Sponsor or institution

Clinical trials and research at University of Oklahoma

• 65Clinical trials
• 59NIH research projects
• 2Countries

Newest trials

All recruiting trials (65)

• Biopsy-site marker stiffness in breast cancer

  This observational study will see if the stiffness of biopsy-site markers relates to inflammation and potential spread in women with breast cancer.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07833566

• Protoacoustic Imaging to See Radiation Delivery in Proton Therapy

  This study tests radioacoustic imaging with ultrasound to help doctors see where proton therapy is delivering radiation for liver and prostate cancer patients.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07832617

• Modified FOLFIRINOX with Pentamidine in Advanced Pancreatic Cancer

  This study tests whether adding pentamidine to a modified FOLFIRINOX regimen helps people with advanced or metastatic pancreatic cancer.

  Recruiting Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT07829185

• Testing Alcohol Health Warning Labels for US Adults

  A randomized online study will test different warning statements about alcohol and breast cancer risk among adult US women who drink or are young non-drinkers to see which warnings are most convincing.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07812545

• Testing warning labels on cannabis packaging to see what design helps people notice risks

  Researchers are testing different cannabis warning labels to see which designs make people notice health risks and think about their use more carefully.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07701304

• Using near-infrared light to help brain blood flow and thinking in people with mild cognitive impairment

  This trial tests whether daily 20-minute transcranial photobiomodulation with near-infrared light can improve brain blood flow regulation and memory in people with mild cognitive impairment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07651787

• Dietary fiber and sarcopenia risk in head and neck cancer

  This observational study will track fiber intake and related biological markers in adults with head and neck cancer from diagnosis for six months to see if higher fiber intake relates to better muscle health and lower inflammation during treatment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07622914

• Reset Challenge: See if 30 days without alcohol reduces high-risk drinking

  This 30-day mobile program tests whether people who drink heavily can cut back or stop drinking for a month, with a focus on those in Oklahoma.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07591428

• Acute Creatine Gummies vs. Powder in Healthy Adults

  This study tests whether Create Wellness creatine gummies raise blood creatine levels differently than creatine monohydrate powder in healthy adults after a single dose.

  Recruiting University of Oklahoma · Norman, Oklahoma · NCT07579455

• Empowered Relief pain-management class for cancer survivors

  This project will test whether a single 2-hour Zoom Empowered Relief class helps cancer survivors with chronic pain reduce pain and pain-related distress.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07578376

• Improving balance control in older adults

  This study will test 2 weeks of moving-platform balance training with either restricted or full vision in adults 65 and older to see if limiting vision helps them rely more on touch and body sense and improves balance when they start walking.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07554118

• Buzzy bee vibration and cold for easing pain and fear during elbow pin removal

  We will test whether the Buzzy vibrating ice-pack can reduce pain and fear for children ages 3 to 10 during elbow pin removal.

  Recruiting at 2 sites University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT07520851

• High-fiber mHealth program for young adults with prediabetes

  This three-month phone-based program tests whether weekly home-delivered high-fiber foods, brief education, and continuous glucose monitor feedback can improve blood sugar control in young adults (18–39) with prediabetes.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07491653

• Multi-channel program using a virtual tribal health educator to boost colorectal cancer screening for American Indian adults in Oklahoma.

  This project will try a virtual tribal community health educator delivered by social media and clinic text messages to see if it increases colorectal cancer screening among American Indian adults aged 45–75 in the IHS Clinton Service Unit.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07254910

• Warmed versus room-temperature contrast during hysterosalpingogram to reduce cramping and false tubal blockage

  This trial will test whether warming the contrast dye used during HSG reduces pain and the chance of a false proximal tubal blockage for women 18–45 having tubal testing for infertility.

