Effects of daily calorie reduction on kidney health in overweight adults with ADPKD
Official title: Daily Caloric Restriction in Overweight and Obese Adults with ADPKD
Funded at University of Colorado Denver · NIH-11098556 · Data updated 2026-11-12
This study is looking at how eating fewer calories each day might help improve kidney health for adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese, and it aims to see if this can slow down kidney problems while also helping with weight management.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $515,538 |
| NIH project number | 5R01DK129259-05 |
| Project ID | NIH-11098556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with ADPKD and are overweight or obese.
✕Less likely to help
Patients who are not overweight or obese or those with rapidly progressing ADPKD who are already on tolvaptan may not benefit from this research.
What this research studies
This research investigates how daily caloric restriction can impact kidney health in adults suffering from autosomal dominant polycystic kidney disease (ADPKD) who are also overweight or obese. The study aims to explore the potential benefits of reducing calorie intake to slow the progression of kidney disease, leveraging insights from previous animal studies that suggest metabolic changes can positively affect kidney function. Participants will be monitored for changes in kidney size and function, as well as overall health improvements related to weight management.
Why it matters
Potential benefit: If successful, this research could provide a non-pharmacological approach to slowing kidney disease progression in patients with ADPKD.
How similar studies have gone: Previous studies have shown promising results in animal models regarding caloric restriction and kidney health, indicating potential for success in human trials.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Nowak, Kristen Lynn — University of Colorado Denver
- Study coordinator: Nowak, Kristen Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.