Optimizing PET Imaging with 18F-DOPA for Various Conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase III interventional study focuses on optimizing 18F-DOPA PET/CT imaging for patients with congenital hyperinsulinism, neuroblastoma, neuroendocrine tumors, Parkinson's disease, and Lewy body dementia. The study will evaluate the imaging capabilities of 18F-DOPA, a tracer that mimics L-DOPA, to provide valuable insights into these conditions. It will involve both pediatric and adult patients, assessing the tracer's safety and efficacy in a local setting using advanced imaging technology. The primary objective is to enhance image quality, while secondary objectives include analyzing gallbladder activity patterns.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism.
2. Pediatric patients (less than 18 years old) with neuroblastoma.
3. Pediatric (less than 18 years old) or Adult patients (18 or older) with known or clinically suspected neuroendocrine tumor.
4. Adult patients (18 or older) with a clinical suspicion of Parkinson's disease or Lewy body dementia.
5. Pediatric (less than 18 years old) or Adult patients (18 or older) with brain tumors.

Exclusion Criteria:

1. Unable to obtain consent
2. Weight \>225 kg (weight limitation of PET/CT scanner)
3. Adult patients unable to lie flat for 20-30 minutes to complete the PET-CT session.
4. Young pediatric patients (less than 13 years old) who are unable to lie flat for 20-30 minutes and for whom clinical sedation is contraindicated (as determined by a pediatric anaesthesiologist).
5. Lack of intravenous access
6. History of previous cholecystectomy (excluded from dynamic abdomen sub-study only)
7. Pregnancy

Where it's running

• WC Mackenzie Health Science Centre / University of Alberta Hospital
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Jonathan Abele, MD — University of Alberta
• Study coordinator: Jonathan Abele, MD
• Email: jabele@ualberta.ca
• Phone: 1-780-407-6907

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.