Non-invasive methods for diagnosing and monitoring brain tumors
Official title: Non-invasive Brain Tumor Diagnosis Through Analysis of Proximal Fluids, Circulating Tumor Cells, and Biomolecules
Run by The Institute of Molecular and Translational Medicine, Czech Republic · NCT06501521 · Data updated 2026-11-12
This study is testing new blood and urine tests to see if they can help doctors better diagnose and monitor brain tumors in patients with glioblastoma.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | The Institute of Molecular and Translational Medicine, Czech Republic Academic / other |
| Locations | 1 site (Olomouc) |
| Status | Recruiting |
| Started | January 1, 2020 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2030 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT06501521 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients diagnosed with glioblastoma.
✕Probably not a fit
Patients with other types of cancer or inflammatory diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients with glioblastoma (GBM) and aims to conduct repeated assessments before and three months after surgery. It will analyze circulating tumor cells and the transcriptomic profiles of extracellular vesicles (EVs) in the blood to evaluate their prognostic significance. Additionally, the study will investigate proteomic profiles in blood and ocular secretions from various patient groups to identify novel protein biomarkers. An innovative approach will also be employed to monitor GBM patients by detecting specific nucleic acid fragments in urine.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for diagnosing and monitoring brain tumors, enhancing treatment efficacy and patient outcomes.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in using non-invasive biomarkers for cancer monitoring.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients with brain tumors - Exclusion Criteria: No other cancer; no inflammatory disease \-
Where it's running
-
Department of Neurosurgery, University Hospital Olomouc
Olomouc, Czechia Recruiting
Study contacts
- Principal investigator: Marian Hajduch, MD,PhD — Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
- Study coordinator: Josef Srovnal, MD,PhD
- Email: josef.srovnal@upol.cz
- Phone: +420585632137
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.