Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 99

Non-invasive brain stimulation for improving memory after stroke

Official title: Post-Stroke Cognitive Impairment: Neurovascular Mechanisms and Non-Invasive Brain Stimulation

Run by University of Oklahoma · NCT06516588 · Data updated 2026-11-12

This study is testing whether a type of non-invasive brain stimulation can help improve memory and brain function in people who have had a stroke.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 99 Years
SexAll
Enrollment80 (estimated)
SponsorUniversity of Oklahoma
Academic / other
Locations1 site (Oklahoma City, Oklahoma)
StatusRecruiting
StartedSeptember 30, 2024
Main results expectedJune 30, 2026
Study endsJune 30, 2027
Registry record updatedOctober 10, 2024
Trial IDNCT06516588 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals who have experienced an ischemic stroke within the sub-acute phase and exhibit cognitive dysfunction.

Probably not a fit

Patients with severe psychiatric conditions, significant neurological disorders, or contraindications to tDCS may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of transcranial direct current stimulation (tDCS) on brain functioning and memory in individuals with post-stroke cognitive impairment (PSCI). It aims to understand how electrical stimulation influences brain activity, cerebral blood flow, and neuroinflammation biomarkers. The study employs non-invasive brain imaging techniques, including functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), alongside cognitive assessments and blood sample analysis. Participants will undergo various tests to determine the impact of stimulation on their cognitive abilities.

Why it matters

Potential benefit: If successful, this approach could enhance cognitive functioning and memory in patients recovering from stroke.

How similar studies have gone: Other studies using non-invasive brain stimulation techniques have shown promise in improving cognitive functions, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1\) ischemic stroke participants in sub-acute phase (at least 10 days after stroke event or discharge and under 5 months post-event) with cognitive dysfunction (MoCA \<26);

Exclusion Criteria:

1. clinically significant or unstable medical or psychiatric condition;
2. diagnosis of severe depression;
3. history of relevant neurological diagnosis (e.g., epilepsy);
4. previous neurosurgical procedure with craniectomy;
5. contraindications to tDCS (implanted brain medical devices);
6. severe visual impairment, hearing impairment, aphasia, neglect or dementia.

Where it's running

  • University of Oklahoma
    Oklahoma City, Oklahoma, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.