Mapping brain networks and blood flow for brain tumor surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop and validate a comprehensive fMRI software solution that integrates resting-state fMRI (rs-fMRI) and cerebrovascular reactivity (CVR) mapping to assist in the presurgical planning of brain tumor resections. The study will compare the effectiveness of rs-fMRI against traditional task-based fMRI using intra-operative direct cortical stimulation as a benchmark. Additionally, the research will optimize the software for clinical use and assess its feasibility in mapping critical functional networks in the brain. The collaboration with NordicNeuroLab will enhance the software's development, ensuring it meets clinical standards.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. patient must be \>/= 18 years of age;
2. patients who will undergo neurosurgical resection of brain tumors;
3. patients who will undergo presurgical fMRI as standard of care;
4. patients who on neurosurgical evaluation will undergo direct cortical stimulation (DCS) as standard of care.

For the retrospective study, we will review up to 1600 patients all clinical presurgical fMRI studies performed on brain tumor patients at the MD Anderson since 5/2004.

The inclusion criteria:

1. patients must be \>/= 18 years of age;
2. patients who had the presurgical fMRI that contained at least one task-based fMRI scan.

Exclusion Criteria:

Exclusion criteria for the prospective study:

1. patients cannot give informed consent;
2. patients cannot undergo MRI examinations;
3. patients who are indicated for speech fMRI only but cannot comply with any of the speech tasks based on the evaluation of a clinical neuropsychologist.

Exclusion criteria for the retrospective study:

1. all fMRI scans were contaminated by head motions (translation \> 2 mm or rotation \> 2 degrees);
2. only speech fMRI paradigms were performed, and patients were not able to comply with any of the speech tasks based on the evaluation of a clinical neuropsychologist.

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Ho-Ling Liu, PhD — M.D. Anderson Cancer Center
• Study coordinator: Ho-Ling Liu, PhD
• Email: hlaliu@mdanderson.org
• Phone: (713) 563-7383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.