Analyzing the 3D structures of proteins and nucleic acids to improve disease treatment
Official title: Biomolecular Structure Core
Funded at University of Oklahoma · NIH-11083736 · Data updated 2026-11-12
This study is all about figuring out the shapes of important molecules in our bodies, like proteins and DNA, to help scientists create better medicines, which could eventually lead to new treatments for patients.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma NIH-funded |
| Lab location | 1 site (Norman, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $285,383 |
| NIH project number | 5P30GM145423-04 |
| Project ID | NIH-11083736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with diseases that could be targeted by new therapeutics developed from insights gained through biomolecular structure analysis.
✕Less likely to help
Patients with conditions unrelated to the biological functions of proteins and nucleic acids may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the three-dimensional structures of proteins, nucleic acids, and their complexes, which are crucial for revealing their biological functions. By utilizing advanced techniques such as cryo-electron microscopy and robotic instrumentation for crystallization, the Biomolecular Structure Core aims to provide insights that can lead to the development of better therapeutics. The core supports various research groups in Oklahoma by offering state-of-the-art equipment and expertise in structure determination. Patients may benefit indirectly as this research could lead to new treatments for diseases based on the structural understanding of biomolecules.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapeutics for various human diseases.
How similar studies have gone: Other research in structural biology has shown success in developing therapeutics based on the understanding of biomolecular structures, indicating that this approach is both promising and validated.
Where this research is happening
-
University of Oklahoma
Norman, United States Active
Researchers
- Principal investigator: Thomas, Leonard M — University of Oklahoma
- Study coordinator: Thomas, Leonard M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.