Effects of physical activity on neuroinflammation in Parkinson's disease
Role of Physical Activity on Neuroinflammation in Parkinson's Disease
This study is testing if being physically active can help reduce inflammation in the brains of people with Parkinson's disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | IRCCS National Neurological Institute "C. Mondino" Foundation Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Trial ID | NCT06977204 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between physical activity and neuroinflammation in individuals diagnosed with Parkinson's disease. It aims to understand how physical activity may influence inflammatory processes associated with the disease, particularly focusing on the role of neuroinflammation in disease progression. Participants will be assessed based on their physical activity levels and the presence of neuroinflammatory markers. The study includes individuals aged 40 to 80 years with a confirmed diagnosis of Parkinson's disease and specific clinical criteria.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 40 to 80 years with a clinical diagnosis of Parkinson's disease and a Hoehn & Yahr stage between 1 and 3.
Not a fit: Patients with significant cognitive decline, other neurological diseases, or those undergoing specific treatments like deep brain stimulation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into how physical activity may mitigate neuroinflammation and potentially slow the progression of Parkinson's disease.
How similar studies have performed: Previous studies have indicated a potential link between physical activity and reduced neuroinflammation in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects of both sexes, aged between 40 and 80 years (extremes included) * Diagnosis of Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society * Hoehn \& Yahr between 1 and 3 Exclusion Criteria: * Concomitant diagnosis of other neurological diseases * Presence of confirmed cognitive decline (MMSE \< 24) * Presence of depression with (BDI \> 40) * Patients with deep brain stimulation implant or undergoing DuoDopa therapy * Presence of significant diseases affecting the musculoskeletal system * Presence of internal medicine conditions, considered clinically significant by the investigator * Acute or recent infections * Body Mass Index (BMI) \>= 30 * Active smoking behavior * Ongoing treatment with N-acetylcysteine or anti-oxidants * Pregnancy or lactation
Where this trial is running
Pavia, Pavia
- IRCCS Mondino Foundation — Pavia, Pavia, Italy (Recruiting)
Study contacts
- Study coordinator: Roberto De Icco
- Email: roberto.deicco@mondino.it
- Phone: +390382380425
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.