Evaluating lung function improvement after bronchial thermoplasty in severe asthma patients
Official title: Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma
Run by University of Oklahoma · NCT02241265 · Data updated 2026-11-12
This study looks at how bronchial thermoplasty affects lung function in people with severe asthma by checking their breathing tests before and after the treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Status | Recruiting |
| Started | February 2014 |
| Main results expected | January 2026 |
| Study ends | September 2026 |
| Registry record updated | February 10, 2025 |
| Trial ID | NCT02241265 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with severe asthma and experiencing decreased FEV1.
✕Probably not a fit
Patients under 18 years of age will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to retrospectively analyze spirometry data from patients with severe asthma who have undergone bronchial thermoplasty. The researchers will review medical records from two centers, focusing on changes in forced expiratory volume (FEV1) before and after the thermoplasty procedure, which is performed in three sessions. The study will collect comprehensive data, including demographics and spirometric results, to assess the effectiveness of the treatment.
Why it matters
Potential benefit: If successful, this study could provide insights into the effectiveness of bronchial thermoplasty in improving lung function for patients with severe asthma.
How similar studies have gone: Previous studies have shown promising results for bronchial thermoplasty in asthma management, indicating that this approach has been tested with some success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years of age * severe asthma diagnosis * decreased FEV1 Exclusion Criteria: * \< 18 years of age
Where it's running
-
Ouhsc
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Brent Brown, MD — Ouhsc
- Study coordinator: Brent Brown, MD
- Email: brent-brown@ouhsc.edu
- Phone: 405-271-6173
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
-
HB0056 in adults with moderate to severe asthma
This study tests HB0056 versus a placebo to see if it helps adults with moderate to severe asthma reduce rescue inhaler use and improve symptoms.
-
Tilrekimig (PF-07275315) for Severe Asthma: Aimed at Adults with Frequent Exacerbations
This study tests whether tilrekimig helps people with severe asthma who have had multiple flare-ups in the past year, by comparing it to a placebo given every four weeks.
-
Inhaled CHF10136 safety and pharmacokinetics in healthy adults and adults with asthma
This first-in-human study tests inhaled CHF10136 to see if it is safe and well tolerated, how it behaves in the body, and how it affects adults with asthma compared with placebo.
-
Biologics for Type 2 Inflammation in Asthma and COPD in Real World
This real-world study tests whether six biologic drugs can reduce flare-ups and improve symptoms in adults with asthma or COPD treated in routine care in China.
-
GSK5784283 vs placebo in uncontrolled asthma (PERSIST ASTHMA-2)
A new medicine called GSK5784283 is being tested to see if it lowers asthma flare-ups better than a placebo in people with uncontrolled asthma.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.