Understanding how certain bacteria cause diarrhea and gut inflammation in children
Mechanisms underlying diarrhea and gut inflammation mediated by Enterotoxigenic and Enteropathogenic E. coli
['FUNDING_R01'] · INDIAN INSTITUTE OF SCIENCE · NIH-10909970
This study is looking at how a type of bacteria called ETEC causes diarrhea and gut problems in young children, with the hope of finding new treatments to help them feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIAN INSTITUTE OF SCIENCE (nih funded) |
| Locations | 1 site (BANGALORE, INDIA) |
| Trial ID | NIH-10909970 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which enterotoxigenic Escherichia coli (ETEC) leads to diarrhea and gut inflammation, particularly in children under five years old. The study focuses on how these bacteria produce toxins that affect gut function and contribute to severe diarrhea, which is a major health issue in developing countries. By using a pre-clinical model involving genetically modified mice, the researchers aim to uncover the underlying biological processes and identify potential therapeutic targets. The ultimate goal is to develop effective treatments for children suffering from these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of five who are experiencing moderate to severe diarrhea due to ETEC infections.
Not a fit: Patients who are older than five years or those with diarrhea caused by non-bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat diarrhea caused by ETEC in children, reducing morbidity and mortality.
How similar studies have performed: Previous research has shown promising results in understanding bacterial infections and their effects on gut health, but this specific approach using ETEC and its mechanisms is relatively novel.
Where this research is happening
BANGALORE, INDIA
- INDIAN INSTITUTE OF SCIENCE — BANGALORE, INDIA (ACTIVE)
Researchers
- Principal investigator: VISWESWARIAH, SANDHYA — INDIAN INSTITUTE OF SCIENCE
- Study coordinator: VISWESWARIAH, SANDHYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections