Condition

Cannabis clinical trials and research

• 17Clinical trials
• 394NIH research projects
• 4Countries

Newest Cannabis clinical trials

All recruiting trials (17)

• Cannabis Effects on Recognition Memory and Brain Waves in Regular Users

  This study tests how THC- and CBD-containing cannabis strains affect recognition memory and brain activity in regular cannabis users.

  Recruiting University of Colorado, Boulder · Boulder, Colorado · NCT07679581

• Hemp-based CBD topical lotion pharmacokinetics in healthy adults

  This study tests how a high‑CBD, low‑THC hemp lotion behaves in the body after short‑ and longer‑term use in healthy adults.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07603518

• Repeated CBD to change how cannabis affects mood and pain

  This study will test whether taking CBD repeatedly changes the behavioral effects and pain relief experienced by adult cannabis users.

  Recruiting Early Phase 1 University of Kentucky · Lexington, Kentucky · NCT07434895

• How menstrual-cycle hormones change women's responses to cannabis

  This study will see if occasional biological female cannabis users respond differently to a measured THC dose at three phases of their menstrual cycle compared with a placebo.

  Recruiting Maastricht University · Maastricht · NCT07417059

• Effect of cannabis oil on untreatable liver cancer

  This study tests whether cannabis oil can help people with untreatable liver cancer feel better by seeing if it affects their tumors.

  Recruiting Phase 2 University Medical Center Groningen · Groningen · NCT06518434

• Exploring how CBD affects THC's psychoactive effects

  This study is testing how different amounts of CBD can change the effects of THC when people inhale them together.

  Recruiting Phase 1/2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06099379

• How marijuana (THC) and tobacco interact when used together

  This test tries to see if combining marijuana (THC) and tobacco changes blood drug levels and how people feel and respond physically in adults who regularly use both.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05999383

• Using cannabis oil to support opioid addiction treatment

  This study is trying out a balanced cannabis oil to see if it can help people with opioid addiction who are also getting treatment with methadone.

  Recruiting Phase 2 BC Centre on Substance Use · Vancouver, British Columbia · NCT05985850

• Effects of cannabis on the microbiome and inflammation in HIV

  This study is testing how cannabis compounds THC and CBD affect gut health and inflammation in people living with HIV.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT05514899

• Transcranial Magnetic Stimulation to Help Heavy Cannabis Users See if They Use Less

  This study tests whether a non-invasive brain stimulation method called iTBS can help heavy cannabis users reduce their use by changing brain responses to cannabis cues.

  Recruiting Duke University · Durham, North Carolina · NCT05401929

• Examining how cannabis affects alcohol consumption

  This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.

  Recruiting Phase 2 Brown University · Providence, Rhode Island · NCT05389930

• Using cannabis extract to relieve acute radicular pain and reduce painkiller needs

  This study is testing if cannabis oil can help hospitalized patients with severe pain feel better and use fewer painkillers like morphine.

  Recruiting Phase 3 Hadassah Medical Organization · Jerusalem · NCT04816994

• Examining how chronic marijuana use affects inflammation and brain injury in HIV patients

  This study is testing how long-term marijuana use affects inflammation and brain health in people living with HIV.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04810858

• Examining how THC affects men and women differently

  This study is testing how vaporized THC affects men and women differently to see if their reactions vary based on gender.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT04704271

• Effects of cannabis on driving in young versus middle-aged users

  This study tests how smoking cannabis affects the driving skills of young and middle-aged people by comparing their performance in a driving simulator.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT04325958

• Examining how gender affects the immediate effects of THC in healthy individuals

  This study is testing how a synthetic form of THC affects healthy men and women differently to see if gender plays a role in its effects.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT02811510

• Examining how THC affects men and women differently

  This study tests how THC affects men and women differently to better understand its immediate effects on healthy individuals.

