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Clinical trial Recruiting at 1 site Observational Ages 20 and up

Using advanced imaging to improve brain tumor surgery

Official title: Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling

Run by National Taiwan University Hospital · NCT05943262 · Data updated 2026-11-12

This study is testing a new imaging technique during brain tumor surgery to see if it helps doctors better understand the tumor type and grade, which could lead to better treatment results for patients.

Quick facts

Study typeObservational
Ages20 Years and up
SexAll
Enrollment100 (estimated)
SponsorNational Taiwan University Hospital
Academic / other
Drugs / interventionsradiation
Locations1 site (Taipei)
StatusRecruiting
StartedMay 1, 2023
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedAugust 21, 2024
Trial IDNCT05943262 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients over 20 years old diagnosed with brain tumors who are suitable and willing to undergo resection surgery.

Probably not a fit

Patients who are unable to provide consent, only require biopsy surgery, or have tumors that cannot be conclusively diagnosed by standard methods may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on developing a new pathological technology that utilizes rapid whole-mount tissue staining and high-resolution nonlinear optical microscopy to assess brain tumors during surgery. The goal is to accurately determine the grade and type of brain tumors, which is crucial for planning effective surgical strategies. By comparing images obtained from this novel imaging technique with standard pathological workflows, the study aims to enhance the precision of tumor classification and grading in real-time. This could lead to improved surgical outcomes for patients with brain tumors.

Why it matters

Potential benefit: If successful, this approach could significantly enhance the accuracy of brain tumor surgeries, leading to better patient outcomes and survival rates.

How similar studies have gone: While there have been related studies, this specific approach utilizing nonlinear optical microscopy for intraoperative assessment is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1\. Patients older than the age of 20 with diagnosis of brain tumor (both newly-diagnosed or recurrent) who are suitable and willing to receive resection surgery.

Exclusion Criteria:

1. Patients who cannot give consent to participate in the study.
2. The tumor samples failed to give a conclusive pathological diagnosis by standard pathological workflow.
3. Patients who only receives biopsy surgery rather than resection surgery.
4. Significant post-irradiation effect or radiation necrosis reported in the pathological examination.

Where it's running

  • Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University
    Taipei, Taiwan     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.