Non-invasive brain stimulation for improving memory after stroke
Official title: Post-Stroke Cognitive Impairment: Neurovascular Mechanisms and Non-Invasive Brain Stimulation
Run by University of Oklahoma · NCT06516588 · Data updated 2026-11-12
This study is testing whether a type of non-invasive brain stimulation can help improve memory and brain function in people who have had a stroke.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Status | Recruiting |
| Started | September 30, 2024 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | October 10, 2024 |
| Trial ID | NCT06516588 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals who have experienced an ischemic stroke within the sub-acute phase and exhibit cognitive dysfunction.
✕Probably not a fit
Patients with severe psychiatric conditions, significant neurological disorders, or contraindications to tDCS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effects of transcranial direct current stimulation (tDCS) on brain functioning and memory in individuals with post-stroke cognitive impairment (PSCI). It aims to understand how electrical stimulation influences brain activity, cerebral blood flow, and neuroinflammation biomarkers. The study employs non-invasive brain imaging techniques, including functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), alongside cognitive assessments and blood sample analysis. Participants will undergo various tests to determine the impact of stimulation on their cognitive abilities.
Why it matters
Potential benefit: If successful, this approach could enhance cognitive functioning and memory in patients recovering from stroke.
How similar studies have gone: Other studies using non-invasive brain stimulation techniques have shown promise in improving cognitive functions, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\) ischemic stroke participants in sub-acute phase (at least 10 days after stroke event or discharge and under 5 months post-event) with cognitive dysfunction (MoCA \<26); Exclusion Criteria: 1. clinically significant or unstable medical or psychiatric condition; 2. diagnosis of severe depression; 3. history of relevant neurological diagnosis (e.g., epilepsy); 4. previous neurosurgical procedure with craniectomy; 5. contraindications to tDCS (implanted brain medical devices); 6. severe visual impairment, hearing impairment, aphasia, neglect or dementia.
Where it's running
-
University of Oklahoma
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Study coordinator: Cheryl Adams, RN
- Email: gerolab@ouhsc.edu
- Phone: (405) 271-8130
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.