Creating ultrasound-activated protein structures for targeted therapy
Official title: Development of protein-based nanostructures activated by ultrasound
Funded at University of Oklahoma · NIH-11011319 · Data updated 2026-11-12
This study is exploring a new way to use sound waves to help deliver medicine directly to the right cells in your body, which could lead to better treatments for diseases with fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma NIH-funded |
| Lab location | 1 site (Norman, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $315,903 |
| NIH project number | 5R01GM152704-02 |
| Project ID | NIH-11011319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced diseases that may benefit from innovative gene therapies and targeted treatments.
✕Less likely to help
Patients with conditions that do not involve gene therapy or those who are not candidates for advanced treatment modalities may not benefit from this research.
What this research studies
This research focuses on developing innovative protein-based nanostructures that can be activated by ultrasound to deliver therapeutic agents directly to specific cells. By utilizing gas vesicles and ultrasound technology, the project aims to enhance the efficiency and safety of delivering gene-editing tools and other macromolecules to treat diseases. Patients may benefit from improved therapies that target their conditions more precisely, potentially leading to better outcomes with fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for various diseases, particularly in cancer therapy.
How similar studies have gone: Other research has shown promise in using ultrasound and nanoparticles for targeted drug delivery, indicating that this approach could be effective.
Where this research is happening
-
University of Oklahoma
Norman, United States Active
Researchers
- Principal investigator: Yoon, Sangpil — University of Oklahoma
- Study coordinator: Yoon, Sangpil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.