Condition

End Stage Renal Disease clinical trials and research

• 41Clinical trials
• 15NIH research projects
• 23Countries

Newest End Stage Renal Disease clinical trials

All recruiting trials (41)

• Ribupatide PK in People with Kidney Impairment

  This study tests how a single shot of ribupatide behaves in the body for people with severe kidney problems compared to those with normal kidney function.

  Recruiting at 2 sites Phase 1 Kailera · Orlando, Florida and 1 other locations · NCT07793929

• Intradiay dialysis exercise to improve posture in adults with end-stage kidney disease

  This study tests whether a 12-week supervised exercise program done during dialysis can improve posture in adults on maintenance hemodialysis.

  Recruiting Pardis Specialized Wellness Institute · Isfahan · NCT07720401

• Pumpkin seed oil for people on hemodialysis

  This study tests whether taking pumpkin seed oil daily for 3 months helps reduce inflammation and improve-related lab markers in people with end-stage kidney disease on dialysis.

  Recruiting Al-Mustansiriyah University · Baghdad, Karkh · NCT07710183

• Porcine thymokidney transplant for end-stage renal disease

  This study tests whether a GalKO porcine thymokidney transplant can keep kidney function without dialysis in adults with end-stage kidney disease who are unlikely to get a standard donor kidney soon.

  Recruiting Phase 1 Xeno Holdings (US), LLC dba ChoironeX · New York, New York and 1 other locations · NCT07696962

• How inflammatory diseases change the way your body handles medicines.

  This study will see if inflammatory conditions like type 2 diabetes, IBD, or end-stage kidney disease change how common medicines are processed and increase the chance of side effects.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07360938

• CRISPR-edited donor kidney transplant to reduce rejection risk

  This trial will see if donor kidneys edited with CRISPR to turn off key HLA genes can lower rejection in adults with end-stage kidney disease receiving transplants.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053462

• Magnetic stimulation to relieve low back pain and preserve muscle in people with end-stage kidney disease

  This test uses magnetic stimulation to try to reduce low back pain and help maintain muscle mass in adults on frequent dialysis for end-stage renal disease.

  Recruiting Bundang CHA Hospital · Seongnam-si, Gyeonggi-do · NCT06982573

• Walking with dogs to improve breathing and physical tolerance in adolescents with kidney failure

  This study is testing if walking with dogs can help teenagers with kidney failure breathe better and feel stronger during their dialysis treatments.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT06861816

• TLR4 gene change and periodontitis in adults with end-stage kidney disease

  This project will test whether a specific TLR4 gene change (rs2149356) is linked to periodontitis in adults aged 30–60 who are on hemodialysis for end-stage kidney disease compared with otherwise healthy adults who also have periodontitis.

  Recruiting Ain Shams University · Al Fayyum, Faiyum Governorate · NCT06755372

• Registry for patients with kidney disease and heart issues

  This study collects information from adults with kidney disease and heart problems to see how their treatments and outcomes differ, helping us understand their health better.

  Recruiting Queen Mary University of London · London · NCT06521801

• External support implant for arteriovenous fistula in dialysis patients

  This study is testing if a new device called VasQ can help create better access points for dialysis in patients with kidney failure compared to standard methods.

  Recruiting at 11 sites Laminate Medical Technologies · Long Beach, California and 12 other locations · NCT06516653

• Assessing quality of life in children with posterior urethral valves

  This study looks at how being treated for posterior urethral valves affects the quality of life for boys aged 6 to 17, focusing on their kidney health and daily living.

  Recruiting Hospices Civils de Lyon · Bron, Bron · NCT06439862

• Observational study of HeRO Graft and Super HeRO in hemodialysis patients

  This study is testing how safe and effective the HeRO Graft System and Super HeRO Adaptor are for adults on hemodialysis who have run out of other options for dialysis access.