  Recruiting Early Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT07226310

• Cemiplimab alone or with fianlimab after stereotactic body radiation for oligometastatic clear cell kidney cancer

  This trial will test whether giving cemiplimab alone or with fianlimab after stereotactic body radiation helps people with oligometastatic clear cell kidney cancer stay free of recurrence longer.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT07223541

• Oncology care coordination program for Native American patients

  This project will test whether a coordinated care and navigation program (C3PO) helps Native American adults newly diagnosed with cancer communicate with care teams and report better outcomes.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07217574

• Near-infrared light therapy to improve brain blood flow and thinking in young and older adults

  This pilot will test whether near-infrared light delivered to the head can improve brain blood-flow control (neurovascular coupling) and thinking skills in young and older adults.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07209683

• Meloxicam for pain after Mohs surgery

  This trial will try two doses of meloxicam plus acetaminophen versus acetaminophen with alternating ibuprofen to see which controls pain best for adults having Mohs skin cancer surgery.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT07200544

• ctDNA-guided therapy de-escalation for metastatic urothelial cancer

  This trial tests whether switching to pembrolizumab alone after 24 weeks of pembrolizumab plus enfortumab vedotin helps people with metastatic urothelial cancer who show a large drop in ctDNA.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT07183319

• How cigarillo flavor rules affect young adult cigarillo use (Project CLARITY)

  This study will test whether different cigarillo flavor types and additives make cigarillos more appealing and change smoking, switching, or quitting behavior in 18–24-year-olds who currently use cigarillos.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT07162935

• Varenicline with Nicotine Lozenges and a Smartphone App to Help You Stay on Track

  A 2x2 trial tests whether adding nicotine lozenges and a smartphone adherence app to varenicline helps people quit smoking more than varenicline alone.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT07099638

• Oklahoma Native American smoking cessation and pain risk IV

  This pilot will try 4 weeks of verified smoking abstinence with financial incentives to see if it lowers physiological signs of chronic pain risk in adult Native American daily smokers.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT07080788

• Connect2Care prostate cancer education and screening support for African American men

  This 30-day test will see if the Connect2Care app can improve prostate cancer knowledge and increase readiness to get a PSA test among African American men aged 45–69 in Oklahoma.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07055165

• Navigator-supported shorter-course radiation for breast and prostate cancer patients

  This project will see if offering patient navigators and culturally tailored surveys helps African American, Native American, and Hispanic/Latino patients with breast or prostate cancer finish their radiation treatment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07014618

• Effects of Semaglutide on Smoking and Health in Obese Adults

  This study is testing if a medication called semaglutide can help obese adults who smoke reduce their cravings and improve their health over 12 weeks.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT06986993

• Genomic profiling of prostate cancer in Native American men

  This project will test whether analyzing tumor and blood samples from men who identify as Native American can reveal genes that influence prostate cancer and treatment choices.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT06960798

• Cooperative Extension survivorship program for adults after cancer treatment

  This program tests a group-based survivorship curriculum delivered through Cooperative Extension to see if it helps adults who finished active cancer treatment improve quality of life and other health outcomes.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT06869512

• Smartphone intervention to reduce alcohol use among homeless adults

  This study is testing whether a smartphone app can help homeless adults reduce their alcohol use more effectively than standard treatment at shelters.

  Recruiting Phase 2/3 University of Oklahoma · Oklahoma City, Oklahoma · NCT06821295

• Empowering smoking cessation for LGBTQ+ adults in Oklahoma, Arkansas, and Texas

  This project will try adding online volunteer activities and a digital support hub to a quit-app plus mailed nicotine patches to see if it helps LGBTQ+ adults in Oklahoma, Arkansas, and Texas quit smoking.

  Recruiting Phase 2/3 University of Oklahoma · Oklahoma City, Oklahoma · NCT06820034

• Remote physical activity program for cancer survivors with and without diabetes

  This study is trying out a remote exercise program for cancer survivors, with and without diabetes, to see if it can help improve their quality of life and cognitive skills after chemotherapy.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT06725953

• Flavored cigarillos and young adults' smoking perceptions in real-world settings.

