Non-invasive brain stimulation for improving memory after stroke
Post-Stroke Cognitive Impairment: Neurovascular Mechanisms and Non-Invasive Brain Stimulation
This study is testing whether a type of non-invasive brain stimulation can help improve memory and brain function in people who have had a stroke.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Trial ID | NCT06516588 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of transcranial direct current stimulation (tDCS) on brain functioning and memory in individuals with post-stroke cognitive impairment (PSCI). It aims to understand how electrical stimulation influences brain activity, cerebral blood flow, and neuroinflammation biomarkers. The study employs non-invasive brain imaging techniques, including functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), alongside cognitive assessments and blood sample analysis. Participants will undergo various tests to determine the impact of stimulation on their cognitive abilities.
Who should consider this trial
Good fit: Ideal candidates are individuals who have experienced an ischemic stroke within the sub-acute phase and exhibit cognitive dysfunction.
Not a fit: Patients with severe psychiatric conditions, significant neurological disorders, or contraindications to tDCS may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance cognitive functioning and memory in patients recovering from stroke.
How similar studies have performed: Other studies using non-invasive brain stimulation techniques have shown promise in improving cognitive functions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\) ischemic stroke participants in sub-acute phase (at least 10 days after stroke event or discharge and under 5 months post-event) with cognitive dysfunction (MoCA \<26); Exclusion Criteria: 1. clinically significant or unstable medical or psychiatric condition; 2. diagnosis of severe depression; 3. history of relevant neurological diagnosis (e.g., epilepsy); 4. previous neurosurgical procedure with craniectomy; 5. contraindications to tDCS (implanted brain medical devices); 6. severe visual impairment, hearing impairment, aphasia, neglect or dementia.
Where this trial is running
Oklahoma City, Oklahoma
- University of Oklahoma — Oklahoma City, Oklahoma, United States (Recruiting)
Study contacts
- Study coordinator: Cheryl Adams, RN
- Email: gerolab@ouhsc.edu
- Phone: (405) 271-8130
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.