Mask-free brain radiotherapy using surface-guided imaging
Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients
We will try using surface imaging so adults receiving fractionated radiotherapy for brain tumors can be treated without the usual thermoplastic mask, with the beam paused if they move.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Drugs / interventions | Radiation |
| Locations | 1 site (Woluwe-Saint-Lambert, Brussels Capital) |
| Trial ID | NCT07323966 on ClinicalTrials.gov |
What this trial studies
This interventional feasibility study tests whether surface-guided radiation therapy (SGRT) can replace thermoplastic immobilization masks for adults undergoing fractionated radiotherapy for brain tumors. Participants take part in a simulated mask-free session while cameras track their surface position in real time and the radiation beam is set to interrupt if motion exceeds preset thresholds. Investigators will measure positional stability without a mask and collect patient-reported comfort and anxiety data using questionnaires completed in French. The results will inform whether mask-free delivery is technically feasible and acceptable to patients and guide further clinical testing.
Who should consider this trial
Good fit: Ideal candidates are adults (≥18 years) with a brain tumor scheduled for fractionated radiotherapy who can remain still during sessions and can read and complete questionnaires in French.
Not a fit: Patients who cannot stay still, who are not adults, or who cannot complete questionnaires in French are unlikely to benefit from this mask-free approach.
Why it matters
Potential benefit: If successful, this could reduce discomfort and anxiety from mask immobilization while maintaining precise beam delivery through real-time motion monitoring.
How similar studies have performed: Surface guidance has been used successfully for positioning in other radiotherapy sites, but very few studies have tested mask-free brain radiotherapy specifically.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years old * Brain tumor treated with fractionated radiotherapy * Able to read and complete a questionnaire in French Exclusion Criteria: * Inability to remain still
Where this trial is running
Woluwe-Saint-Lambert, Brussels Capital
- Cliniques Universitaires Saint-Luc — Woluwe-Saint-Lambert, Brussels Capital, Belgium (Recruiting)
Study contacts
- Study coordinator: Dario Di Perri
- Email: dario.diperri@saintluc.uclouvain.be
- Phone: +32 2 764 47 52
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.