Using ketamine to manage pain after hemorrhoid surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of ketamine as a pain management option for patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. Approximately 100 participants will be randomly assigned to receive either an intraoperative ketamine infusion or standard anesthesia without ketamine. The study will assess post-operative pain levels using numeric rating scales and follow-up evaluations at two weeks post-surgery. All participants will receive standardized post-operative care and pain management instructions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-100
* Undergoing a hemorrhoidectomy for Grade III or IV hemorrhoids.

Exclusion Criteria:

* Inability to undergo general anesthesia
* Contraindications to hemorrhoidectomy
* History of schizophrenia or other hallucinatory psychiatric illnesses
* History of psychosis
* Chronic narcotic usage defined as either having a pain contract with a pain management specialist and no narcotic usage for one month prior to hemorrhoidectomy.

Where it's running

• University of Oklahoma Health Sciences Center
  Oklahoma City, Oklahoma, United States Recruiting

Study contacts

• Principal investigator: Steven N Carter, MD — University of Oklahoma
• Study coordinator: Steven N Carter, MD
• Email: steven-carter@ouhsc.edu
• Phone: 405-271-8001

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ligasure vs. Conventional Diathermy in Hemorrhoidectomy

  This study tests whether using the Ligasure device during hemorrhoidectomy reduces pain and bleeding compared with conventional diathermy in patients with symptomatic hemorrhoids.

  Recruiting Sohag University · Sohag · NCT07878546

• Sutureless hemorrhoidectomy vs conventional ligation for advanced hemorrhoids

  This study tests whether a sutureless, energy-based hemorrhoidectomy can reduce pain and recovery time compared with the standard Milligan-Morgans procedure in adults with Grade III–IV hemorrhoids.

  Recruiting Sohag University · Sohag · NCT07824999

• Botulinum toxin A injection before hemorrhoid surgery to reduce postoperative pain

  This study will see if injecting botulinum toxin A into the internal anal sphincter a week before hemorrhoidectomy reduces post-operative pain for adults with grade III–IV hemorrhoids.

  Recruiting Phase 2 Lomonosov Moscow State University Medical Research and Educational Center · Moscow, Moscow · NCT07399860

• Pudendal nerve block versus sacral erector spinae (ESP) block for pain after hemorrhoidectomy

  This will test whether the sacral erector spinae (ESP) block gives equal or better pain relief than the pudendal nerve block for adults having elective hemorrhoid surgery.

  Recruiting Ente Ospedaliero Cantonale, Bellinzona · Bellinzona · NCT07350460

• Are hemorrhoids linked to varicose veins in the legs?

  This project will see if adults with hemorrhoids are more likely to have varicose veins in their lower limbs by comparing 200 people with hemorrhoids to 200 patients with other benign anorectal conditions.

  Recruiting Aydin Adnan Menderes University · Aydin, Efeler · NCT07317492

• Ultrasound-guided sacral erector spinae plane block versus saddle block for anesthesia during hemorrhoidectomy

  This will test whether an ultrasound-guided sacral erector spinae plane block works as well as a saddle block for adults having hemorrhoidectomy.

  Recruiting Ain Shams University · Cairo · NCT06969274

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.