SV2A in Older Adults
Official title: Effect of Cannabis Use on Synaptic Density in Older Adults
Run by Yale University · NCT05465538 · Data updated 2026-11-12
This study is testing if a certain brain protein in older adults can help us understand memory and thinking changes as they age.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Yale University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (New Haven, Connecticut) |
| Status | Recruiting |
| Started | July 6, 2022 |
| Main results expected | December 30, 2026 |
| Study ends | September 30, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT05465538 on ClinicalTrials.gov |
Is this trial a fit for you?
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✕Probably not a fit
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A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
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Why it matters
Potential benefit: Unknown
How similar studies have gone: Unknown
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to provide informed consent * Male or female, aged ≥50 years * No history of significant medical or neurological disease * BMI ≤ 50 * If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans Exclusion Criteria: * Women with a positive pregnancy test or women who are lactating * Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits; * History of a bleeding disorder or are currently taking anticoagulants * Subjects who have donated blood within 8 weeks of the present study
Where it's running
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Conneticut Mental Health Center
New Haven, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Deepak C D'Souza, MBBS, MD — Yale University
- Study coordinator: Khaled Draghmeh, MD
- Email: khaled.draghmeh@yale.edu
- Phone: 203-932-5711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.