Long-term effects of cannabis smoking on lung health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This longitudinal study investigates the long-term health impacts of cannabis smoking on the lungs over a period of three years. Participants aged 18 to 85 with a history of cannabis smoking will undergo various assessments, including hyperpolarized xenon-129 MRI, pulmonary function tests, and questionnaires. The study aims to measure changes in lung function and health through regular visits and advanced imaging techniques. Data collected will help understand the effects of cannabis on lung health and inform future health guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature
* Provision of written, informed consent prior to any study specific procedures
* Males and females aged 18-85
* Current or former cannabis smoker (medicinal or recreational) with or without concurrent tobacco smoking history
* Participant is able to perform reproducible pulmonary function testing (i.e. the 3 best acceptable spirograms have Forced Expiratory Volume in 1 second (FEV1) values that do not vary more than 150 millilitres)
* Participant is able to perform a breathhold for 16s
* FEV1 \> 25% predicted
* Forced Vital Capacity (FVC) \> 25% predicted and \>0.5 litres

Exclusion Criteria:

* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material
* Participant is medically unstable in the opinion of the Principal Investigator
* Participant has a daytime room air oxygen saturation \<90% while lying supine
* Participant is unable to perform spirometry or plethysmography maneuvers
* Patient is pregnant at time of enrolment
* In the opinion of the investigator, patient suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia
* Patient has implanted mechanically, electrically or magnetically activated device or any metal in their body, which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) - at the discretion of the MRI Technologist.

Where it's running

• Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
  London, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Grace E Parraga, PhD — Robarts Research Institute, The University of Western Ontario
• Study coordinator: Grace E Parraga, PhD
• Email: gparraga@uwo.ca
• Phone: 519-931-5265

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Brain imaging to predict teens' response to cannabis treatment

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• Cannabis use and IV sedation during wisdom tooth removal

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• How marijuana (THC) and tobacco interact when used together

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  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05999383

• vEAET-H: a virtual group emotional therapy for chronic pain patients using medical cannabis in Israel

  This study tests a Hebrew, virtual, group-based emotional therapy to see if it can help reduce pain and improve emotional well-being in Israeli adults with chronic musculoskeletal pain who use medical cannabis.

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• Testing warning labels on cannabis packaging to see what design helps people notice risks

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  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07701304

• Mobile app to help adults in Quebec use cannabis more safely

  A mobile app is being tested to see if it helps adults who use cannabis non-medically in Quebec use cannabis more safely.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07524985

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.