Understanding pain risk in Native American adults related to stress and discrimination
Official title: The Impact of Structural Racism and Discrimination (SRD) on Mechanisms of the Native American Pain Disparity
Run by University of Oklahoma · NCT05723081 · Data updated 2026-11-12
This study looks at how stress and discrimination affect chronic pain risk in Native American adults to see if there are ways to help reduce their pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | University of Oklahoma Academic / other |
| Locations | 1 site (Tulsa, Oklahoma) |
| Status | Recruiting |
| Started | February 3, 2023 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | April 2, 2025 |
| Trial ID | NCT05723081 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Native American adults who do not currently experience chronic pain.
✕Probably not a fit
Patients under 18 years of age or those with a history of certain medical conditions or current chronic pain will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates how environmental structural racism and discrimination impact chronic pain risk among Native American adults. It aims to explore the mechanisms by which these societal stressors contribute to increased pain sensitivity and the transition to chronic pain. Additionally, the study will examine psychosocial factors that may help mitigate the negative effects of these stressors on pain perception. By focusing on this underserved population, the research seeks to uncover critical insights into the disparities in chronic pain prevalence.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and interventions for chronic pain management in Native American communities.
How similar studies have gone: While there is limited research specifically targeting this population, studies on the effects of stress and discrimination on health outcomes have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Self-identify as Native American/American Indian Exclusion Criteria: * \<18 years of age * Self-reported history of cardiovascular, neuroendocrine, musculoskeletal, or neurological disorders * Surrent chronic pain, defined as persistent, bothersome pain on more days than not for at least 3 months) * Self-reported current substance dependence * Sse of medication that could interfere with testing (e.g., recent use of analgesics, antidepressants, or anti-anxiety medications) * Inability to speak English * Current psychosis (assessed by Psychosis Screening Questionnaire) * Serious cognitive impairment (assessed by \<20 score on the Montreal Cognitive Assessment \[MoCA\]) * Possible peripheral neuropathy (assessed by nerve conduction study)
Where it's running
-
University of Oklahoma - Schusterman Center
Tulsa, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Jamie L Rhudy, PhD — University of Oklahoma
- Study coordinator: PLAN Lab
- Email: tulsa.plan@gmail.com
- Phone: 918-660-3048
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.