Meloxicam for pain after Mohs surgery
Official title: Meloxicam for Postoperative Pain in Mohs Micrographic Surgery
Run by University of Oklahoma · NCT07200544 · Data updated 2026-11-12
This trial will try two doses of meloxicam plus acetaminophen versus acetaminophen with alternating ibuprofen to see which controls pain best for adults having Mohs skin cancer surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Status | Recruiting |
| Started | October 15, 2025 |
| Main results expected | June 2, 2026 |
| Study ends | August 2, 2026 |
| Registry record updated | December 15, 2025 |
| Trial ID | NCT07200544 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who consent and are undergoing Mohs micrographic surgery at the University of Oklahoma, and who do not meet exclusion criteria, are eligible.
✕Probably not a fit
Patients who are pregnant, have significant liver disease, stage III+ chronic kidney disease, aspirin-sensitive asthma, chronic NSAID use, active GI bleeding or peptic ulcer disease, problematic drug-interaction risk, or who cannot participate in English will be excluded and may not receive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing Mohs micrographic surgery at the University of Oklahoma will be assigned to one of three single-dose postoperative regimens: meloxicam 7.5 mg plus acetaminophen 500 mg, meloxicam 15 mg plus acetaminophen 500 mg, or acetaminophen 500 mg followed by alternating ibuprofen 200 mg and acetaminophen 500 mg. Pain intensity and patient satisfaction will be measured using postoperative surveys. The trial aims to compare short-term pain control and patient-reported comfort between the meloxicam options and the more common alternating ibuprofen/acetaminophen approach. Standard surgical care and safety monitoring will continue alongside the pain-management regimen.
Why it matters
Potential benefit: If successful, this could offer a simpler single-dose meloxicam option that provides equal or better pain relief and improves postoperative comfort after Mohs surgery.
How similar studies have gone: NSAIDs and alternating acetaminophen/ibuprofen regimens have been used successfully for postoperative pain in dermatologic and minor surgical settings, but data specifically on meloxicam for pain after Mohs surgery are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients who consents to the study and are undergoing Mohs micrographic surgery at the University of Oklahoma. Exclusion Criteria: * Women who are pregnant, suspected to be pregnant, or planning to become pregnant during the study period will be excluded from participation. * Chronic liver disease (chronic hepatitis, acute hepatitis, cirrhosis, NASH, NAFLD, alcoholic liver disease, hemochromatosis, Wilson's disease) * Chronic kidney disease stage III or greater, * Aspirin-sensitive asthma * History of chronic NSAID use * Patients vulnerable to drug interactions * GI bleeds * Peptic ulcers * Non-English speakers
Where it's running
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Lindsey Collins, MD — University of Oklahoma, Department of Dermatology
- Study coordinator: Chase Pitchford, MD
- Email: chase-pitchford@ouhsc.edu
- Phone: 405-271-6110
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.