  This project will test whether different cigarillo flavors change taste, enjoyment, puffing behavior, and buying choices in young adults who use cigarillos.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT06668350

• Mobile health app to improve quality of life for Black prostate cancer survivors

  This study is testing a mobile health app designed for Black men with prostate cancer to see if it can help improve their quality of life during and after treatment.

  Recruiting at 3 sites University of Oklahoma · Tallahassee, Florida and 2 other locations · NCT06651359

• Non-invasive brain stimulation for improving memory after stroke

  This study is testing whether a type of non-invasive brain stimulation can help improve memory and brain function in people who have had a stroke.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT06516588

• Using antibiotics to reduce complications in obese pregnant women during labor induction

  This study is testing if giving antibiotics to obese pregnant women during labor induction can help lower the chances of needing a cesarean delivery and reduce infections after childbirth.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT06488781

• Financial incentives to help couples quit smoking

  This study tests if giving financial rewards can help couples who both smoke to quit together more successfully than those who don’t get rewards.

  Recruiting Phase 2 University of Oklahoma · Athens, Georgia and 1 other locations · NCT06296849

• One-year Parent-Child Assistance Program for parents with recent substance use

  This project will test whether a one-year Parent-Child Assistance Program helps parents who used substances during pregnancy stay with or reunify with their children and support their recovery.

  Recruiting at 2 sites University of Oklahoma · Enid, Oklahoma and 1 other locations · NCT06163651

• Early IV Magnesium for Moderate Asthma Attacks in Children

  This study tests if giving magnesium right away helps children aged 5-17 with moderate asthma attacks feel better and leave the emergency room faster.

  Recruiting Early Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT06137040

• Combining relugolix and enzalutamide for high-risk prostate cancer treatment

  This study is testing if combining two medications, relugolix and enzalutamide, can help men with high-risk prostate cancer do better with their treatment and live longer.

  Recruiting Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT06130995

• Topical CBD Patch for Healing a Forehead Scar

  Researchers will test whether CBD ointment with a silicone patch helps improve scar appearance on half of a paramedian forehead flap after surgery, compared with a silicone patch on the other half.

  Recruiting Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT06129591

• Comparing three medications for pain management in young children during minor procedures

  This study is testing three different nasal medications to see which one helps young children feel less pain and anxiety during minor procedures in the emergency room.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT05934669

• Improving heart function in cancer patients using vagus nerve stimulation

  This study is testing whether a small device that stimulates the vagus nerve can help improve heart function in cancer patients who have recently received chemotherapy.

  Recruiting at 2 sites Early Phase 1 University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT05921253

• Understanding pain risk in Native American adults related to stress and discrimination

  This study looks at how stress and discrimination affect chronic pain risk in Native American adults to see if there are ways to help reduce their pain.

  Recruiting University of Oklahoma · Tulsa, Oklahoma · NCT05723081

• Non-painful exercise program for patients with Peripheral Artery Disease

  This study is testing a new exercise program that doesn’t cause pain to see if it can help people with Peripheral Artery Disease walk better and improve their quality of life.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05712395

• Spine radiosurgery versus conventional radiation for spinal metastases

  This trial tests three radiation approaches—single‑fraction external beam radiation, single‑fraction SBRT, and two‑fraction higher‑dose SBRT—to see which best reduces pain for adults with cancer that has spread to the spine.

  Recruiting Phase 2 University of Oklahoma · Baltimore, Maryland and 1 other locations · NCT05617716

• Investigating the effects of propranolol and nicotine patches on smoking cues

  This study is testing whether taking propranolol and using nicotine patches can help daily smokers resist the urge to smoke when they see things that remind them of smoking.

  Recruiting Phase 4 University of Oklahoma · Tulsa, Oklahoma · NCT05587361

• Helping mothers with substance use issues during pregnancy

  This study is trying out a program to help mothers who have used drugs or alcohol during pregnancy get support and resources to build healthier lives for themselves and their children.