  Recruiting Phase 1 Yale University · West Haven, Connecticut · NCT02781519

NIH-funded research (newest 40 of 394)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hemp-derived CBD for reducing cannabis use in high-THC concentrate users

  A randomized, placebo-controlled trial tests whether hemp-derived CBD can help adults who mainly use high-potency cannabis concentrates reduce their cannabis use.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11567759

• Understanding how minority stress affects cannabis use in sexual minorities

  A research project follows young adult sexual minorities to see how daily stress and coping help explain cannabis use and related problems.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11544966

• Repeated cannabis with different THC/CBD mixes and how it affects pain, cravings, and body chemicals

  This project studies how taking cannabis repeatedly, with different THC and CBD amounts, changes pain experiences, potential for abuse, and levels of body chemicals related to the endocannabinoid system in adults.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11540788

• Terminal cannabinoid CB1 receptor changes in schizophrenia and cannabis use

  This grant studies how cannabis use and schizophrenia together affect a brain receptor (CB1) and what that could mean for memory and symptoms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11520628

• Cannabis policies and prenatal cannabis use: how laws affect moms and babies

  This grant studies how changes in recreational cannabis laws influence cannabis use during pregnancy and health outcomes for mothers and children.

  NIH research Boston College · Chestnut Hill, United States · NIH-11459463

• Youth and social media marketing of hemp-derived cannabis products

  Young people are increasingly exposed to hemp-derived cannabis product marketing on social media, and this study looks at how that marketing might influence their attitudes and curiosity.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11454966

• Genetic, Social, and Environmental Factors Shaping Early Cannabis Use in Youth

  A study with young people will look at how genes, surroundings, and behavior come together to predict who might start using cannabis early and how to prevent it.

  NIH research Baylor University · Waco, United States · NIH-11453679

• Cannabis use and how young adults feel about its effects

  This grant helps a researcher study how young adults experience cannabis, including both positive and negative effects, and how these feelings relate to use patterns.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11451475

• Perinatal drinking and cannabis use patterns across pregnancy and postpartum

  This project looks at how drinking and cannabis use change before, during, and after pregnancy to understand risks for moms and babies.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11447800

• Alcohol and cannabis use and helping in sexual violence situations

  A bystander-focused study explores how alcohol and cannabis by those nearby affect whether a person will step in during sexual violence events.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11446517

• Varenicline for Cannabis Use Disorder in Men and Women

  A clinical trial will test if varenicline helps people with cannabis use disorder, with a focus on differences between men and women and added counseling to support craving and mood management.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11445421

• Neural and computational markers linked to reward that may predict cannabis use escalation in young adults with anhedonia

  This study follows young adults with anhedonia to see how their brain responses to rewards and computational signals relate to increasing cannabis use over time.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11432812

• A blended online and text-message program to stop early alcohol and cannabis use among first-year college students

  A short, friendly program delivered online and by text messages aims to prevent teens in their first year of college from starting or increasing drinking and cannabis use.

  NIH research University of Texas Arlington · Arlington, United States · NIH-11429427

• Medical cannabis use in breast cancer patients during and after treatment

  Breast cancer patients who use medical cannabis during or after treatment are being studied to see how it affects their symptoms and overall outcomes.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11420589

• Cannabis Use Disorder and Opioid Health Risks in Veterans: A Long-Term VA Study

  A long-term study of veterans looking at how cannabis use disorder and its treatment relate to opioid-related health problems and hospital visits.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415661

• Partnering with pregnant people to create a new plan to cut tobacco and cannabis use

  A community-driven project with pregnant and postpartum women to design a tailored approach for reducing tobacco and cannabis use during and after pregnancy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11412943

• Cannabis use and its benefits and risks for cancer patients in community clinics

  This project follows cancer patients in community clinics to understand how cannabis use relates to symptoms, treatments, and safety.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11411363

• Reducing cannabis use to improve daily functioning

  Reducing cannabis use may improve everyday functioning and quality of life for adults with cannabis use disorders.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11408819

• A Digital Therapy to Help Adults Cut Heavy Cannabis Use

  A digital treatment delivered via a mobile app aims to help adults with cannabis use disorder reduce heavy cannabis use and stay engaged with self-managed wellness.

  NIH research Mobile Health Interventions LLC · Hastings on Hudson, United States · NIH-11408338

• Cannabis and aging-related brain changes in people living with HIV

  This study looks at brain tissue after death to understand how cannabis use may affect Alzheimer’s-related brain changes in people living with HIV as they age.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11407813

• Cannabis and the endocannabinoid system in OA pain and recovery after knee replacement

  This grant explores how cannabis use and the body’s endocannabinoid system influence inflammatory knee pain before and after knee replacement surgery, with hopes of guiding better pain treatment.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11406070

• Heavy cannabis use, brain function, and PrEP care for young people at risk for HIV

  A two-phase study will look at how heavy cannabis use affects brain function and how that relates to HIV prevention and PrEP engagement among young people in Chicago.

