Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Preventive physical activity for head and neck cancer patients

Official title: Preventive Randomized Study Regarding Physical Activity Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer: the Effect of Preventive Intervention for Physical Activity, Function and Quality of Life

Run by Sahlgrenska University Hospital · NCT05432297 · Data updated 2026-11-12

This study tests if a special exercise program can help head and neck cancer patients feel better and function well during their radiation treatment.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment80 (estimated)
SponsorSahlgrenska University Hospital
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Gothenburg)
StatusRecruiting
StartedJanuary 2, 2023
Main results expectedDecember 2027
Study endsDecember 2032
Registry record updatedApril 23, 2026
Trial IDNCT05432297 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients diagnosed with head and neck cancer who are set to receive radiotherapy with curative intent.

Probably not a fit

Patients who have undergone surgery for head and neck cancer or those unable to participate in the exercise intervention will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves patients with tumors of the oropharynx, larynx, and hypopharynx who are scheduled to receive radiotherapy with curative intent. Participants will be randomly assigned to either a preventive physical activity intervention group or a control group that does not engage in a specified exercise protocol. Throughout the treatment, all patients will receive weekly support from a speech language pathologist or physical therapist. The aim is to enhance physical function and improve quality of life during and after oncologic treatment.

Why it matters

Potential benefit: If successful, this intervention could significantly improve physical function and quality of life for patients undergoing treatment for head and neck cancer.

How similar studies have gone: While similar approaches have been explored, this specific preventive physical activity intervention in the context of head and neck cancer treatment is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Head and neck cancer (tumors of the oropharynx, pharynx, hypopharynx and larynx)
* Receiving radiohterapy (+/- chemotherapy) with curative intent

Exclusion Criteria:

* Surgery due to head and neck cancer
* Previous treatment for head and neck cancer
* Tracheostomized patients
* Inability to perform exercise intervention
* Inability to perform part of 6-minute walking test
* Inability to independently fill out questionnaires in Swedish
* Previous neurologic or neuromuscular disease

Where it's running

  • Sahlgrenska University Hospital
    Gothenburg, Sweden
    Recruiting

Study contacts

  • Principal investigator: Lisa Tuomi, PhD — Sahlgrenska University Hospital
  • Study coordinator: Lisa Tuomi, PhD
  • Email: tuomi.lisa@gu.se
  • Phone: +46313421000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.