Clinical trial Recruiting at 1 site Interventional Ages 18 to 95

Improving positive emotions and physical activity after heart events

Official title: A Novel Psychological-behavioral Intervention to Promote Physical Activity After Acute Coronary Syndrome

Run by Massachusetts General Hospital · NCT05412862 · Data updated 2026-11-12

This study is trying out a new program that combines positive thinking and motivation to help people recovering from heart events get more active and feel better compared to regular care.

Quick facts

Study typeInterventional
Ages18 Years to 95 Years
SexAll
Enrollment280 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedSeptember 12, 2022
Main results expectedMarch 31, 2028
Study endsMarch 31, 2028
Registry record updatedApril 20, 2026
Trial IDNCT05412862 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals who have experienced an acute coronary syndrome event and demonstrate low levels of physical activity.

Probably not a fit

Patients with cognitive deficits, severe depression, or other medical conditions that prevent participation in physical activity may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests a 12-week intervention using positive psychology and motivational interviewing delivered remotely to patients recovering from acute coronary syndrome (ACS). Participants will receive additional text messages over 24 weeks to encourage physical activity and monitor their progress. The goal is to compare the effectiveness of this intervention against standard post-ACS treatment in improving physical activity, psychological well-being, and cardiovascular health outcomes. The study will enroll 280 patients who have low baseline physical activity levels following their ACS event.

Why it matters

Potential benefit: If successful, this intervention could enhance recovery and quality of life for patients after acute coronary syndrome by promoting physical activity and positive emotions.

How similar studies have gone: Other studies have shown promise in using motivational interviewing and positive psychology to improve health outcomes, suggesting this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ACS (myocardial infarction or unstable angina)
* Suboptimal physical activity (score of \< 6 on the Medical Outcomes study Specific Adherence Scale item related to physical activity)

Exclusion Criteria:

* Cognitive deficits (assessed via a 6-item cognitive screening tool)
* Medical conditions likely to lead to death within 6 months.
* Moderate-severe depression (Patient Health Questionnaire-9 \[PHQ-9\] score ≥15)
* Inability to participate in physical activity due to another medical condition (e.g., arthritis)
* Inability to read, write, or speak in English
* Inability to receive text-messages
* Current participation in another intervention or program that has been designed to promote well-being or physical activity

Where it's running

  • Massachusetts General Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Jeff C Huffman, M.D. — Massachusetts General Hospital
  • Study coordinator: Jeff C Huffman, M.D.
  • Email: jhuffman@partners.org
  • Phone: 617-724-2910

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.