  Recruiting at 7 sites Merit Medical Systems, Inc. · Washington D.C., District of Columbia and 6 other locations · NCT06422871

• How blood flow and sounds relate in arteriovenous fistulas

  This study will test whether MRI and ultrasound recordings of blood flow and the sounds from an AVF can help predict fistula problems in adults with end-stage renal disease who need a new forearm access.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, Bergamo · NCT06411353

• Individualized sodium management versus standard treatment in hemodialysis

  This study will test whether personalized sodium control during hemodialysis helps people with end-stage kidney disease reduce weight gain between sessions and have fewer blood pressure or heart-related problems during dialysis.

  Recruiting Fresenius Medical Care Deutschland GmbH · Mariánské Lázně · NCT06341452

• Xeltis Hemodialysis Access conduit for patients with end-stage renal disease

  This study is testing a new device called the Xeltis Hemodialysis Access conduit to see if it can safely help adults with end-stage kidney disease get better access for their hemodialysis treatment.

  Recruiting at 2 sites Xeltis · Lisbon and 1 other locations · NCT06329310

• Microcirculation, Dialysis Modality, and Sequestered Salt in Dialysis Patients

  This study tests five dialysis approaches (different modes and dialysate sodium levels) to see how they affect tiny blood vessel function and hidden salt in adult dialysis patients.

  Recruiting at 2 sites Amsterdam UMC, location VUmc · Amstelveen, North Holland and 1 other locations · NCT06327750

• Improving quality of life for kidney transplant waitlist candidates

  This study is testing a new support program to help low-income people on the kidney transplant waitlist who are frail or at risk of frailty improve their physical function and overall well-being.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06326905

• Routine electronic symptom monitoring for adults on dialysis

  This project tests whether regular electronic symptom questionnaires for adults on dialysis can improve their quality of life.

  Recruiting at 2 sites Central Hospital, Nancy, France · Gradignan and 2 other locations · NCT06257134

• Using automated ultrasound to assess arteriovenous fistula maturation

  This study tests if using a special ultrasound system can help people with end-stage kidney disease get their dialysis access ready faster than the usual care.

  Recruiting at 21 sites Sonavex, Inc. · Dothan, Alabama and 22 other locations · NCT06190717

• Assessing the impact of a new dialysis method on patient symptoms

  This study is testing a new dialysis method to see if it can help people with end-stage kidney disease feel better by reducing their symptoms during treatment.

  Recruiting at 4 sites London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Winnipeg, Manitoba and 3 other locations · NCT06032208

• SelfWrap-Assisted Arteriovenous Fistulas for Chronic Kidney Disease

  This study is testing if a new wrap called SelfWrap can make it safer and more effective for people with chronic kidney disease to have a new arteriovenous fistula created.

  Recruiting at 28 sites VenoStent · Bullhead City, Arizona and 27 other locations · NCT06001827

• Comparing two beta blockers for heart health in dialysis patients

  This study is testing which beta blocker, metoprolol or carvedilol, is better for heart health in veterans on dialysis to see if it can help them live longer and feel better.

  Recruiting at 12 sites Phase 3 VA Office of Research and Development · Long Beach, California and 17 other locations · NCT05931276

• Endoscopic sleeve gastroplasty for obese kidney transplant candidates

  This study is testing if a procedure called endoscopic sleeve gastroplasty can help obese patients with kidney disease lose enough weight to qualify for a kidney transplant.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome · NCT05917795

• Registry for a new type of artery graft for dialysis access

  This study is testing a new type of artery graft to see if it can safely and effectively help adults with kidney failure get the dialysis access they need.

  Recruiting at 4 sites LifeNet Health · Mobile, Alabama and 3 other locations · NCT05880537

• Comparing automated peritoneal dialysis with remote management to standard peritoneal dialysis

  This study is testing whether automated peritoneal dialysis with remote management can improve the health and quality of life for people with end-stage kidney disease compared to standard peritoneal dialysis.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT05738525

• Telemonitoring platform for high-risk chronic kidney disease patients

  This study is testing if a new virtual care platform can help people with advanced kidney disease stay healthier and avoid trips to the emergency room or hospital.