  Recruiting at 2 sites University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT05534568

• Testing a new drug combination for certain types of gynecological cancers

  This study is testing a new combination of two drugs to see if they can help people with certain types of gynecological cancers feel better and improve their treatment outcomes.

  Recruiting at 4 sites Phase 2 University of Oklahoma · Orlando, Florida and 3 other locations · NCT05512208

• Comparing digital and analog chest tube drainage systems in children

  This study is testing whether a new digital chest tube drainage system works better than the traditional one for kids who need chest tubes for lung issues.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05511987

• Effects of electrical stimulation on fatigue in healthy individuals

  This study tests if a mild electrical current applied to the neck can help healthy adults feel less tired and improve their muscle performance.

  Recruiting University of Oklahoma · Norman, Oklahoma · NCT05487131

• NAD supplementation to improve brain vascular health in older adults

  This study is testing if a vitamin called Nicotinamide Riboside can help improve brain health and memory in older adults by boosting a key molecule in the brain.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT05483465

• Mobile health technology to help people quit smoking in Laos

  This study is testing a mobile app designed to help people in Laos quit smoking by providing personalized support and resources.

  Recruiting at 2 sites Phase 2 University of Oklahoma · Champasak and 1 other locations · NCT05233228

• Neuromodulation to improve heart failure symptoms and function

  This study is testing whether a gentle electrical stimulation of the vagus nerve can help people with heart failure feel better and improve their ability to exercise over three months.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05230732

• A smartphone app designed to help African American smokers quit smoking

  This study is testing a smartphone app designed to help African American smokers quit smoking by providing support and rewards during their quit journey.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05188287

• Effect of Dapagliflozin on Atrial Fibrillation in Diabetic Patients

  This study is testing if the diabetes medication Dapagliflozin can help reduce the heart rhythm problems caused by atrial fibrillation in people with diabetes.

  Recruiting Phase 3 University of Oklahoma · Oklahoma City, Oklahoma · NCT05174052

• Blood test for tumor DNA in patients with pancreatic cancer

  This study is testing if a blood test for tumor DNA can help doctors understand how well treatment is working for people with pancreatic cancer.

  Recruiting at 2 sites University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT05052671

• Using ketamine to manage pain after hemorrhoid surgery

  This study is testing if using ketamine during hemorrhoid surgery can help reduce pain afterwards for patients with severe hemorrhoids.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT04248205

• Using nerve stimulation to manage inflammation in septic shock

  This study is testing if a new ear stimulation technique can help reduce inflammation and improve recovery in patients with septic shock.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03992378

• Exoskeleton-assisted gait training for stroke rehabilitation

  This study is testing whether using a robotic exoskeleton during walking therapy can help stroke survivors recover better than regular walking exercises.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03980457

• Effects of diet and exercise on patients with peripheral artery disease

  This study is testing whether a special diet and exercise program together can help people with peripheral artery disease walk better and feel healthier compared to just exercising at home.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03845036

• Imaging study to evaluate leukemia treatment response

  This study is testing if a special type of imaging can help doctors see how well treatments are working for people with high-risk acute leukemia or myeloma.

  Recruiting Phase 1 University of Oklahoma · Washington D.C., District of Columbia and 2 other locations · NCT03633955

• Identifying Biomarkers for Bone Marrow Cell Growth After Transplantation

  This study is testing if a special imaging technique can help doctors see how well bone marrow cells are growing after a stem cell transplant in patients at high risk for graft failure.

