Effects of physical activity on neuroinflammation in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between physical activity and neuroinflammation in individuals diagnosed with Parkinson's disease. It aims to understand how physical activity may influence inflammatory processes associated with the disease, particularly focusing on the role of neuroinflammation in disease progression. Participants will be assessed based on their physical activity levels and the presence of neuroinflammatory markers. The study includes individuals aged 40 to 80 years with a confirmed diagnosis of Parkinson's disease and specific clinical criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects of both sexes, aged between 40 and 80 years (extremes included)
* Diagnosis of Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society
* Hoehn \& Yahr between 1 and 3

Exclusion Criteria:

* Concomitant diagnosis of other neurological diseases
* Presence of confirmed cognitive decline (MMSE \< 24)
* Presence of depression with (BDI \> 40)
* Patients with deep brain stimulation implant or undergoing DuoDopa therapy
* Presence of significant diseases affecting the musculoskeletal system
* Presence of internal medicine conditions, considered clinically significant by the investigator
* Acute or recent infections
* Body Mass Index (BMI) \>= 30
* Active smoking behavior
* Ongoing treatment with N-acetylcysteine or anti-oxidants
* Pregnancy or lactation

Where it's running

• IRCCS Mondino Foundation
  Pavia, Pavia, Italy Recruiting

Study contacts

• Study coordinator: Roberto De Icco
• Email: roberto.deicco@mondino.it
• Phone: +390382380425

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.