Cannabis use and IV sedation during wisdom tooth removal
Official title: Impact of Cannabis Use During Third Molar Surgery
Run by University of Michigan · NCT07423195 · Data updated 2026-11-12
This project will see if people who use cannabis need different IV sedative doses or have different vital signs and breathing during wisdom tooth removal compared with people who don't use cannabis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years to 99 Years |
| Sex | All |
| Enrollment | 242 (estimated) |
| Sponsor | University of Michigan Academic / other |
| Locations | 1 site (Ann Arbor, Michigan) |
| Status | Recruiting |
| Started | January 14, 2026 |
| Main results expected | January 2029 |
| Study ends | January 2030 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT07423195 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are generally healthy individuals age 16 or older (ASA I–II) scheduled for removal of at least one mandibular third molar who either regularly use cannabis or report no cannabis use.
✕Probably not a fit
Patients who are pregnant or lactating, have BMI ≥40, significant cardiovascular disease, third-molar pathology, or other conditions that increase surgical risk are excluded and unlikely to benefit directly from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares people who report recreational cannabis use to people who report no use while they receive IV sedation for removal of mandibular third molars. Researchers will record sedative doses, heart rate, blood pressure, and respiratory rate during the procedure and collect preoperative questionnaires. For self-reported users, a small hair or fingernail sample (and optionally extracted teeth) will be tested for cannabinoids, while non-users will provide a urine screen before surgery. All data and deidentified samples will be collected and analyzed through the University of Michigan Oral and Maxillofacial Surgery clinic.
Why it matters
Potential benefit: If successful, findings could help dentists and anesthesiologists personalize IV sedation and monitoring for patients who use cannabis to improve safety and comfort.
How similar studies have gone: Prior small studies and case reports suggest cannabis use can affect anesthetic requirements and respiratory responses, but larger, well-controlled observational data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Provide a signed and dated informed consent form. * Willing to comply with all study procedures and be available for the duration of the study. * Aged ≥ 16 years old. * Presence at least one mandibular 3rd molar * American Society of Anesthesiologists (ASA) physical status class I or II Exclusion Criteria: * Pathology (cyst or tumor) associated with the third molar tooth; * Health comorbidities (BMI 40 and above, and severe cardiovascular disease); * Pregnancy or lactation * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.
Where it's running
-
University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery
Ann Arbor, Michigan, United States Recruiting
Study contacts
- Principal investigator: Paulo zupelari Gonclaves, DDS, MS, PhD — University of Michigan School of Dentistry/Oral and Maxillofacial Surgery/Hospital Dentistry
- Study coordinator: Jennifer A Lay-Luskin, MPhil, CCRC
- Email: jalay@umich.edu
- Phone: Oral and Maxillofacial Surgery
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.