Investigating the effects of aging on insulin resistance and obesity
Official title: In French AGIR Means to Get Into Action. This is the Generic Title of Our Study.
Run by University of Lausanne · NCT01224886 · Data updated 2026-11-12
This study is testing how physical activity can help older adults aged 60-80 improve their insulin sensitivity and manage obesity as they age.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years to 80 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Lausanne Academic / other |
| Locations | 2 sites (Bern and 1 other locations) |
| Status | Recruiting |
| Started | October 2010 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | December 5, 2024 |
| Trial ID | NCT01224886 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 60-80 who are either sedentary or highly trained and have a BMI between 18-40.
✕Probably not a fit
Patients with known diabetes, significant cardiovascular or other health issues, or those on medications affecting glucose metabolism may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the relationship between aging, insulin resistance, and obesity in older adults. It focuses on how physical inactivity and ectopic lipid accumulation may contribute to insulin resistance, a key factor in the development of type 2 diabetes. Participants aged 60-80, whether sedentary or highly trained, will engage in a physical activity intervention to assess its impact on their insulin sensitivity. The study aims to clarify the role of aging in insulin resistance amidst the rising prevalence of obesity and diabetes in older populations.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for managing insulin resistance and reducing the risk of type 2 diabetes in older adults.
How similar studies have gone: Other studies have shown promising results in addressing insulin resistance through physical activity, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 60-80 * Sedentary or highly trained * BMI 18-40 * Non-Smoker * Normal glucose tolerance or impaired glucose tolerance * Willingness to comply with the protocol Exclusion Criteria: * Contraindication to moderate exercise or clinical conditions precluding from joining an exercise program, such as clinically significant cardiovascular disease, peripheral vascular disease, uncontrolled hypertension, neurological or orthopedic disease * Recent weight loss or weight gain * Known diabetes * Known drugs to affect glucose homeostasis such as nicotinic acid, glucocorticoids * Severe anemia or lipid disturbances, hepatic or renal disease * Recent history of cancer * Hypothyroidism * Recent hormone replacement therapy * Known allergy to lidocaine or other local anesthetic * Positive stress test * Active alcohol or substance abuse
Where it's running
-
UNIL and CHUV
Lausanne, Switzerland Recruiting -
University of Bern
Bern, Switzerland Active not recruiting
Study contacts
- Principal investigator: Francesca Amati, MD,PhD — University of Lausanne
- Study coordinator: Francesca Amati, MD, PhD
- Email: francesca.amati@unil.ch
- Phone: +41 21 692 5552
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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-
Using robots to help older adults become more physically active
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-
MetAGE: deep phenotyping of how metabolism affects aging and disease
This project will test blood-based aging biomarkers in adults of different ages and weights to see if metabolic differences relate to aging and cardiometabolic disease.
-
Resistance exercise training for older women with obesity
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Personalized exercise program for cardiac outpatients
This study is testing a personalized exercise program to see if it helps people with stable heart conditions improve their fitness and quality of life over time.
-
Improving physical activity in older adults living with HIV
This study is testing three different ways to help older adults living with HIV be more active, including coaching, therapy for motivation, and a social support system using Fitbits, to see which method works best.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.