  Recruiting at 3 sites Phase 1 University of Oklahoma · Atlanta, Georgia and 3 other locations · NCT03541889

• Evaluating the impact of supervision on endoscopy training

  This study is testing how different levels of supervision during training affect how well gastroenterology fellows and general surgery residents learn to perform colonoscopies.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03495141

• Non-invasive stimulation of the tragus to reduce inflammation in heart failure patients

  This study is testing if a new way of stimulating a small nerve in the ear can help reduce inflammation and improve heart function in patients with severe heart failure.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT02898181

• Evaluating lung function improvement after bronchial thermoplasty in severe asthma patients

  This study looks at how bronchial thermoplasty affects lung function in people with severe asthma by checking their breathing tests before and after the treatment.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT02241265

NIH-funded research (newest 40 of 59)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Personalized 3D molds to shape breast reconstruction

  A doctor-relevant project is testing patient-specific 3D printed molds to guide breast reconstruction after mastectomy, aiming to improve body image and quality of life for feminine-presenting individuals.

  NIH research University of Oklahoma · Norman, United States · NIH-11604133

• Faster 3D/4D imaging to speed up testing of cancer drugs on tumor organoids

  This project builds a new, ultrafast label-free 4D imaging system with AI to watch how patient-like tumor organoids respond to cancer drugs, helping researchers find more promising treatments.

  NIH research University of Oklahoma · Norman, United States · NIH-11397215

• How our genes control skin color and pigmentation

  Scientists are studying how epigenetic and transcriptional controls shape human skin color and related pigmentation differences.

  NIH research University of Oklahoma · Norman, United States · NIH-11387799

• Nanomedicine delivery framework for skeletal muscle therapies

  A new framework aims to safely and efficiently deliver tiny nanoparticles carrying drugs or genetic payloads to skeletal muscle cells.

  NIH research University of Oklahoma · Norman, United States · NIH-11377518

• Atlas of bacterial drug entry and exit to help design better antibiotics

  Researchers are building smart computer models and chemical tests to understand how to get drugs into Gram-negative bacteria like Acinetobacter baumannii so new antibiotics can work.

  NIH research University of Oklahoma · Norman, United States · NIH-11376561

• Understanding protein forms in disease with advanced mass spectrometry

  A researchers team will use a cutting-edge mass spectrometry approach to map and measure the full shape and connections of disease-related proteins in human biology.

  NIH research University of Oklahoma · Norman, United States · NIH-11361645

• How mouth cooling and flavor taste influence eating behavior

  This project studies how temperature sensations in the mouth affect why people choose certain foods and flavors.

  NIH research University of Oklahoma · Norman, United States · NIH-11361127

• Helping antibiotics get inside hard-to-treat Gram-negative bacteria like Acinetobacter

  This project looks for ways to help antibiotics reach and kill tough Gram-negative bacteria that cause infections in people, such as Acinetobacter and Pseudomonas.

  NIH research University of Oklahoma · Norman, United States · NIH-11310196

• Local tumor heating plus immune stimulants to boost checkpoint therapy for metastatic pancreatic cancer

  This approach uses a targeted tumor-heating treatment together with immune-stimulating drugs to help people with advanced pancreatic cancer get a stronger response to immune checkpoint therapy.

  NIH research University of Oklahoma · Norman, United States · NIH-11294281

• How taste and body sensations shape food liking

  Researchers are mapping how taste and bodily sensations connect in the brain to better understand why some foods feel appealing or aversive for people with eating or taste problems.

  NIH research University of Oklahoma · Norman, United States · NIH-11287890

• Oklahoma Immunomodulation Center to Bring New Tools and Training

  A new center in Oklahoma will bring cutting-edge immunomodulation technologies and data science support to researchers, helping doctors and patients by accelerating immune-related discoveries.

  NIH research University of Oklahoma · Norman, United States · NIH-11269430

• Understanding ASPSCR1::TFE3 fusion in alveolar soft part sarcoma and its immune environment

  A research team is studying a rare cancer called alveolar soft part sarcoma and how a specific fusion protein might shape the tumor’s immune environment and reveal new treatment targets.

  NIH research University of Oklahoma · Norman, United States · NIH-11269429

• Neuroimaging-guided immunotherapy for glioblastoma

  A patient-facing overview of a project using advanced brain imaging to guide immunotherapy treatments for glioblastoma, aiming to improve how well these therapies work.

