How weight changes impact knee osteoarthritis in overweight individuals
Understanding the mechanisms by which weight change affects progression of knee osteoarthritis in obese and overweight individuals: An analysis of the Osteoarthritis Initiative Dataset
This study is looking at how losing or gaining weight might change how knee osteoarthritis gets worse in people who are overweight or obese, with the hope of finding ways to help keep their knees healthier for longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10809722 on NIH RePORTER |
What this research studies
This research investigates how changes in body weight affect the progression of knee osteoarthritis (OA) in obese and overweight individuals. By analyzing data from the Osteoarthritis Initiative, the study aims to understand the underlying mechanisms, such as inflammation and body composition changes, that contribute to OA progression. The goal is to identify specific factors that can help slow down the deterioration of knee joints, potentially leading to more effective treatment strategies for those affected by OA.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese or overweight individuals who are experiencing symptoms of knee osteoarthritis.
Not a fit: Patients who are not overweight or do not have knee osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that effectively slow the progression of knee osteoarthritis in overweight patients.
How similar studies have performed: Previous research has shown that weight loss can slow the progression of osteoarthritis, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Link, Thomas M — University of California, San Francisco
- Study coordinator: Link, Thomas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.