Using advanced imaging to improve brain tumor surgery

Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling

This study is testing a new imaging technique during brain tumor surgery to see if it helps doctors better understand the tumor type and grade, which could lead to better treatment results for patients.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 20 Years and up
• Sex: All
• Sponsor: National Taiwan University Hospital (other)
• Drugs / interventions: radiation
• Locations: 1 site (Taipei)
• Trial ID: NCT05943262 on ClinicalTrials.gov

What this trial studies

This research focuses on developing a new pathological technology that utilizes rapid whole-mount tissue staining and high-resolution nonlinear optical microscopy to assess brain tumors during surgery. The goal is to accurately determine the grade and type of brain tumors, which is crucial for planning effective surgical strategies. By comparing images obtained from this novel imaging technique with standard pathological workflows, the study aims to enhance the precision of tumor classification and grading in real-time. This could lead to improved surgical outcomes for patients with brain tumors.

Who should consider this trial

Good fit: Ideal candidates include patients over 20 years old diagnosed with brain tumors who are suitable and willing to undergo resection surgery.

Not a fit: Patients who are unable to provide consent, only require biopsy surgery, or have tumors that cannot be conclusively diagnosed by standard methods may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance the accuracy of brain tumor surgeries, leading to better patient outcomes and survival rates.

How similar studies have performed: While there have been related studies, this specific approach utilizing nonlinear optical microscopy for intraoperative assessment is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

1\. Patients older than the age of 20 with diagnosis of brain tumor (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery.

Exclusion Criteria:

1. Patients who cannot give consent to participate in the study.
2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow.
3. Patients who only receives biopsy surgery rather than resection surgery.
4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.

Where this trial is running

Taipei

• Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University — Taipei, Taiwan (RECRUITING)

Study contacts

• Study coordinator: Kuo-Chuan Wang

Conditions: Brain Tumor, Brain Cancer, brain tumor, brain cancer