Non-invasive imaging to characterize gliomas
Pilot Study for Non-invasive Glioma Characterization Through Molecular Imaging
This study is testing a new MRI method to see if it can help understand gliomas better by measuring certain substances in the tumor without needing any invasive procedures.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Miami Academic / other |
| Locations | 1 site (Miami, Florida) |
| Trial ID | NCT03684109 on ClinicalTrials.gov |
What this trial studies
This pilot study focuses on developing and optimizing MRI-based sequences to non-invasively quantify the distribution of 2-hydroxyglutarate (2HG) and tumor cellularity in gliomas. By using a 3T MRI scanner, the study aims to enhance the understanding of glioma biology and potentially guide the development of new therapies. The approach seeks to provide critical insights without the need for invasive procedures, thereby improving patient care.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with suspected or confirmed gliomas who are scheduled for a medically indicated biopsy or resection.
Not a fit: Patients who are unable to consent, minors, pregnant women, or those who cannot undergo MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients with gliomas.
How similar studies have performed: While the approach of using MRI for glioma characterization is established, this specific methodology focusing on 2HG distribution is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 year old) * Subjects with suspected or confirmed gliomas and who will have a medically indicated biopsy or resection of his/her brain lesion. Exclusion Criteria: * Adults unable to consent * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Patients unable to have MRI done
Where this trial is running
Miami, Florida
- University of Miami — Miami, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Macarena De La Fuente, MD — University of Miami
- Study coordinator: Nathalie Padron
- Email: npadron@med.miami.edu
- Phone: 305-243-3530
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.