  NIH research University of Oklahoma · Norman, United States · NIH-11269427

• Immune response and coronavirus in migratory bats

  Researchers explore how stress from migration affects bat immunity and coronavirus shedding, with potential implications for human health.

  NIH research University of Oklahoma · Norman, United States · NIH-11269426

• Omics Data Science Core boosts bioinformatics support for immune research

  A new Omics Data Science Core in Oklahoma helps researchers analyze multi-omics data to better understand the human immune system and guide immunoengineering work.

  NIH research University of Oklahoma · Norman, United States · NIH-11269425

• Oklahoma Center of ImmunoEngineering supports immunology research and data science

  A center in Oklahoma helps immunology researchers work with big data to understand immune-related diseases and to develop scientists through career support.

  NIH research University of Oklahoma · Norman, United States · NIH-11269423

• Oklahoma Center of ImmunoEngineering (OCIE) to accelerate cancer and immune research

  A nationwide-friendly grant supports Oklahoma scientists in building a center that uses engineering and data science to study the immune system and its role in cancer, infections, and other diseases.

  NIH research University of Oklahoma · Norman, United States · NIH-11269422

• Ultrasound-activated protein nanostructures for targeted gene delivery

  This project develops tiny protein-built bubbles that are opened with ultrasound to deliver gene-editing tools to specific cells, aiming to help people who might need precise, localized gene therapies.

  NIH research University of Oklahoma · Norman, United States · NIH-11264854

• Combining CT scans and pathology slides to predict ovarian cancer treatment response

  This project is testing a computer-made image marker that combines CT scans and pathology slides to tell which ovarian cancer patients are likely to benefit from chemotherapy.

  NIH research University of Oklahoma · Norman, United States · NIH-11256732

• Oklahoma Cancer Medical Imaging Center

  This effort creates a center to develop advanced imaging tools and predictive markers to help people with cancer get more personalized screening, diagnosis, and treatment.

  NIH research University of Oklahoma · Norman, United States · NIH-11256725

• How tuberculosis bacteria move fats and drugs across their membranes

  This project aims to uncover how Mycobacterium tuberculosis uses MmpL proteins to transport lipids and drugs, with the goal of helping people with drug-resistant tuberculosis.

  NIH research University of Oklahoma · Norman, United States · NIH-11238489

• Chromosome-packing blockers for bacterial eye infections

  This project explores a new type of antibiotic that blocks how bacteria pack their DNA to help people with bacterial eye infections, such as those after surgery or from contact lenses.

  NIH research University of Oklahoma · Norman, United States · NIH-11171393

• How heavy metals change genes, behavior, and health using fruit flies

  Researchers are using fruit flies to learn how copper and other heavy metals change genes, body function, and behavior in ways that could matter for human health.

  NIH research University of Oklahoma · Norman, United States · NIH-11169886

• Developing tiny particles to deliver medicine for muscle conditions

  This project aims to create new ways to deliver medicines using very small particles, called nanoparticles, to help people with muscle diseases.

  NIH research University of Oklahoma · Norman, United States · NIH-11144453

• Role of brain-resident and incoming immune cells in inflammatory brain damage

  The team uses targeted drug-delivery tools to find out whether brain‑resident microglia or incoming blood immune cells drive brain damage in people after injury, infection, or autoimmune disease.

  NIH research University of Oklahoma · Norman, United States · NIH-11144336

• Improving how we see proteins to understand diseases

  This project aims to create better tools for looking closely at all the different forms of proteins in our bodies, which helps us understand how diseases start.

  NIH research University of Oklahoma · Norman, United States · NIH-11129844

• What controls differences in human skin and hair color

  Researchers are studying how gene switches and DNA packaging control melanin production to explain why people have different skin and hair colors.

