Clinical trial Recruiting at 1 site Observational Ages 18 to 64

Examining health impacts of past sports injuries and inactivity

Official title: Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

Run by Marquette University · NCT05344001 · Data updated 2026-11-12

This study is trying to see how past sports injuries and being inactive affect the long-term health of former athletes compared to non-athletes.

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Quick facts

Study typeObservational
Ages18 Years to 64 Years
SexAll
Enrollment450 (estimated)
SponsorMarquette University
Academic / other
Locations1 site (Milwaukee, Wisconsin)
StatusRecruiting
StartedApril 18, 2022
Main results expectedAugust 2026
Study endsAugust 2027
Registry record updatedFebruary 25, 2026
Trial IDNCT05344001 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include current or former collegiate varsity athletes aged 18-25 or 40-64, as well as non-athlete controls within the same age ranges.

Probably not a fit

Patients with neurologic or degenerative diseases that impair function, those who are pregnant, or individuals with lower extremity joint replacements will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the long-term health outcomes of former competitive athletes, particularly focusing on those with prior knee injuries, compared to non-athlete controls. It aims to assess various health indicators, including strength, function, physical activity levels, dietary patterns, and cardiometabolic health among participants aged 18-25 and 40-64. The study will also explore how sedentary behavior and physical activity patterns differ between current athletes and non-athletes, as well as track changes in these variables over time. The overarching goal is to understand how prior injuries and inactivity contribute to poor health in midlife.

Why it matters

Potential benefit: If successful, this study could provide insights into how to improve long-term health outcomes for former athletes and inform interventions to mitigate risks associated with past injuries and sedentary behavior.

How similar studies have gone: While this study explores a specific aspect of health in former athletes, similar studies have shown that understanding the impact of injuries and physical activity on long-term health can lead to meaningful insights and interventions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Please see cohorts for specific inclusion/exclusion criteria

Inclusion Criteria:

* Age 18-25 years OR age 40-64 years
* Current or former collegiate varsity athlete OR non-athlete control

Exclusion Criteria:

* Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
* Pregnancy
* Lower extremity joint replacement (e.g., hip or knee replacement)

Where it's running

  • Marquette University
    Milwaukee, Wisconsin, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.