196739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children (typically infants and young children) with congenital or early-onset severe diarrhea or enteropathy, especially when a genetic cause is suspected and families are willing to provide clinical information and samples.
✕Less likely to help
Patients whose diarrhea is due to common, transient, infectious, or non-genetic causes are less likely to receive direct benefit from this program.
What this research studies
If your child has congenital or early-onset severe diarrhea, this consortium will invite you to join a multi-center patient cohort and share medical records, genetic data, and tissue samples. Collected samples will be stored in a centralized biorepository and used for genetic sequencing, single-cell RNA studies, protein-interactome analyses, and lab-grown intestinal enteroids from biopsies. The team will apply computational and imaging tools to compare patient-derived samples and search for new disease-causing genes and biological mechanisms. These resources are intended to support lab research that could lead to better diagnoses and future targeted treatments.
Why it matters
Potential benefit: Could identify the genetic cause of a child's condition, improve diagnosis, and create a foundation for targeted therapies.
How similar studies have gone: Other rare-disease biobanks and gene-discovery programs have successfully identified causal genes, though applying these methods specifically across many CoDE disorders is still relatively new.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Martin, Martin G — University of California Los Angeles
- Study coordinator: Martin, Martin G
Related research
Other NIH-funded projects on the same topics.
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PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
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PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy
Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.
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Mobile health tool to guide dehydration care for acute diarrhea across all ages
A mobile app uses AI to help people of all ages determine dehydration risk during acute diarrhea and guide rehydration decisions.
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Understanding how certain gut bacteria cause diarrhea in children and how it works in the gut lining
This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.
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Targeting a gut transporter to help relieve constipation in CF and older adults
Aimed at helping people with cystic fibrosis and older adults who have chronic constipation by studying a gut transporter to improve intestinal fluid balance.
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Targeting gut drug processing to prevent diarrhea from mycophenolate
This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.