Understanding rare genetic causes of congenital diarrhea in children

Who could benefit from this research

What this research studies

This research focuses on identifying the genetic causes of congenital diarrhea and enteropathy (CoDE) in children under 11 years old. By creating a consortium and biorepository, the project aims to collect clinical data and biological samples from affected patients. This will help researchers understand the clinical features and underlying mechanisms of these rare disorders. The study involves a multidisciplinary team of physician-scientists who will analyze patient samples to uncover genetic information and develop new diagnostic tools.

Why it matters

Where this research is happening

• University of California Los Angeles
  Los Angeles, United States Active

Researchers

• Principal investigator: Martin, Martin G — University of California Los Angeles
• Study coordinator: Martin, Martin G

Related research

Other NIH-funded projects on the same topics.

• PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy

  A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11620095

• PediCODE Consortium and Biobank for Congenital Diarrhea and Enteropathy

  Creating a multi-center team and biobank to find genetic causes of congenital diarrhea and enteropathy in children and collect samples that can help future research.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11415441

• Mobile health tool to guide dehydration care for acute diarrhea across all ages

  A mobile app uses AI to help people of all ages determine dehydration risk during acute diarrhea and guide rehydration decisions.

  NIH research Brown University · Providence, United States · NIH-11402034

• Understanding how certain gut bacteria cause diarrhea in children and how it works in the gut lining

  This project looks at how infections from ETEC and EPEC bacteria cause diarrhea, especially in children, and uses a mouse model and human-derived gut cell systems to uncover the underlying mechanisms.

  NIH research Indian Institute of Science · Bengaluru, India · NIH-11389289

• Targeting a gut transporter to help relieve constipation in CF and older adults

  Aimed at helping people with cystic fibrosis and older adults who have chronic constipation by studying a gut transporter to improve intestinal fluid balance.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11337500

• Targeting gut drug processing to prevent diarrhea from mycophenolate

  This project tests whether using natural gut-acting compounds to boost a specific drug-clearing pathway in the lower intestine can reduce diarrhea caused by the transplant drug mycophenolate in people who take it.

  NIH research Texas Southern University · Houston, United States · NIH-11325433

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.