Using advanced microscopy to study brain tissue and improve treatment for brain diseases
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cerebral Organoids and Surgically Dissected Human Live Brains
NA · National Taiwan University Hospital · NCT05921786
This study is testing new ways to use brain tissue samples to improve treatments for brain diseases like tumors and help doctors plan better surgeries.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | National Taiwan University Hospital (other) |
| Drugs / interventions | radiation, chemotherapy, immunotherapy |
| Locations | 1 site (Taipei) |
| Trial ID | NCT05921786 on ClinicalTrials.gov |
What this trial studies
This research aims to create a comprehensive database of various brain tissues to validate the use of human brain tissue models and human-induced pluripotent stem cells (hiPSCs)-derived organoid models. It focuses on brain diseases, particularly brain tumors, where obtaining functional brain tissue samples is challenging. The study will utilize an electrophysiological system and a multiphoton microscope to gather detailed information about brain diseases before surgical interventions. This approach seeks to enhance the accuracy of surgical resection strategies and improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old diagnosed with brain diseases who are suitable and willing to undergo resection surgery.
Not a fit: Patients who cannot provide consent, those with inconclusive tumor samples, or those undergoing biopsy surgery instead of resection will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more precise surgical strategies and improved treatment outcomes for patients with brain diseases.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for brain surgery, indicating potential success for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Patients older than the age of 18 with diagnosis of brain disease (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery. Exclusion Criteria: 1. Patients who cannot give consent to participate in the study. 2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow. 3. Patients who only receives biopsy surgery rather than resection surgery. 4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.
Where this trial is running
Taipei
- Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University — Taipei, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Kuo-Chuan Wang
- Email: wang081466@yahoo.com.tw
- Phone: +886-23123456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Brain Diseases, Brain Tumor, brain diseases, brain tumor