Oklahoma Native American smoking cessation and pain risk IV
Official title: Can Smoking Cessation Improve Physiological Markers of Chronic Pain Risk in Native American Smokers?: A Pilot Feasibility Study
Run by University of Oklahoma · NCT07080788 · Data updated 2026-11-12
This pilot will try 4 weeks of verified smoking abstinence with financial incentives to see if it lowers physiological signs of chronic pain risk in adult Native American daily smokers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Tulsa, Oklahoma) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | March 2, 2026 |
| Trial ID | NCT07080788 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult self-identified Native American daily smokers who do not have current chronic pain, can speak and read English, own a smartphone with a data plan, and meet safety criteria (not pregnant, no serious heart disease, no psychosis or significant cognitive impairment).
✕Probably not a fit
People with current chronic pain, pregnant individuals, those with significant heart disease, active psychosis, or serious cognitive impairment are excluded and therefore unlikely to benefit from this pilot's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot interventional study enrolls adult self-identified Native American daily smokers without current chronic pain and uses financial incentives to support smoking cessation. Participants who achieve verified 4-week abstinence will undergo quantitative sensory testing to measure pain amplification and pain inhibition, compared with non-abstinent participants. The study is designed to determine feasibility and to estimate effect sizes for changes in pain regulation and for variables in a conceptual model linking smoking to pain risk in this population. All visits take place at the University of Oklahoma Schusterman Center in Tulsa and require a smartphone for study procedures and monitoring.
Why it matters
Potential benefit: If successful, quitting smoking could reduce pain amplification and improve pain inhibition, potentially lowering long-term chronic pain risk among Native American smokers.
How similar studies have gone: Prior work in non-Native populations links smoking to disrupted pain regulation and shows pain can improve after quitting, but testing these mechanisms specifically in Native American smokers is novel and largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-identify as Native American/American Indian * Currently daily smoker * Own a smartphone with a data plan * Ability to speak and read English Exclusion Criteria: * \>18 years of age * Currently pregnant * Self-reported history of heart disease or heart attack * Angina, arrhythmias, hypertension, heart disease * Current chronic pain * Pepper allergy * Inability to speak English * Current psychosis (assessed by Psychosis Screening Questionnaire) * Serious cognitive impairment (assessed by \<20 score on the Montreal Cognitive Assessment \[MoCA\])
Where it's running
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University of Oklahoma - Schusterman Center
Tulsa, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Jamie L Rhudy, PhD — University of Oklahoma Health Sciences
- Study coordinator: PLAN Lab
- Email: tulsa.plan@gmail.com
- Phone: 918-660-3048
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.