  NIH research University of Chicago · Chicago, United States · NIH-11405057

• Sex differences in how cannabis affects memory and brain health in older adults

  This study looks at whether older men and women who regularly use cannabis experience different effects on memory and risk factors for Alzheimer's disease.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404808

• Postpartum cannabis use and stress: how they’re linked

  This project studies how stress and hormones around birth may influence whether women return to using cannabis after pregnancy.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404799

• Sex differences in how cannabis use and stress affect the brain in young adults

  A study focused on young adults explores how cannabis use and stress interact differently for men and women and what this means for brain development and coping.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11404795

• How heavy cannabis use affects thinking and HIV prevention in young Black sexual minority men

  This project looks at whether heavy cannabis use changes thinking and decision-making and how that affects taking HIV prevention medicine (PrEP) among young Black sexual minority men.

  NIH research University of Chicago · Chicago, United States · NIH-11402104

• ADHD in adults, cannabis use, and related consequences

  This NIH grant explores how ADHD in adults relates to cannabis use and its consequences, with a focus on sex differences and real-world impact.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11400420

• Wearables and real-time prompts to understand how cannabis relates to depression

  A young adults study uses wearable devices and daily mood checks to explore how cannabis use and sleep affect depression.

  NIH research Brown University · Providence, United States · NIH-11400089

• Pregnenolone as a treatment for cannabis intoxication

  A small study will test whether pregnenolone can quickly lessen cannabis intoxication symptoms in adults in a safe, controlled setting.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11399979

• One-session computerized program with text reminders to help manage distress and reduce cannabis use

  A short computer-delivered emotional skills session plus just-in-time text reminders to help people who use cannabis and struggle with handling distress learn to tolerate emotions and cut back on use.

  NIH research Florida State University · Tallahassee, United States · NIH-11399242

• Brief parent guide to reduce college students’ drinking and cannabis use

  A short, parent-focused program helps college students cut back on drinking and cannabis use.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11398286

• Cannabis use and immunotherapy for cancer patients: long-term effects

  We’re studying how cannabis use affects people with cancer who are receiving immune-based treatments over a year.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11397515

• Caffeine and cannabis use and their effects on thinking skills in teens and young adults

  This grant studies how caffeine and cannabis together affect thinking and memory in adolescents and young adults who use both substances.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11395626

• CB1 receptor changes in schizophrenia and cannabis use linked to memory problems

  This grant studies how the brain’s cannabinoid system may work differently in people with schizophrenia who use cannabis, especially affecting memory and thinking.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11395592

• Understanding how cannabis use and genes change the brain to increase depression risk

  A research project at Yale is exploring how cannabis use might change specific brain cells and genes, potentially making people more vulnerable to depression.

  NIH research Yale University · New Haven, United States · NIH-11395269

• Cell-type epigenomic study to find drug targets for people with HIV who use cannabis

  A study in people with HIV who use cannabis aims to map how cannabis changes DNA regulation in specific immune cells to find druggable genes that could help HIV treatment.

  NIH research Yale University · New Haven, United States · NIH-11392878

• Epigenetics and cannabis effects on HIV brain inflammation

  This grant tests whether cannabinoids like THC and CBD can reprogram brain immune cells to reduce neuroinflammation in people living with HIV.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11392673

• Advancing Pregnenolone as a Therapy for Cannabis Use Disorder with Depression

  A study tests pregnenolone as a therapy for adults who have both cannabis use disorder and depression and aims to reduce cannabis use and improve mood.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11392064

• Cannabis and tobacco co-use in young adults during quit attempts

  Young adults who use both cannabis and nicotine may have a harder time quitting either one, and this study aims to understand how cannabis affects nicotine cessation.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11391210

• How heavy cannabis use may affect thinking and use of PrEP in young people

  This project looks at whether heavy cannabis use changes young people's thinking, sexual behavior, and whether they start and stay on PrEP.

  NIH research University of Chicago · Chicago, United States · NIH-11390927

Related topics

Quick answers

How many Cannabis clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (11 trials), Canada (3 trials), Netherlands (2 trials), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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