PediCODE: consortium and biorepository for congenital diarrhea and enteropathy
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository
This project builds a patient network and sample bank to find genetic causes of congenital diarrhea in children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11196739 on NIH RePORTER |
What this research studies
If your child has congenital or early-onset severe diarrhea, this consortium will invite you to join a multi-center patient cohort and share medical records, genetic data, and tissue samples. Collected samples will be stored in a centralized biorepository and used for genetic sequencing, single-cell RNA studies, protein-interactome analyses, and lab-grown intestinal enteroids from biopsies. The team will apply computational and imaging tools to compare patient-derived samples and search for new disease-causing genes and biological mechanisms. These resources are intended to support lab research that could lead to better diagnoses and future targeted treatments.
Who could benefit from this research
Good fit: Children (typically infants and young children) with congenital or early-onset severe diarrhea or enteropathy, especially when a genetic cause is suspected and families are willing to provide clinical information and samples.
Not a fit: Patients whose diarrhea is due to common, transient, infectious, or non-genetic causes are less likely to receive direct benefit from this program.
Why it matters
Potential benefit: Could identify the genetic cause of a child's condition, improve diagnosis, and create a foundation for targeted therapies.
How similar studies have performed: Other rare-disease biobanks and gene-discovery programs have successfully identified causal genes, though applying these methods specifically across many CoDE disorders is still relatively new.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Martin, Martin G — University of California Los Angeles
- Study coordinator: Martin, Martin G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.