Imaging and Genomic Signs of Brain Tumors to Help Manage Care
Official title: Imaging and Genomic Signatures of Brain Tumor Heterogeneity and Evolution to Optimize Patient Management
Funded at University of California, San Francisco · NIH-11413758 · Data updated 2026-11-12
This project studies brain tumors in adults to find imaging and DNA clues that reflect tumor differences and how they change, with the goal of guiding better treatment decisions for glioblastoma and meningioma.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2007 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,654,906 |
| NIH project number | 5P01CA118816-18 |
| Project ID | NIH-11413758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with glioblastoma or meningioma who are undergoing standard management and follow-up.
✕Less likely to help
Patients without brain tumors or those not receiving imaging-guided care would not directly benefit.
What this research studies
Researchers at UCSF are linking advanced brain imaging with genomic information to understand how glioblastoma and meningioma tumors vary within a patient and evolve over time. The work builds on new metabolic imaging techniques and DNA methylation findings to identify imaging markers that reflect underlying biology and treatment response. By connecting non-invasive imaging signals to genomic drivers, the study aims to speed the identification of effective therapies and improve patient management. Projects 1-4 will translate these insights into imaging metrics that can monitor early treatment effects and guide clinical decisions.
Why it matters
Potential benefit: If successful, patients could receive more personalized and timely treatment plans based on imaging that mirrors the tumor’s biology and response to therapy.
How similar studies have gone: Previous work has shown that imaging and genomic data can reveal tumor behavior and treatment response, but this renewal aims to integrate and translate these signals more directly into clinical decision-making.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Chang, Susan M — University of California, San Francisco
- Study coordinator: Chang, Susan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.