Clinical trial Recruiting at 1 site Phase1; Phase2 Interventional Ages 50 and up

SV2A in Older Adults

Official title: Effect of Cannabis Use on Synaptic Density in Older Adults

Run by Yale University · NCT05465538 · Data updated 2026-11-12

This study is testing if a certain brain protein in older adults can help us understand memory and thinking changes as they age.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages50 Years and up
SexAll
Enrollment24 (estimated)
SponsorYale University
Academic / other
Drugs / interventionsradiation
Locations1 site (New Haven, Connecticut)
StatusRecruiting
StartedJuly 6, 2022
Main results expectedDecember 30, 2026
Study endsSeptember 30, 2027
Registry record updatedOctober 20, 2026
Trial IDNCT05465538 on ClinicalTrials.gov

Is this trial a fit for you?

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Probably not a fit

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A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

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Why it matters

Potential benefit: Unknown

How similar studies have gone: Unknown

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Able to provide informed consent
* Male or female, aged ≥50 years
* No history of significant medical or neurological disease
* BMI ≤ 50
* If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Exclusion Criteria:

* Women with a positive pregnancy test or women who are lactating
* Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
* History of a bleeding disorder or are currently taking anticoagulants
* Subjects who have donated blood within 8 weeks of the present study

Where it's running

  • Conneticut Mental Health Center
    New Haven, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.