Meloxicam for pain after Mohs surgery
Meloxicam for Postoperative Pain in Mohs Micrographic Surgery
This trial will try two doses of meloxicam plus acetaminophen versus acetaminophen with alternating ibuprofen to see which controls pain best for adults having Mohs skin cancer surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Oklahoma City, Oklahoma) |
| Trial ID | NCT07200544 on ClinicalTrials.gov |
What this trial studies
Adults undergoing Mohs micrographic surgery at the University of Oklahoma will be assigned to one of three single-dose postoperative regimens: meloxicam 7.5 mg plus acetaminophen 500 mg, meloxicam 15 mg plus acetaminophen 500 mg, or acetaminophen 500 mg followed by alternating ibuprofen 200 mg and acetaminophen 500 mg. Pain intensity and patient satisfaction will be measured using postoperative surveys. The trial aims to compare short-term pain control and patient-reported comfort between the meloxicam options and the more common alternating ibuprofen/acetaminophen approach. Standard surgical care and safety monitoring will continue alongside the pain-management regimen.
Who should consider this trial
Good fit: Adults who consent and are undergoing Mohs micrographic surgery at the University of Oklahoma, and who do not meet exclusion criteria, are eligible.
Not a fit: Patients who are pregnant, have significant liver disease, stage III+ chronic kidney disease, aspirin-sensitive asthma, chronic NSAID use, active GI bleeding or peptic ulcer disease, problematic drug-interaction risk, or who cannot participate in English will be excluded and may not receive benefit.
Why it matters
Potential benefit: If successful, this could offer a simpler single-dose meloxicam option that provides equal or better pain relief and improves postoperative comfort after Mohs surgery.
How similar studies have performed: NSAIDs and alternating acetaminophen/ibuprofen regimens have been used successfully for postoperative pain in dermatologic and minor surgical settings, but data specifically on meloxicam for pain after Mohs surgery are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients who consents to the study and are undergoing Mohs micrographic surgery at the University of Oklahoma. Exclusion Criteria: * Women who are pregnant, suspected to be pregnant, or planning to become pregnant during the study period will be excluded from participation. * Chronic liver disease (chronic hepatitis, acute hepatitis, cirrhosis, NASH, NAFLD, alcoholic liver disease, hemochromatosis, Wilson's disease) * Chronic kidney disease stage III or greater, * Aspirin-sensitive asthma * History of chronic NSAID use * Patients vulnerable to drug interactions * GI bleeds * Peptic ulcers * Non-English speakers
Where this trial is running
Oklahoma City, Oklahoma
- University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States (Recruiting)
Study contacts
- Principal investigator: Lindsey Collins, MD — University of Oklahoma, Department of Dermatology
- Study coordinator: Chase Pitchford, MD
- Email: chase-pitchford@ouhsc.edu
- Phone: 405-271-6110
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.