  NIH research University of Oklahoma · Norman, United States · NIH-11129724

• How temperature affects our food choices and preferences

  This project explores how the temperature of food influences our taste experiences and eating behaviors.

  NIH research University of Oklahoma · Norman, United States · NIH-11110466

• Linking prebiotics to gut bacteria using advanced protein analysis

  This study is looking at how certain fibers in our diet, called prebiotics, help good bacteria in our gut thrive, and it aims to find out exactly which bacteria are doing the work and how they do it, so we can create better diets for improving gut health.

  NIH research University of Oklahoma · Norman, United States · NIH-11092918

• Exploring the ethics of genomic research in Indigenous communities

  This study is all about working closely with American Indian and Alaska Native communities to understand their needs and priorities in genomic research, making sure their voices are heard and respected while helping them lead their own research efforts.

  NIH research University of Oklahoma · Norman, United States · NIH-11089166

• Supporting early-stage researchers in structural biology projects

  This program is all about helping scientists who study the structure of biological molecules by giving them money and support to gather important early data, work together, and learn new techniques, so they can improve their research and make exciting discoveries.

  NIH research University of Oklahoma · Norman, United States · NIH-11083742

• Analyzing the 3D structures of proteins and nucleic acids to improve disease treatment

  This study is all about figuring out the shapes of important molecules in our bodies, like proteins and DNA, to help scientists create better medicines, which could eventually lead to new treatments for patients.

  NIH research University of Oklahoma · Norman, United States · NIH-11083736

• A facility for producing and analyzing proteins.

  This study is all about helping scientists create and understand proteins better, which can lead to new treatments and therapies for patients like you.

  NIH research University of Oklahoma · Norman, United States · NIH-11083730

• Management and support for a structural biology research center

  This study is all about making sure a research center in Oklahoma runs smoothly so that scientists can do their best work in understanding how our bodies are built, which could eventually help improve treatments for patients like you.

  NIH research University of Oklahoma · Norman, United States · NIH-11083728

• Exploring the relationship between macromolecular structure and function.

  This study is all about understanding how the shapes of important molecules in our bodies affect how they work, and it aims to help scientists work together better, which could eventually lead to new treatments for patients.

  NIH research University of Oklahoma · Norman, United States · NIH-11083727

• Enhancing immune response against metastatic pancreatic tumors using localized therapy

  This study is exploring a new way to treat advanced pancreatic cancer by using a special heat treatment to target tumors and boost the immune system, helping your body fight the cancer more effectively.

  NIH research University of Oklahoma · Norman, United States · NIH-11052594

• Understanding how mycobacterial proteins transport lipids and drugs

  This study is looking at how certain bacteria, like the one that causes tuberculosis, move fats and medicines around, which is important for finding new ways to treat tough infections that don't respond to regular drugs.

  NIH research University of Oklahoma · Norman, United States · NIH-11022509

• Creating ultrasound-activated protein structures for targeted therapy

  This study is exploring a new way to use sound waves to help deliver medicine directly to the right cells in your body, which could lead to better treatments for diseases with fewer side effects.

  NIH research University of Oklahoma · Norman, United States · NIH-11011319

• Improving ovarian cancer treatment predictions using advanced imaging techniques

  This study is looking to improve how doctors predict which ovarian cancer patients will respond well to chemotherapy by using advanced computer techniques to analyze CT scans and tissue images, helping to identify the best treatment options for each patient.

  NIH research University of Oklahoma · Norman, United States · NIH-11005785

• Using brain imaging to predict outcomes after brain tumor surgery

  This study is looking at how brain scans can help doctors plan safer surgeries for patients with gliomas, so they can remove more of the tumor while protecting important brain functions.

  NIH research University of Oklahoma · Norman, United States · NIH-11005783

Quick answers

How many clinical trials run by University of Oklahoma are recruiting right now?

65, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (64 trials), Laos (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 4: 6, Phase 1: 5, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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