Biopsy-site marker stiffness in breast cancer
Official title: Inflammation and Biopsy-site-marker in Breast Cancer (MOSAIC)
Run by University of Oklahoma · NCT07833566 · Data updated 2026-11-12
This observational study will see if the stiffness of biopsy-site markers relates to inflammation and potential spread in women with breast cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 140 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Status | Recruiting |
| Started | July 9, 2026 |
| Main results expected | July 2028 |
| Study ends | July 2030 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT07833566 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women with pathologically confirmed invasive breast cancer who had a biopsy-site marker placed at diagnosis and are scheduled for surgery at OU Health Stephenson Cancer Center.
✕Probably not a fit
Patients with non-invasive breast conditions, those not undergoing surgery, or those with conditions excluding participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective study collects tissue samples from breast cancer patients who received a biopsy-site marker at diagnosis to explore whether marker stiffness is linked to pro-metastatic inflammatory changes. Researchers will examine associations between marker type and inflammatory pathways after biopsy. The study does not involve testing an intervention beyond marker placement and tissue analysis, and it is conducted at a single center. Findings could shed light on whether marker properties influence the tumor microenvironment. Participants are women over 18 with confirmed invasive breast cancer scheduled for surgery.
Why it matters
Potential benefit: If associations are found, results could inform marker selection to minimize inflammatory changes and potential metastasis risk.
How similar studies have gone: Prior marker-related biology studies have shown tissue reactions can vary with materials, but this exact stiffness–inflammation link in breast cancer is not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Written informed consent (ICF) signed and dated by the patient prior to the performance of any study-specific procedures, sampling, or analyses. * Female patients at \> 18 years of age at the time of signature of the ICF. * Pathologically verified invasive breast cancer cases referred to OU for surgery. Exclusion Criteria: * Patients who had a biopsy at OUBI OKC. * Patient who will undergo neoadjuvant therapy * Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension, uncontrolled diabetes mellitus, active bleeding diatheses, or active viral infection, including hepatitis B, hepatitis C, and human immunodeficiency virus. Screening for chronic conditions is not required. * Currently pregnant or breastfeeding * Patients not eligible for surgery * Prisoners
Where it's running
-
OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Takemi Tanaka, PhD — University of Oklahoma - Stephenson Cancer Center
- Study coordinator: Lead Onco Nurse
- Email: SCC-IIT-Office@ouhsc.edu
- Phone: 405-271-8777
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.