Mask-free brain radiotherapy using surface-guided imaging
Official title: Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients
Run by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT07323966 · Data updated 2026-11-12
We will try using surface imaging so adults receiving fractionated radiotherapy for brain tumors can be treated without the usual thermoplastic mask, with the beam paused if they move.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Drugs / interventions | Radiation |
| Locations | 1 site (Woluwe-Saint-Lambert, Brussels Capital) |
| Status | Recruiting |
| Started | November 18, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | January 7, 2026 |
| Trial ID | NCT07323966 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18 years) with a brain tumor scheduled for fractionated radiotherapy who can remain still during sessions and can read and complete questionnaires in French.
✕Probably not a fit
Patients who cannot stay still, who are not adults, or who cannot complete questionnaires in French are unlikely to benefit from this mask-free approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional feasibility study tests whether surface-guided radiation therapy (SGRT) can replace thermoplastic immobilization masks for adults undergoing fractionated radiotherapy for brain tumors. Participants take part in a simulated mask-free session while cameras track their surface position in real time and the radiation beam is set to interrupt if motion exceeds preset thresholds. Investigators will measure positional stability without a mask and collect patient-reported comfort and anxiety data using questionnaires completed in French. The results will inform whether mask-free delivery is technically feasible and acceptable to patients and guide further clinical testing.
Why it matters
Potential benefit: If successful, this could reduce discomfort and anxiety from mask immobilization while maintaining precise beam delivery through real-time motion monitoring.
How similar studies have gone: Surface guidance has been used successfully for positioning in other radiotherapy sites, but very few studies have tested mask-free brain radiotherapy specifically.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years old * Brain tumor treated with fractionated radiotherapy * Able to read and complete a questionnaire in French Exclusion Criteria: * Inability to remain still
Where it's running
-
Cliniques Universitaires Saint-Luc
Woluwe-Saint-Lambert, Brussels Capital, Belgium Recruiting
Study contacts
- Study coordinator: Dario Di Perri
- Email: dario.diperri@saintluc.uclouvain.be
- Phone: +32 2 764 47 52
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.