  Recruiting at 5 sites University of Manitoba · Winnipeg, Manitoba and 4 other locations · NCT05726526

• Analysis of sounds from vascular access in dialysis patients

  This study is testing whether listening to the sounds from different types of vascular access can help doctors understand how well they work for patients on dialysis.

  Recruiting Mario Negri Institute for Pharmacological Research · Bergamo, BG · NCT05612022

• Using CoQ10 and exercise to improve muscle function in kidney disease patients

  This study is testing whether taking CoQ10 along with high-intensity exercise can help improve muscle strength and overall physical performance in patients with kidney disease who are on dialysis.

  Recruiting Phase 3 Vanderbilt University Medical Center · Sacramento, California and 1 other locations · NCT05422534

• Transplanting organs from HIV-positive donors to HIV-positive recipients

  This study is testing whether kidney transplants from HIV-positive donors to HIV-positive recipients are safe and effective for people living with HIV.

  Recruiting Tulane University · Metairie, Louisiana · NCT05159466

• Rheopheresis as an add-on treatment for calciphylaxis in people on hemodialysis

  This trial will try adding rheopheresis to usual care to see if it helps people on hemodialysis with ulcerated or necrotic calciphylaxis skin lesions heal and improve symptoms.

  Recruiting at 16 sites University Hospital, Lille · Angers and 28 other locations · NCT04654000

• Using the BD® WavelinQ™ EndoAVF System to create arteriovenous fistulas for dialysis patients

  This study is testing a new device to see if it can safely create access points for dialysis in patients with severe kidney disease.

  Recruiting at 15 sites C. R. Bard · La Jolla, California and 16 other locations · NCT04634916

• Evaluating DCR-PHXC for patients with Primary Hyperoxaluria Type 1 and severe kidney disease

  This study is testing a new treatment called DCR-PHXC to see if it can help people with Primary Hyperoxaluria Type 1 and severe kidney disease feel better.

  Recruiting at 6 sites Phase 2 Novo Nordisk A/S · San Francisco, California and 17 other locations · NCT04580420

• Using intravascular ultrasound to improve dialysis access for patients with end-stage renal disease

  This study is testing if using a special ultrasound can help doctors find problems with blood vessels in patients on dialysis to improve their treatment.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT04399941

• Using stem cells to improve blood vessel access for dialysis patients

  This study is testing whether using stem cells can help improve blood vessel access for people with kidney failure who need dialysis.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT04392206

• Comparing a new peritoneal dialysis solution to standard glucose solutions for kidney disease patients

  This study is testing a new low glucose dialysis solution called XyloCore to see if it works better than standard glucose solutions for patients with End-Stage Renal Disease on peritoneal dialysis.

  Recruiting at 33 sites Phase 3 Iperboreal Pharma Srl · Aalborg and 40 other locations · NCT03994471

• Registry for patients with end-stage renal disease in Lorraine

  This study is collecting information from patients with end-stage kidney disease in Lorraine to help improve their treatment and care.

  Recruiting Central Hospital, Nancy, France · Nancy · NCT03967808

• Evaluating Warfarin for Stroke Prevention in Dialysis Patients with Atrial Fibrillation

  This study is testing if starting Warfarin can safely help dialysis patients with atrial fibrillation reduce their risk of stroke.

  Recruiting at 13 sites Phase 4 Copenhagen University Hospital, Rigshospitalet · Herlev, Herlev and 12 other locations · NCT03862859

• Using social media to find live organ donors for patients in need

  This study is testing if using social media to share stories can help patients waiting for organ transplants find live donors more easily.

  Recruiting Johns Hopkins University · San Diego, California and 5 other locations · NCT03803423

• Comparing Envarsus XR® and Tacrolimus for Kidney Transplant Patients

  This study is testing whether a new kidney medication called Envarsus XR® is safer and more effective than the standard medication tacrolimus for people getting a kidney transplant.

