SV2A in Older Adults

Effect of Cannabis Use on Synaptic Density in Older Adults

This study is testing if a certain brain protein in older adults can help us understand memory and thinking changes as they age.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 50 Years and up
• Sex: All
• Sponsor: Yale University (Academic / other)
• Drugs / interventions: radiation
• Locations: 1 site (New Haven, Connecticut)
• Trial ID: NCT05465538 on ClinicalTrials.gov

What this trial studies

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Who should consider this trial

Good fit: Unknown

Not a fit: Unknown

Why it matters

Potential benefit: Unknown

How similar studies have performed: Unknown

Eligibility criteria

Inclusion Criteria:

* Able to provide informed consent
* Male or female, aged ≥50 years
* No history of significant medical or neurological disease
* BMI ≤ 50
* If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Exclusion Criteria:

* Women with a positive pregnancy test or women who are lactating
* Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
* History of a bleeding disorder or are currently taking anticoagulants
* Subjects who have donated blood within 8 weeks of the present study

Where this trial is running

New Haven, Connecticut

• Conneticut Mental Health Center — New Haven, Connecticut, United States (Recruiting)

Study contacts

• Principal investigator: Deepak C D'Souza, MBBS, MD — Yale University
• Study coordinator: Angerlyk Frytz, MD

Conditions Cannabis Use