  Recruiting Phase 2/3 University of Kentucky · Lexington, Kentucky · NCT03321656

• Biobank for calciphylaxis research

  This study is collecting patient samples to learn more about calciphylaxis, a rare condition that causes painful skin sores, in hopes of finding better treatments.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT03032835

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How life circumstances affect brain aging in people with end-stage kidney disease

  This project looks at how neighborhood, income, education, and personal resilience relate to earlier memory and thinking problems in adults with end-stage kidney disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11472074

• How life circumstances affect memory and thinking in people with end-stage kidney disease

  Researchers will look at how social and economic factors relate to memory and thinking problems across adults with end-stage kidney disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11326343

• How long the shingles (zoster) vaccine protects people with kidney failure, before and after transplant

  This project checks how long the shingles vaccine protects adults with end-stage kidney disease who are waiting for or have received a kidney transplant.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11285305

• Activating a cell protein to prevent early dialysis fistula failure

  This research tests a drug-like activator of the Mac-1 protein to reduce inflammation and help new dialysis fistulas work better for people with end-stage kidney disease.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11262322

• Pain care for veterans with end-stage kidney disease

  This project looks at how changes in VA opioid policies have affected pain control and safety for veterans with end-stage kidney disease.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11240257

• How systemic racism affects cognitive aging in patients with end-stage renal disease

  This study is looking at how racism affects brain health in Black patients with severe kidney disease, aiming to understand why some people experience faster cognitive decline and how others manage to stay resilient, so we can find better ways to support their health.

  NIH research New York University School of Medicine · New York, United States · NIH-11080355

• Using integrin activation to improve the success of dialysis access in kidney disease patients

  This study is looking at a new way to help improve the success of arteriovenous fistulas for people on hemodialysis, by using a special treatment that may reduce inflammation and prevent problems that can cause these important connections to fail.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11019793

• Understanding immune responses to a shingles vaccine in patients with kidney disease

  This study is looking at how well the shingles vaccine works for people with severe kidney disease or those who have had a kidney transplant, to see if extra doses can help boost their protection against infections.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11014039

• Improving pain management for veterans with severe kidney disease

  This study looks at how new rules about prescribing opioids impact veterans with severe kidney disease who are dealing with pain, and it aims to find safer ways to help them manage their pain without increasing risks.

  NIH research VA Boston Health Care System · Boston, United States · NIH-10923830

• How nutrition and inflammation affect insulin resistance in patients with severe kidney disease

  This study is looking at how what you eat, inflammation, and insulin levels affect your health if you're on dialysis for kidney disease, with the goal of finding ways to help improve your nutrition and overall well-being.

  NIH research Veterans Health Administration · Nashville, United States · NIH-10908988

• Investigating treatment outcomes for patients with critical limb ischemia and end-stage renal disease

  This study is looking at the best treatment options for people with critical limb ischemia who also have severe kidney disease, to help doctors and patients make better choices about care and improve health outcomes.

  NIH research University of Florida · Gainesville, United States · NIH-10897869

• Helping older patients with kidney disease make better medical decisions

  This study is all about helping older patients with kidney disease share their treatment choices, like CPR and dialysis, in a clear and friendly way using a helpful video tool, so they can feel more confident about their medical decisions and communicate better with their doctors.

  NIH research Tufts Medical Center · Boston, United States · NIH-10890188

• Understanding and treating pulmonary hypertension in patients with severe kidney disease

  This study is looking into why some people with severe kidney disease develop high blood pressure in their lungs and is testing new treatments to help improve their health and well-being.

  NIH research Duke University · Durham, United States · NIH-10885975

• Expanding Medicare Advantage for patients with end-stage renal disease

  This study looks at how letting people with end-stage kidney disease join Medicare Advantage plans can help them get better healthcare and improve their health, especially for those in underserved communities.

  NIH research Brown University · Providence, United States · NIH-10795031

• Improving care and reducing costs for patients with end-stage renal disease on dialysis

  This study is looking at how having primary care doctors work more closely with patients on dialysis for kidney failure can lead to better health and lower healthcare costs, helping to find the best ways to support these patients.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10767240

Related topics

Quick answers

How many End Stage Renal Disease clinical trials are recruiting right now?

41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (19 trials), Italy (5 trials), France (5 trials), United Kingdom (3 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 1: 3, Phase 1/2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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